André Nadler
@nadlerlab.bsky.social
Chemist in a CellBio place. Fan of lipids & membranes
Pinned
André Nadler
@nadlerlab.bsky.social
· Aug 21
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by André Nadler
Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
Protein plasticity and evolution: The research group of Agnes Toth-Petroczy at MPI-CBG
YouTube video by MPI-CBG
youtu.be
November 28, 2025 at 12:48 PM
Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
Reposted by André Nadler
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
That is a beautiful piece of work! Congratulations!
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
www.nature.com
November 26, 2025 at 6:21 PM
That is a beautiful piece of work! Congratulations!
Reposted by André Nadler
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
www.nature.com
November 26, 2025 at 4:33 PM
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Reposted by André Nadler
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Reposted by André Nadler
PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social
www.polimi.it/dottorato/fu...
www.polimi.it/dottorato/fu...
November 24, 2025 at 11:05 AM
PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social
www.polimi.it/dottorato/fu...
www.polimi.it/dottorato/fu...
Reposted by André Nadler
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by André Nadler
I am honored and excited to present our recent work on mixed AND asymmetric membranes at @bppbseminar.bsky.social! 🧪
My online talk will be this Friday, 11/21/25, 11am US Eastern time.
Many thanks to the organizers for putting this together! More details here: sites.google.com/view/bppb-se...
My online talk will be this Friday, 11/21/25, 11am US Eastern time.
Many thanks to the organizers for putting this together! More details here: sites.google.com/view/bppb-se...
November 19, 2025 at 8:16 PM
I am honored and excited to present our recent work on mixed AND asymmetric membranes at @bppbseminar.bsky.social! 🧪
My online talk will be this Friday, 11/21/25, 11am US Eastern time.
Many thanks to the organizers for putting this together! More details here: sites.google.com/view/bppb-se...
My online talk will be this Friday, 11/21/25, 11am US Eastern time.
Many thanks to the organizers for putting this together! More details here: sites.google.com/view/bppb-se...
Reposted by André Nadler
✨ A study in nature.com from our Faculty at @unikarlova.cuni.cz reveals Solarion arienae, a rare #protist forming a newly identified eukaryotic supersroup Disparia. A unique window into early #eukaryotic cell #evolution. 🌍🔬👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 19, 2025 at 4:03 PM
✨ A study in nature.com from our Faculty at @unikarlova.cuni.cz reveals Solarion arienae, a rare #protist forming a newly identified eukaryotic supersroup Disparia. A unique window into early #eukaryotic cell #evolution. 🌍🔬👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 18, 2025 at 6:20 AM
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Reposted by André Nadler
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by André Nadler
Research team @nadlerlab.bsky.social @hzdr.bsky.social & EPFL with first author Kristin Böhlig develops probes to vizualize transport of ether lipids in the cell. Publication in @angewandtechemie.bsky.social www.mpi-cbg.de/news-outreac...
New toolkit to study ether lipids
Research team develops probes to vizualize transport of ether lipids in the cell.
www.mpi-cbg.de
November 14, 2025 at 2:31 PM
Research team @nadlerlab.bsky.social @hzdr.bsky.social & EPFL with first author Kristin Böhlig develops probes to vizualize transport of ether lipids in the cell. Publication in @angewandtechemie.bsky.social www.mpi-cbg.de/news-outreac...
Beautiful work as per usual - Congratulations!!!
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...
rdcu.be
November 12, 2025 at 7:44 PM
Beautiful work as per usual - Congratulations!!!
Reposted by André Nadler
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
November 12, 2025 at 6:57 PM
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
Reposted by André Nadler
ooof this feels like most every university rn
November 12, 2025 at 3:28 AM
ooof this feels like most every university rn
Reposted by André Nadler
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
erc.europa.eu
November 11, 2025 at 1:22 PM
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Reposted by André Nadler
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by André Nadler
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by André Nadler
It’s true that some scientific results can’t be replicated. And it’s also true that some people do the right thing when that happens:
Taking It Back, The Right Way
www.science.org
November 4, 2025 at 7:50 PM
It’s true that some scientific results can’t be replicated. And it’s also true that some people do the right thing when that happens:
Reposted by André Nadler
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by André Nadler
Congratulations! In the current call of the European Research Council, Max Planck researchers have secured five Synergy Grants. Together with the University of Cambridge, we are among the top three most successful #research institutions in #Europe ! 🙌 www.mpg.de/25684336/erc... @erc.europa.eu
Strong as a team
Five Max Planck researchers secure prestigious ERC Synergy Grants in 2025, enhancing collaborative research in Europe.
www.mpg.de
November 6, 2025 at 1:28 PM
Congratulations! In the current call of the European Research Council, Max Planck researchers have secured five Synergy Grants. Together with the University of Cambridge, we are among the top three most successful #research institutions in #Europe ! 🙌 www.mpg.de/25684336/erc... @erc.europa.eu
Reposted by André Nadler
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.
Check it out.
November 6, 2025 at 1:09 PM
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.
Check it out.
Reposted by André Nadler
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Reposted by André Nadler
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by André Nadler
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD