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ishier.bsky.social
Ishier Raote
@ishier.bsky.social
990 followers 530 following 240 posts
Institut Jacques Monod, Paris @ijmonod.bsky.social https://www.ijm.fr/raote-lab/ Collagen secretion, membrane trafficking Formerly @crg.eu
www.ijm.fr
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Reposted by Ishier Raote
ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 9d
✍️ The Raote Lab ( @ishier.bsky.social ) contributed to the publication of a new article

📖 @natrevmcb.nature.com
📃 Towards a unified framework for the function of endoplasmic reticulum exit sites

🔗 www.nature.com/articles/s41...
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Reposted by Ishier Raote
thibautbrunet.bsky.social
Thibaut Brunet @thibautbrunet.bsky.social · 10d
Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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Reposted by Ishier Raote
akankshi.bsky.social
Akankshi Munjal @akankshi.bsky.social · 19d
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
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Reposted by Ishier Raote
lisaheinke.bsky.social
Lisa Heinke @lisaheinke.bsky.social · 15d
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
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Reposted by Ishier Raote
biologists.bsky.social
The Company of Biologists @biologists.bsky.social · 13d
We are highlighting Cathy Jackson, @biologyopen.bsky.social Deputy Editor and an Editorial Advisory Board member at @jcellsci.bsky.social, as an extraordinary biologist this week. #100biologists @ijmonod.bsky.social
The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Cathy Jackson to the left, text to the right 100 extraordinary biologists Cathy Jackson Cathy Jackson is a Biology Open Deputy Editor and an Editorial Advisory Board member at Journal of Cell Science. Cathy is a Research Director at the Institut Jacques Monod, France, investigating the molecular mechanisms regulating vesicular and lipid trafficking in yeast and mammalian cells. #100biologists #biologists100
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Reposted by Ishier Raote
buzzbaum.bsky.social
Buzz Baum @buzzbaum.bsky.social · 13d
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
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Reposted by Ishier Raote
hessofarhan.bsky.social
Hesso Farhan @hessofarhan.bsky.social · 15d
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
Absolutely! What triggers uncoating, is COPII tethered, do lipids or carrier biomechanics matter, how much fusion/fission occurs en route? Are all fission, uncoating, tethering events the same? Can this be regulated? How do these events vary across cell types or cargo, and what defines their timing?
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
Very exciting. Looking forward to it.
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
Thank you - it was a fun exercise to arrive at a coherent outline given our diverse opinions and future plans!

I've heard it said that biology research has 25-year cycles - what's exciting now is our ability to revisit questions that started being answered 25 years ago. Time for your return!
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
That's a fun couple of sessions! Do share feedback and insights from your reading of the roadmap and from your discussions.
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
@hessofarhan.bsky.social @felixmendu.bsky.social Giulia Zanetti, @saitolab.bsky.social Liang Ge, Koty Hirschberg, Jennifer Lippincott-Schwartz, @aforrester.bsky.social @franckperez.bsky.social Jose Pastor-Pareja Vivek Malhotra
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
Born from a fantastic meeting of the twelve of us — hosted by Hesso Farhan in Innsbruck — this is our deep dive into the fabulous world of ER export. Fresh ideas, new technologies and bold concepts are now solidifying, refining, challenging and expanding on fifty years of rich work in the field.
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 15d
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 20d
TODAY! Mini-symposium with the #MembraneTrafficking webinar series. Join us for exciting cell biology from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías. Keynote lecture from Gillian Griffiths @griffithslab.bsky.social
Don't miss it!
focalplane.biologists.com/2025/09/16/f...
FocalPlane features... membrane trafficking - FocalPlane
FocalPlane features... membrane trafficking - News
focalplane.biologists.com
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Reposted by Ishier Raote
maiblab.bsky.social
Hannes Maib @maiblab.bsky.social · 23d
Really glad to show our recent work using recombinant phosphoinositide probes to investigate membrane identity changes during endosomal trafficking. Should be a great mini symposium to highlight the power of fluorescent microscopy techniques for cell biology!
focalplane.bsky.social
FocalPlane @focalplane.bsky.social · 23d
Join us this Thursday for our mini-symposium with the membrane trafficking webinar series
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
focalplane.biologists.com/2025/09/16/f...
FocalPlane features... membrane trafficking - FocalPlane
FocalPlane features... membrane trafficking - News
focalplane.biologists.com
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Reposted by Ishier Raote
marius-lemberg.bsky.social
Marius Lemberg @marius-lemberg.bsky.social · Jun 7
Just stumbled upon a German tongue-twister song by Bodo Wartke… about the sexiest cell organelle. Yes, endoplasmic reticulum - your moment has come.
youtube.com/shorts/EP5pd...
Das endoplasmatische Retikulum
YouTube video by Bodo Wartke
youtube.com
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Reposted by Ishier Raote
felixmendu.bsky.social
Felix Campelo @felixmendu.bsky.social · 23d
🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...
Mechanical forces stimulate Golgi export
Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...
www.biorxiv.org
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Reposted by Ishier Raote
felixmendu.bsky.social
Felix Campelo @felixmendu.bsky.social · 23d
This is already This Thursday (25th September)! Join us at the @focalplane.bsky.social features #MembraneTrafficking for lots of amazing microscopy and interesting membrane biology! @franbottanelli.bsky.social @ishier.bsky.social @biologists.bsky.social
felixmendu.bsky.social
Felix Campelo @felixmendu.bsky.social · 29d
Next Thursday Sept 25 (4-6pm CET) we have our first #FocalPlaneFeatures together with our #membranetrafficking community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here: focalplane.biologists.com/2025/09/16/f...
FocalPlane features... membrane trafficking Thursday 25 September, 15:00 -17:00 BST (UTC+1) Chaired by Francesca Bottanelli, Felix Campelo and Ishier Raote Nick Ader (UNC Greensboro) Keep it together! Mechanisms of membrane maintenance and biogenesis Hannes Maib (University of Sheffield) Multiplex and super resolution imaging of phosphoinositide conversion during receptor trafficking Mónica Quiñones-Frías (Brandeis University) Loss of ER-Shaping protein Atlastin causes synaptic ER stress and membrane trafficking defects Keynote speaker Gillian Griffiths (Yale University) Unexpected membrane dynamics in T cells
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 23d
My new smartwatch keeps nagging me to destress or to exercise. Honestly, the stress is the watch telling me not to stress.
But I’ve cracked the code: the only time it says I'm relaxed is when I'm in the lab: discussing data, writing a review and reading a preprint. Science is my wellness app.
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · 23d
How do resident Golgi proteins recycle during cisternal maturation? Nice preprint from Adam Krahn in the Glick lab shows different classes of intra-Golgi vesicles in yeast: two COPI-dependent (early and mid) and one late clathrin/AP-1/Ent5 pathway.
www.biorxiv.org/content/10.1...
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Reposted by Ishier Raote
felixmendu.bsky.social
Felix Campelo @felixmendu.bsky.social · 29d
Next Thursday Sept 25 (4-6pm CET) we have our first #FocalPlaneFeatures together with our #membranetrafficking community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here: focalplane.biologists.com/2025/09/16/f...
FocalPlane features... membrane trafficking Thursday 25 September, 15:00 -17:00 BST (UTC+1) Chaired by Francesca Bottanelli, Felix Campelo and Ishier Raote Nick Ader (UNC Greensboro) Keep it together! Mechanisms of membrane maintenance and biogenesis Hannes Maib (University of Sheffield) Multiplex and super resolution imaging of phosphoinositide conversion during receptor trafficking Mónica Quiñones-Frías (Brandeis University) Loss of ER-Shaping protein Atlastin causes synaptic ER stress and membrane trafficking defects Keynote speaker Gillian Griffiths (Yale University) Unexpected membrane dynamics in T cells
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Reposted by Ishier Raote
ibudin.bsky.social
Itay Budin @ibudin.bsky.social · Sep 15
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
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ishier.bsky.social
Ishier Raote @ishier.bsky.social · Sep 15
My office card reader is out of battery, so I can’t get in.
I'm calling this a desk reject.
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Reposted by Ishier Raote
thibautbrunet.bsky.social
Thibaut Brunet @thibautbrunet.bsky.social · Sep 9
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Flagellar gliding in choanoflagellates
Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...
www.cell.com
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