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Alex Holehouse

@alexholehouse.bsky.social

3K followers 1.2K following 250 posts

Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him. https://www.holehouselab.com/

www.holehouselab.com

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Alex Holehouse @alexholehouse.bsky.social · May 23

Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...

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Reposted by Alex Holehouse

David W. Sanders! @davidwsanders.bsky.social · 5d

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

UT Southwestern researcher receives NIH Director’s New Innovator Award

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

www.utsouthwestern.edu

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Reposted by Alex Holehouse

Philip Ball @philipcball.bsky.social · 6d

Musk FRS.

Don Moynihan @donmoyn.bsky.social · 6d

The elimination of USAID is a moral atrocity and all involved made a choice to enable, and then lie about, ending the lives of some of the most vulnerable people in the world.

MAE SOT, Thailand (AP) - Mohammed Taher clutched the lifeless body of his 2-year-old son and wept. Ever since his family's food rations stopped arriving at their internment camp in Myanmar in April, the father had watched helplessly as his once-vibrant baby boy weakened, suffering from diarrhea and begging for food.
On May 21, exactly two weeks after Taher's little boy died, U.S. Secretary of State Marco Rubio sat before Congress and declared: "No one has died" because of his government's decision to gut its foreign aid program. Rubio also insisted: "No children are dying on my watch."
That, Taher says, "is a lie."

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Alex Holehouse @alexholehouse.bsky.social · 12d

Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.

Will stay for the foreseeable future!

BIRDS! EVERYWHERE! GEESE! PEACOCKS! HUMMINGBIRDS!

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Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Martin! Also I'm so sorry I owe you note one but TWO emails!!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Natalie - hugely appreciated... Caipirinhas soon!!!!🍹🍹🍹

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Michelle! Hope you're doing well!!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Professor Lohman!!

Alex Holehouse @alexholehouse.bsky.social · 12d

He is 😂. Never misses a day, works late, and is in early. Perfect colleague.

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Gabriel!! Also, that paper I mentioned in Ascona, looking at surface chemistry of proteins in desiccation, came out like, 30 minutes ago (literally)!
www.cell.com/cell-systems...

Protein surface chemistry encodes an adaptive tolerance to desiccation

Desiccated cells lose over 85% of their water content and experience widespread biomolecular dysfunction. Romero-Pérez et al. show that the yeast proteome contains a subset of proteins that are desicc...

www.cell.com

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Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Seema!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Charlotte!

Alex Holehouse @alexholehouse.bsky.social · 12d

Who are you? 😆

Alex Holehouse @alexholehouse.bsky.social · 12d

The ultimate endpoint is an acronym where none of the letters in the acronym are in any of the words. This is the final boss. We are trying.

Alex Holehouse @alexholehouse.bsky.social · 12d

Hahaha thank Marcin - feels like a long time ago we were sat in first year undergraduate tutorials (because, I suppose, it was a long time ago 😭). REALLY hope we get to catch up in person again soon!!

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Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Alexis!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Kaushik! Much appreciated!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Mark!!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Trevor!! Email response re: meeting up, coming in 3...2...1...

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Mark - and YES 100% agree; I think we're now at a point where these giant IDRs are becoming conceptually accessible for sequence-function links... Would love to re-connect and chat more about this!

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Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Anita!!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Jerelle! And congrats on ALL the recent super cool papers 🥳🥳🥳!

Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks, Tanja - it's also fair to say you have had an extremely outsized impact on getting me here !!! Thanks so much for everything!

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Alex Holehouse @alexholehouse.bsky.social · 12d

Thanks Cathy 😄!

Reposted by Alex Holehouse

Giulio Tesei @giuliotesei.bsky.social · 12d

I'm hiring for a PhD position at Malmö University, Sweden!

The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.

More details and application form: tinyurl.com/4zm92365

Please feel free to share!

@vetenskapsradet.bsky.social | @mau.se

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

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