David Kuster
@rnadavid.bsky.social
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. IDPs, biomolecular condensates and RNA fun @HymanLab. And birds.
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
Reposted by David Kuster
Many thanks to @fpmaragall.bsky.social for this great opportunity! Together with Natalia Rodríguez Muela’s group at @dzne.science in Dresden, we’ll explore triggers and inhibitors of the earliest steps in Alzheimer’s disease progression.
bsky.app/profile/fpma...
bsky.app/profile/fpma...
🧠 Ya tenemos los proyectos ganadores del #PMRP 2024, nuestro programa de becas para impulsar la investigación clínica y traslacional en #Alzheimer. 💚
👇
👇
October 9, 2025 at 11:20 AM
Many thanks to @fpmaragall.bsky.social for this great opportunity! Together with Natalia Rodríguez Muela’s group at @dzne.science in Dresden, we’ll explore triggers and inhibitors of the earliest steps in Alzheimer’s disease progression.
bsky.app/profile/fpma...
bsky.app/profile/fpma...
Reposted by David Kuster
Truly honored to receive the STS Science Award as recognition from the Signal Transduction Society! I am grateful for the support of my mentor Tony Hyman @hymanlab.bsky.social, institutional support @mpi-cbg.de, and funding by the @dfg.de and the NOMIS Foundation.
November 27, 2025 at 4:53 PM
Truly honored to receive the STS Science Award as recognition from the Signal Transduction Society! I am grateful for the support of my mentor Tony Hyman @hymanlab.bsky.social, institutional support @mpi-cbg.de, and funding by the @dfg.de and the NOMIS Foundation.
Reposted by David Kuster
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
November 28, 2025 at 7:00 PM
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
Reposted by David Kuster
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
November 28, 2025 at 3:12 PM
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
Reposted by David Kuster
It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
November 28, 2025 at 7:56 PM
It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.
Reposted by David Kuster
Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
Protein plasticity and evolution: The research group of Agnes Toth-Petroczy at MPI-CBG
YouTube video by MPI-CBG
youtu.be
November 28, 2025 at 12:48 PM
Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
Reposted by David Kuster
𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐧 𝐫𝐞𝐜𝐞𝐢𝐯𝐢𝐧𝐠 𝐭𝐡𝐞 𝐒𝐓𝐒 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐀𝐰𝐚𝐫𝐝 2025! 🎉
At the 28th STS Meeting in Weimar Theresia Gutmann @thegutmann.bsky.social was honored with this award, which recognizes outstanding research by postdocs or junior PIs within the STS. Congratulations! @mpi-cbg.de #STS #CellCommSummit
At the 28th STS Meeting in Weimar Theresia Gutmann @thegutmann.bsky.social was honored with this award, which recognizes outstanding research by postdocs or junior PIs within the STS. Congratulations! @mpi-cbg.de #STS #CellCommSummit
November 27, 2025 at 10:06 AM
𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐧 𝐫𝐞𝐜𝐞𝐢𝐯𝐢𝐧𝐠 𝐭𝐡𝐞 𝐒𝐓𝐒 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐀𝐰𝐚𝐫𝐝 2025! 🎉
At the 28th STS Meeting in Weimar Theresia Gutmann @thegutmann.bsky.social was honored with this award, which recognizes outstanding research by postdocs or junior PIs within the STS. Congratulations! @mpi-cbg.de #STS #CellCommSummit
At the 28th STS Meeting in Weimar Theresia Gutmann @thegutmann.bsky.social was honored with this award, which recognizes outstanding research by postdocs or junior PIs within the STS. Congratulations! @mpi-cbg.de #STS #CellCommSummit
Reposted by David Kuster
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
November 27, 2025 at 1:17 PM
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
Reposted by David Kuster
See how far a PhD from @cellbiol-mrclmb.bsky.social can take you! Still a few days left to apply for a PhD place here to start in October 2026: www2.mrc-lmb.cam.ac.uk/students/int...
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 2:24 PM
See how far a PhD from @cellbiol-mrclmb.bsky.social can take you! Still a few days left to apply for a PhD place here to start in October 2026: www2.mrc-lmb.cam.ac.uk/students/int...
Reposted by David Kuster
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
Reposted by David Kuster
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
bit.ly
November 27, 2025 at 9:31 AM
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
Reposted by David Kuster
🔔Join us next Wednesday for #FragileNucleosome! 2 fantastic talks on chromatin regulation:🔬 @mariamafau.bsky.social on ZIC2's dual role in neural induction 🔬 @jhenninger.bsky.social on how RNA-binding proteins drive transcription
📋Register here for the entire series: us06web.zoom.us/webinar/regi...
📋Register here for the entire series: us06web.zoom.us/webinar/regi...
November 26, 2025 at 10:16 AM
🔔Join us next Wednesday for #FragileNucleosome! 2 fantastic talks on chromatin regulation:🔬 @mariamafau.bsky.social on ZIC2's dual role in neural induction 🔬 @jhenninger.bsky.social on how RNA-binding proteins drive transcription
📋Register here for the entire series: us06web.zoom.us/webinar/regi...
📋Register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by David Kuster
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs - new from @drummondlab.bsky.social www.cell.com/molecular-ce...
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs
Glauninger, Bard, Wong Hickernell, et al. reveal that stress causes transcriptome-wide
mRNP condensation, largely independent of length and often without stress granule
formation, but newly synthesize...
www.cell.com
November 25, 2025 at 3:32 PM
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs - new from @drummondlab.bsky.social www.cell.com/molecular-ce...
Reposted by David Kuster
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Kuster
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by David Kuster
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by David Kuster
Universität Heidelberg mit drei Förderanträgen für Sonderforschungsbereiche erfolgreich – Für die Verlängerung von zwei transregionalen ... www.uni-heidelberg.de/de/newsroom/...
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
November 21, 2025 at 10:56 AM
Universität Heidelberg mit drei Förderanträgen für Sonderforschungsbereiche erfolgreich – Für die Verlängerung von zwei transregionalen ... www.uni-heidelberg.de/de/newsroom/...
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
Reposted by David Kuster
Complex life of RNA is now open for registration (though deadline is Sept 1 so take your time...)
this is a very good meeting.
www.embl.org/about/info/c...
this is a very good meeting.
www.embl.org/about/info/c...
The complex life of RNA
www.embl.org
November 20, 2025 at 1:07 PM
Complex life of RNA is now open for registration (though deadline is Sept 1 so take your time...)
this is a very good meeting.
www.embl.org/about/info/c...
this is a very good meeting.
www.embl.org/about/info/c...
Reposted by David Kuster
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 20, 2025 at 7:46 AM
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Reposted by David Kuster
Published in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 20, 2025 at 2:24 AM
Published in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by David Kuster
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by David Kuster
Happy #WorldAnteaterDay! This Giant Anteater (Myrmecophaga tridactyla) #SciArt is by Édouard Traviès for Charles Dessalines d'Orbigny, Dictionnaire d'Histoire Naturelle (1849). Contributed to BHL by @ncsulibraries.bsky.social: www.biodiversitylibrary.org/page/19538021 🧪 📖 🌎 🐜 #ILoveBHL
November 19, 2025 at 4:27 PM
Happy #WorldAnteaterDay! This Giant Anteater (Myrmecophaga tridactyla) #SciArt is by Édouard Traviès for Charles Dessalines d'Orbigny, Dictionnaire d'Histoire Naturelle (1849). Contributed to BHL by @ncsulibraries.bsky.social: www.biodiversitylibrary.org/page/19538021 🧪 📖 🌎 🐜 #ILoveBHL
Reposted by David Kuster
🙌 Hello from #EESNucleus.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
November 19, 2025 at 1:46 PM
🙌 Hello from #EESNucleus.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
Reposted by David Kuster
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!
November 19, 2025 at 10:17 AM
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!