Abdou Rachid Thiam
@abdourachidthiam.bsky.social
@CNRS Research Director @ENS_ULM. Interested in Droplets, Metabolism, Organelles, Lipids, BioPhysics, Microfluidics & Co, πΈπ³
DDHD2, tied to hereditary spastic paraplegia, acts as both a triglyceride lipase and transacylase. While #lipiddroplets don't accumulate in neurons, this raises key questions about fatty acid composition and LD dynamics in these cells. Congrats to Canals & Airola teams!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains | PNAS
Hereditary spastic paraplegia subtype SPG54 is a genetic neurological disorder caused
by mutations in the DDHD2 gene. Excessive lipid droplet accum...
www.pnas.org
November 24, 2025 at 9:18 AM
DDHD2, tied to hereditary spastic paraplegia, acts as both a triglyceride lipase and transacylase. While #lipiddroplets don't accumulate in neurons, this raises key questions about fatty acid composition and LD dynamics in these cells. Congrats to Canals & Airola teams!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Thank you ππΏππΏππΏ
November 18, 2025 at 7:38 PM
Thank you ππΏππΏππΏ
Thanks Fikadu!!
November 18, 2025 at 4:26 PM
Thanks Fikadu!!
Thanks Γric!
November 18, 2025 at 4:25 PM
Thanks Γric!
ATG2A = the one who grabs the βwonky greaseβ off the stove (ER) and dumps it into the butter ball (LD) so everything stays chill.
No ATG2A?
Stoveβs a greasy mess and instead of one big happy butter ball you get 1,000 furious mini-butter pellets rolling around like they own the place.
No ATG2A?
Stoveβs a greasy mess and instead of one big happy butter ball you get 1,000 furious mini-butter pellets rolling around like they own the place.
November 18, 2025 at 2:37 PM
ATG2A = the one who grabs the βwonky greaseβ off the stove (ER) and dumps it into the butter ball (LD) so everything stays chill.
No ATG2A?
Stoveβs a greasy mess and instead of one big happy butter ball you get 1,000 furious mini-butter pellets rolling around like they own the place.
No ATG2A?
Stoveβs a greasy mess and instead of one big happy butter ball you get 1,000 furious mini-butter pellets rolling around like they own the place.
Reposted by Abdou Rachid Thiam
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 18, 2025 at 6:20 AM
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Thanks Claudia!
November 18, 2025 at 7:26 AM
Thanks Claudia!
Thank you AndrΓ©.
November 18, 2025 at 7:26 AM
Thank you AndrΓ©.
Work led by the talented PhD student Helin Elhan, and we are incredibly grateful to all our collaborators who made this possible.
November 17, 2025 at 10:57 PM
Work led by the talented PhD student Helin Elhan, and we are incredibly grateful to all our collaborators who made this possible.
* ATG2A functions as a DAG/neutral lipid-transfer bridge at ERβLD contact sites
* This mechanism helps the ER avoid non-bilayer lipid buildup
* Its DAG-transfer activity is essential for DGAT2 targeting and TAG synthesis on LDs
* Loss of ATG2A causes many small LDs; restoring ATG2A rescues LD growth
* This mechanism helps the ER avoid non-bilayer lipid buildup
* Its DAG-transfer activity is essential for DGAT2 targeting and TAG synthesis on LDs
* Loss of ATG2A causes many small LDs; restoring ATG2A rescues LD growth
November 17, 2025 at 10:57 PM
* ATG2A functions as a DAG/neutral lipid-transfer bridge at ERβLD contact sites
* This mechanism helps the ER avoid non-bilayer lipid buildup
* Its DAG-transfer activity is essential for DGAT2 targeting and TAG synthesis on LDs
* Loss of ATG2A causes many small LDs; restoring ATG2A rescues LD growth
* This mechanism helps the ER avoid non-bilayer lipid buildup
* Its DAG-transfer activity is essential for DGAT2 targeting and TAG synthesis on LDs
* Loss of ATG2A causes many small LDs; restoring ATG2A rescues LD growth
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Abdou Rachid Thiam
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, AurΓ©lien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, AurΓ©lien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by Abdou Rachid Thiam
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites https://www.biorxiv.org/content/10.1101/2025.11.06.685814v1
November 7, 2025 at 10:30 PM
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites https://www.biorxiv.org/content/10.1101/2025.11.06.685814v1
Reposted by Abdou Rachid Thiam
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites www.biorxiv.org/content/10.1...
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites
Phosphatidic acid (PA) is a central metabolic intermediate that can fuel triacylglycerol (TAG) synthesis in lipid droplets (LDs) or cardiolipin production in mitochondria, but how cells partition PA b...
www.biorxiv.org
November 8, 2025 at 9:59 PM
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites www.biorxiv.org/content/10.1...
Reposted by Abdou Rachid Thiam
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel KΓΌmmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting
of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor
Ldo16. They uncover a molecular l...
www.cell.com
November 7, 2025 at 2:06 PM
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel KΓΌmmel lab, Thomas Becker lab! www.cell.com/cell-reports...
Reposted by Abdou Rachid Thiam
New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 6, 2025 at 7:47 PM
New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Abdou Rachid Thiam
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
November 6, 2025 at 7:05 PM
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
Reposted by Abdou Rachid Thiam
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 6, 2025 at 9:36 PM
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
Reposted by Abdou Rachid Thiam
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 6:27 PM
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Abdou Rachid Thiam
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
Weβll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Weβll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
Weβll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Weβll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Abdou Rachid Thiam
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Abdou Rachid Thiam
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
October 27, 2025 at 5:02 PM
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Reposted by Abdou Rachid Thiam
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 26, 2025 at 3:04 PM
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted by Abdou Rachid Thiam
π Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the π
Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
October 27, 2025 at 9:28 AM
π Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the π
Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Reposted by Abdou Rachid Thiam
Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.
π Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the π
Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells π§¬β¨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
October 27, 2025 at 10:43 AM
Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.