Craig Kaplan
@triggerloop.bsky.social
3.5K followers 710 following 5.2K posts
Professor, Department of Biological Sciences, University of Pittsburgh. RNA polymerase II mechanism, classic films, #classiccountdown once in awhile
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triggerloop.bsky.social
I think the only way I would have laughed harder is if you said the Horta. No- not even then!!!
triggerloop.bsky.social
OH MY GOD YOU CRAZY FOR THIS ONE FOUNDIE
Reposted by Craig Kaplan
gavinyamey.bsky.social
Wait, WHAT? The IRB gone. The IRB!

What an extraordinarily dangerous, harmful, unethical bunch of MAGA and MAHA lackeys we now have running US public health, healthcare, and health research; they have totally lost their moral compass (assuming they once had one?).
melodyschreiber.com
The entire HR department at the CDC is gone. Everyone at the IRB, which makes sure studies are conducted ethically and rigorously, and the ethics office, which oversee conflicts of interest for CDC leaders and advisory committee members, were also let go.
www.theguardian.com/us-news/2025...
‘Instability and confusion’ as CDC slashes 1,300 jobs before reinstating half
Trump administration says 700 notices were sent in error, while top CDC officer says ‘they didn’t think through what they were doing’
www.theguardian.com
triggerloop.bsky.social
Yeah the onion and pickles are so good w brisket on the straight from the bag white bread
Reposted by Craig Kaplan
kateclancy.bsky.social
I am being asked to tell my department which pieces of lab equipment should be supported with backup power because they expect rolling blackouts and brownouts in 2026 due to increased energy demands from AI. In case you're wondering how my day is going.
Reposted by Craig Kaplan
theonion.com
Injured Player Gives Thumbs-Down While Being Carted Off Field
Injured Player Gives Thumbs-Down While Being Carted Off Field
triggerloop.bsky.social
Very cool!
mendell-lab.bsky.social
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
Reposted by Craig Kaplan
amandamull.bsky.social
For Businessweek’s November issue, I have a feature about the high-fee premium credit card war being waged by American Express and Chase for the hearts, minds, and swipes of America’s affluent supershoppers. Gift link: www.bloomberg.com/news/feature...
Inside the Credit Card Battle to Win America’s Richest Shoppers
The fierce fight between Amex and Chase is playing out over higher fees, extravagant events and every perk imaginable.
www.bloomberg.com
triggerloop.bsky.social
I hope you were very baroque in letting them know how you feel about that
Reposted by Craig Kaplan
cryoempapers.bsky.social
Assessing scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions pubmed.ncbi.nlm.nih.gov/41081541/ #cryoem
triggerloop.bsky.social
Percentiles will go up literally because prob more ties at the top. “Dynamic” calibration is even harder now with random discussion order imo
Reposted by Craig Kaplan
paris.nyc
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements

we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)

www.consumerreports.org/lead/protein...
Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports
CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.
www.consumerreports.org
triggerloop.bsky.social
I am wondering about them doubling up next round (have they ever done that?)
triggerloop.bsky.social
The link is in the notice but not formatted as a hyperlink and the description makes it seem it is more relevant to applicants. I hadn’t initially detected it because of the wording but missing an entire round of panels is going to be pretty bad I feel
triggerloop.bsky.social
It’s so fucking bad and they are killing research that maybe has a chance to move the needle on this
triggerloop.bsky.social
Not much information there, but this is what is indicated for reviewers/peer review grants.nih.gov/grants/guide...
Most of the above text with some elisions
Initial Peer Review Meetings:  For the duration of the funding lapse, the NIH will not be able to conduct initial peer review meetings – whether in-person or through teleconferences or other electronic media. Also, during this time, the NIH staff will not be able to send or receive email messages or update website information. When operations resume, those meetings will be re-scheduled, and the pending applications will be processed and reviewed as soon as possible. 

Also, the results, including final impact scores and summary statements, of some peer review meetings that took place prior to the orderly shutdown of operations may not be available until operations resume.  Therefore, applicants with applications going through the peer review process should stay tuned to the national news to determine when operations of the government resume and then check the NIH website for information on any review meetings that may have been extended or re-scheduled.  The results of meetings held prior to a potential funding lapse will be released as soon as possible after resumption of operations.

Individuals who had agreed to serve on NIH review panels ("study sections") that were scheduled to meet during the funding lapse will have access to the Internet Assisted Review (IAR) site and will be able to upload initial critiques and initial scores, but technical support will not be available. .....  Therefore, peer reviewers should stay tuned to the national news to determine when operations of the NIH will resume and then check the NIH website for information on meetings that have been re-scheduled.   As soon as possible after operations resume, the NIH Scientific Review Officer in charge of the review meeting will contact those reviewers with more detailed information.
triggerloop.bsky.social
There once was a man from Nantucket
He had to review grants but said suck it
He turned to AI
A thumb in my eye
I wish this poem were your obit
triggerloop.bsky.social
I had this or maybe different color trim!!!