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RCSB Protein Data Bank @rcsbpdb.bsky.social · 10h

Designed to attain its binding shape prior to binding, the antibiotic can serve as a powerful model for future antibiotics.

Novel antibiotic overcomes drug-resistant bacteria

Antibiotics fight bacteria in different ways. Some kill bacteria by destroying their cell walls. Others bind to bacteria’s ribosomes, halting their ability to produce proteins. Over time, bacteria …

lightsources.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 1d

How visual rhodopsin responds to light in one of nature’s fastest reactions.

Unveiling the Molecular Mechanism of Vision Using Ultrafast X-ray Pulses | Department of Energy

How visual rhodopsin responds to light in one of nature’s fastest reactions. 

www.energy.gov

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 2d

Visit PDB-101 for more about Nobel Prize-winning Computed Structure Models and their measures of reliability; limitations; and how they can help determine experimental structures

PDB101: Learn: Exploring Structural Biology with Computed Structure Models (CSMs)

Computational methods like AlphaFold2 and RoseTTAFold2 use structures in the PDB archive to predict the folding of proteins.

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 3d

October 9 is #WorldSightDay
Watch how Vitamin A activates the molecular pathways essential for vision in this new PDB-101 video

PDB101: Video: Vitamin A and Vision

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

RCSB Protein Data Bank @rcsbpdb.bsky.social · 4d

The genome of HIV is packaged inside a distinctive cone-shaped capsid, which protects the RNA and delivers it to the cells that HIV infects.
Build a paper model of the HIV capsid by downloading and printing this template PDF.

PDB101: Learn: Paper Models: HIV Capsid

At the center of HIV, an unusual cone-shaped capsid protects the viral genome and delivers it into infected cells

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 5d

The genome of ebola virus contains instructions for building seven proteins, which assemble with the genomic RNA to form one of the deadliest viruses.

PDB101: Molecule of the Month: Ebola Virus Proteins

Structures of ebola virus proteins are giving new hope for fighting this deadly virus

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 6d

The bloodstream is filled with molecules and cells that search for invaders and destroy them if they are found. PDB structures have revealed how the immune system recognizes viruses and bacteria while leaving our normal molecules alone.
More at PDB-101:

PDB101: Browse: Immune System

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 7d

Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist

After bizarre journey, prized history of molecular biology archive finds new home

Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist

www.science.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 8d

These findings could open the door to new drugs that target host proteins rather than the virus. This strategy may lead to new treatments effective against SARS-CoV-2 and other coronaviruses, even as the pathogens continue to evolve.

Host Proteins Identified in SARS-CoV-2 Replication Pathways Reveal Drug Targets

New research reveals promising drug targets to block coronaviruses at multiple stages of infection—even across different strains.

www.genengnews.com

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 9d

Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive.
Who will win next week?

PDB101: Browse: Nobel Prizes and PDB structures

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 10d

Register Now for Webinar: Exploring the Workhorses of Biotechnology
On November 6, learn how to use RCSB PDB to analyze plastic-degrading enzymes

PDB101: Register Now for Webinar: Exploring the Workhorses of Biotechnology

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 11d

Within minutes of starting to eat, cells in your gut rev into action and start secreting two peptide hormones--glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones are known as incretins.
More at PDB-101:

PDB101: Molecule of the Month: Incretins

GLP-1 and GIP are hormones that are released soon after you eat a meal

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 12d

Explore PDB-themed #Inktober #SciArt images from structural biologist Irina Bezsonova from (2023 and 2022)

PDB101: Irina Bezsonova Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 13d

Watch the Pairwise Alignment Tool Office Hour and learn how to align one or more protein chains to a reference structure in a pairwise manner

Introduction to RCSB PDB’s Pairwise Alignment Tool

The Pairwise Structure Alignment Tool (https://www.rcsb.org/alignment) can align one or more protein chains to a reference structure in a pairwise manner. This tool allows for simultaneous analysis and visualization of three-dimensional (3D) structure alignments and structure-based one-dimensional (

www.youtube.com

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 14d

An siRNA screen performed by scientists at Scripps Research has pinpointed dozens of human proteins that SARS-CoV-2 uses to complete its replication cycle. These findings could open the door to new drugs that target host proteins rather than the virus.

Host Proteins Identified in SARS-CoV-2 Replication Pathways Reveal Drug Targets

New research reveals promising drug targets to block coronaviruses at multiple stages of infection—even across different strains.

www.genengnews.com

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 15d

In a new study, experts discovered that older people produce a glycosylated protein called apoplipoprotein D (ApoD), which is involved in lipid metabolism and inflammation, at much higher levels than in younger people

News - Scientists discover why the flu is more deadly for older people - University of Nottingham

Scientists have discovered why older people are more likely to suffer severely from the flu, and can now use their findings to address this risk.

www.nottingham.ac.uk

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 16d

wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports

Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report

Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric

www.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 17d

September 25th is International #Ataxia Awareness Day
PDB structures help us better understand the disease and treament options

Ataxia: A symptom and a disease

It's International Ataxia Awareness Day.

www.asbmb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 18d

MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension

MolViewSpec: a Mol* extension for describing and sharing molecular visualizations

Abstract. Data visualization is a pivotal component of a structural biologist’s arsenal. The Mol* Viewer makes molecular visualizations available to broade

academic.oup.com

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 19d

Register for the Sept 25 Virtual Office Hour on PDB Policies
Learn about PDB policies about deposition and biocuration.

Register for the Sept 25 Virtual Office Hour on PDB Policies

Learn about PDB policies about deposition and biocuration.

www.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 20d

Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme

PDB101: Learn: Flyers, Posters, & Calendars: Posters: Folding of Protein Domains

This poster highlights common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme.

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 21d

Amyloid-beta precursor protein (APP) is a complicated protein with many functions. A corrupted form can destroy nerve cells, leading to the loss of thought and memory in Alzheimer's disease.
#WorldAlzheimersDay

PDB101: Molecule of the Month: Amyloid-beta Precursor Protein

Cell-clogging amyloids form when proteins improperly aggregate

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 22d

September 21 is #NationalOpioidAwarenessDay
Morphine and other opioid drugs bind to receptors in the nervous system, controlling pain

PDB101: Molecule of the Month: Opioid Receptors

Morphine and other opioid drugs bind to receptors in the nervous system, controlling pain

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 23d

September 21 is #WorldAlzheimersDay
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

PDB101: Molecule of the Month: Amyloids

Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

pdb101.rcsb.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · 24d

Register Now for Webinar: Exploring Integrative Structures with RCSB PDB
On November 12, learn how to explore PDB structures determined using integrative and hybrid methods with RCSB PDB tools

PDB101: Register Now for Webinar: Exploring Integrative Structures with RCSB.org

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org