Bede Portz
@ysptsps.bsky.social
Biotech. Interests: oncology, transcription, RNA, small molecule drug discovery, RNA therapeutics, protein aggregation, phase transitions
Reposted by Bede Portz
Been saying this for weeks, but this season is an exact copy of 2 years ago for the Eagles. A bad team with an awful OC masquerading as a good team for half the season until it all falls apart. They might win 2 games the rest of the year.
November 28, 2025 at 10:35 PM
Been saying this for weeks, but this season is an exact copy of 2 years ago for the Eagles. A bad team with an awful OC masquerading as a good team for half the season until it all falls apart. They might win 2 games the rest of the year.
Reposted by Bede Portz
New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TDP-43 controls RNA structure through high affinity lattice interactions
TDP-43 is an RNA binding protein implicated in neurodegenerative disease. TDP-43 binds to GU dinucleotide repeats, which are highly abundant sequences in human RNA. Here we show TDP- 43 has one of the...
www.biorxiv.org
November 29, 2025 at 12:14 AM
New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bede Portz
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
AA but for ice cream near me
November 23, 2025 at 2:36 AM
AA but for ice cream near me
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants www.nytimes.com/2025/11/16/u...
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants
www.nytimes.com
November 17, 2025 at 12:37 PM
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants www.nytimes.com/2025/11/16/u...
Dominos has stepped its game up.
November 16, 2025 at 4:10 AM
Dominos has stepped its game up.
Dominos has stepped its game up.
November 16, 2025 at 4:10 AM
Dominos has stepped its game up.
www.biorxiv.org/content/10.1... @rohitpappu68.bsky.social and Jim Shorter latest banger just dropped
Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.
RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...
www.biorxiv.org
November 16, 2025 at 2:11 AM
www.biorxiv.org/content/10.1... @rohitpappu68.bsky.social and Jim Shorter latest banger just dropped
Reposted by Bede Portz
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by Bede Portz
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
November 14, 2025 at 1:20 PM
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
I wish adults could wear overalls.
November 13, 2025 at 2:05 AM
I wish adults could wear overalls.
Reposted by Bede Portz
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 8, 2025 at 9:58 PM
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Reposted by Bede Portz
The password to the Louvre’s video surveillance system was “Louvre,” according to a museum employee
Password to Louvre’s video surveillance system was 'Louvre', according to employee
According to an employee with knowledge of the system, the password to the Louvre's video surveillance system was simply "Louvre" at the time of the robbery last month.
abcnews.go.com
November 6, 2025 at 11:21 PM
The password to the Louvre’s video surveillance system was “Louvre,” according to a museum employee
Smoltz is a terrible announcer
November 2, 2025 at 3:52 AM
Smoltz is a terrible announcer
They dont give kids 100 grands or payday anymore we used to be a real country @triggerloop.bsky.social
November 1, 2025 at 1:21 AM
They dont give kids 100 grands or payday anymore we used to be a real country @triggerloop.bsky.social
Reposted by Bede Portz
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Abstract B105: Oral small molecule MYC condensate modulators (c-mods) induce robust anti-tumor responses in preclinical solid tumor models aacrjournals.org/mct/article/24… From my Dewpoint era. I lead this program from ideation to late lead optimization. I hope it advances to the clinic.
https://aacrjournals.org/mct/article/24…
October 23, 2025 at 2:41 AM
Abstract B105: Oral small molecule MYC condensate modulators (c-mods) induce robust anti-tumor responses in preclinical solid tumor models aacrjournals.org/mct/article/24… From my Dewpoint era. I lead this program from ideation to late lead optimization. I hope it advances to the clinic.
Reposted by Bede Portz
the Muppets have been real quiet since the Louvre heist
October 19, 2025 at 10:19 PM
the Muppets have been real quiet since the Louvre heist
From @retof.bsky.social @kevin-dean.bsky.social et al. As a big proponent of image-based high throughput phenotypic screening and AI-enabled hit calling this looks really cool www.biorxiv.org/content/10.1...
Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy
Light-Sheet Fluorescence Microscopy (LSFM) enables gentle, rapid, and efficient volumetric imaging of biological specimens. Despite its potential, LSFM has fragmented into multiple variants, each narr...
www.biorxiv.org
October 13, 2025 at 1:10 PM
From @retof.bsky.social @kevin-dean.bsky.social et al. As a big proponent of image-based high throughput phenotypic screening and AI-enabled hit calling this looks really cool www.biorxiv.org/content/10.1...
Reposted by Bede Portz
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
October 8, 2025 at 8:26 PM
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
Reposted by Bede Portz
A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.
October 7, 2025 at 5:55 PM
A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.