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David Kuster @rnadavid.bsky.social · 5d

'This is scientifically incredibly fascinating to have an entire field that's built on a technical limitation.':D

David Kuster @rnadavid.bsky.social · 5d

Very insightful reconsideration what Stress Granules might actually be good for!

Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.

Amazing talk & scholarship by @drummondlab.bsky.social!

youtu.be/caAPToh8v0Q

Physical Properties of the Cytoplasm Seminar Series #25 | Allan Drummond

YouTube video by Physical Properties of the Cytoplasm

youtu.be

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Reposted by David Kuster

André Nadler @nadlerlab.bsky.social · 5d

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

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Reposted by David Kuster

David W. Sanders! @davidwsanders.bsky.social · 6d

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

UT Southwestern researcher receives NIH Director’s New Innovator Award

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

www.utsouthwestern.edu

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Reposted by David Kuster

Jerelle Joseph @jerelleaj.bsky.social · 6d

Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...

Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability

Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...

www.biorxiv.org

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Reposted by David Kuster

Ryan Flynn @raflynn5.bsky.social · 7d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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Reposted by David Kuster

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 9d

Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1

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Reposted by David Kuster

Isaac Wong @isaacsiuwong.bsky.social · 9d

Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶‍♂️'s CDK5RAP2.

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 9d

Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1

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David Kuster @rnadavid.bsky.social · 10d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Reposted by David Kuster

Camille Moore @camille-moore.bsky.social · 12d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

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Reposted by David Kuster

Jerelle Joseph @jerelleaj.bsky.social · 21d

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...

pubs.rsc.org

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Reposted by David Kuster

brangwynnelab.bsky.social @brangwynnelab.bsky.social · 24d

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

www.princeton.edu

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Reposted by David Kuster

Frog and Toad Bot @frogandtoadbot.bsky.social · 22d

Frog drank the tea, and then he said, “Tell me a story while I am resting.”

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Reposted by David Kuster

RCSB Protein Data Bank @rcsbpdb.bsky.social · 25d

September 21 is #WorldAlzheimersDay
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

PDB101: Molecule of the Month: Amyloids

Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

pdb101.rcsb.org

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Reposted by David Kuster

Jack Bateman @jbateman01.bsky.social · 25d

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging

Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...

www.science.org

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Reposted by David Kuster

Amy Strom @dnamystrom.bsky.social · Sep 13

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!

www.molbiolcell.org/doi/full/10....

Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social

And huge thank you @ascbiology.bsky.social

Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell

Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...

www.molbiolcell.org

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Reposted by David Kuster

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 26d

Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.

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Reposted by David Kuster

Barack Obama @barackobama.bsky.social · 26d

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

Let’s be clear about what happened to Jimmy Kimmel

Trump’s most brazen attack on free speech yet.

www.yahoo.com

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Reposted by David Kuster

Guillermina Ramirez-SanJuan @guille-rochelle.bsky.social · 26d

In another exciting development our new preprint is online:
www.biorxiv.org/cgi/content/...

This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

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Reposted by David Kuster

Sarah Cohen @cohenlaboratory.bsky.social · 27d

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

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Reposted by David Kuster

Lars Hubatsch @larshubatsch.bsky.social · 28d

Paper alert!🧪
We derive a theory that underpins interface resistance with a physical foundation and look at how it changes droplet growth and recovery kinetics! Awesome collab with @bosste.bsky.social Tyler Harmon @hymanlab.bsky.social @m-pol.bsky.social and Frank Jülicher @mpipks.bsky.social 1/4

Transport kinetics across interfaces between coexisting liquid phases

elifesciences.org

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David Kuster @rnadavid.bsky.social · 28d

That's probably at the heart of why the world shifts towards populism & ultimately facism..

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Reposted by David Kuster

Jerelle Joseph @jerelleaj.bsky.social · 29d

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by David Kuster

Diez Lab @ TU Dresden @stefandiezlab.bsky.social · Sep 14

What a pleasure to collaborate with Laura #Schaedel and her team at @uni-saarland.de to study #microtubule damage and repair under mechanical load.

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Reposted by David Kuster

Anaïs Bailles @anaisbailles.bsky.social · Sep 12

Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.

Elise Cutts @elisecutts.bsky.social · Sep 11

Hydra are ~basically~ immortal.

Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!

This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️

Hydra are a cosmos in a cuvette

Anaïs Bailles on astrophysics and immortal animals

www.reviewertoo.com

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