Cristina Muñoz Pinedo
@crismunozp.bsky.social
Scientist by day, defender of lost causes by night. Especially the right to not spend our lives filling online forms.
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Fast, ISR-independent repression of translation of “old” versus “fresh” RNA (5 min!) in glucose deprived yeast cells
Online Now: Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Online now:
Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress
Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show that the timing of mRNA production alone determines the selectivity of translation, thereby coupling the processes of transcription and translation.
dlvr.it
November 27, 2025 at 10:41 PM
Fast, ISR-independent repression of translation of “old” versus “fresh” RNA (5 min!) in glucose deprived yeast cells
Why, Nature, really?
Because we're always right! Every husband knows
Because we're always right! Every husband knows
November 27, 2025 at 5:42 PM
Why, Nature, really?
Because we're always right! Every husband knows
Because we're always right! Every husband knows
Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different
"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...
"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...
Lipid Composition Alters Ferroptosis Sensitivity
Changes in lipid composition can affect induction of ferroptosis, explaining why sensitivity of cancer cells in tissue culture does not reliably translate to more complex models and suggesting potenti...
aacrjournals.org
November 27, 2025 at 5:12 PM
Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different
"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...
"Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...
“Know this”, he says. “The main function of reviewers and the
Editorial process is to take your lovely, wonderful paper
That you love so much, that you adore
And convert it, step by step, into that which you will call
‘That frogging’ paper.
Editorial process is to take your lovely, wonderful paper
That you love so much, that you adore
And convert it, step by step, into that which you will call
‘That frogging’ paper.
November 21, 2025 at 3:04 PM
“Know this”, he says. “The main function of reviewers and the
Editorial process is to take your lovely, wonderful paper
That you love so much, that you adore
And convert it, step by step, into that which you will call
‘That frogging’ paper.
Editorial process is to take your lovely, wonderful paper
That you love so much, that you adore
And convert it, step by step, into that which you will call
‘That frogging’ paper.
C'mon guys. Cells show blebbing and death was inhibited by caspase inhibitors and had mitochondrial permeabilization.
In my alternate universe, this is apoptosis 🙄
In my alternate universe, this is apoptosis 🙄
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia: Cell www.cell.com/cell/fulltex...
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
Reduced levels of the essential metabolite heme are a common feature of acute myeloid
leukemia, and consequently, leukemic cells are highly sensitive to inhibition of de
novo heme synthesis. Blockade ...
www.cell.com
November 21, 2025 at 2:51 PM
C'mon guys. Cells show blebbing and death was inhibited by caspase inhibitors and had mitochondrial permeabilization.
In my alternate universe, this is apoptosis 🙄
In my alternate universe, this is apoptosis 🙄
RNA damage, ribosome collisions and the MAP3K ZAK www.nature.com/articles/s41...
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 20, 2025 at 2:39 PM
RNA damage, ribosome collisions and the MAP3K ZAK www.nature.com/articles/s41...
With kimchi given in pills! So it’s not even the yummy flavor
12 weeks of kimchi dietary intervention enhanced antigen presentation and remodeled CD4+ T cells without broad systemic activation, providing single-cell evidence of kimchi-induced dietary immunomodulation in humans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 18, 2025 at 9:17 PM
With kimchi given in pills! So it’s not even the yummy flavor
Reposted by Cristina Muñoz Pinedo
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically
remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a
unique pathogen strategy to rewire ...
www.cell.com
November 16, 2025 at 9:09 AM
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Cristina Muñoz Pinedo
This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/...
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a...
www.nature.com
November 16, 2025 at 9:09 AM
This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/...
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Very happy to announce that both my co-PI Ernest Nadal and myself have made it (independently) to the Stanford/Ioannidis 2% c-index ranking!!!
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
L’IDIBELL consolida l’excel·lència científica amb 33 investigadors i investigadores dins la World’s Top 2% Scientists list – IDIBELL
idibell.cat
November 13, 2025 at 11:27 AM
Very happy to announce that both my co-PI Ernest Nadal and myself have made it (independently) to the Stanford/Ioannidis 2% c-index ranking!!!
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
The Matthew effect is extremely strong with ERC grants in some countries. They should study this program separately
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
November 12, 2025 at 11:15 PM
The Matthew effect is extremely strong with ERC grants in some countries. They should study this program separately
Reposted by Cristina Muñoz Pinedo
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Cristina Muñoz Pinedo
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
November 9, 2025 at 6:43 PM
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
and while we're at it, why don't we also stop using MTT, Alamar blue and similar dies to quantify "cell death" in metabolic studies ...
Can we please stop using GAPDH as a "loading control", particularly in metabolic studies??
November 7, 2025 at 11:01 AM
and while we're at it, why don't we also stop using MTT, Alamar blue and similar dies to quantify "cell death" in metabolic studies ...
Good morning everyone!
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
ApoList – October 2025
Crosstalk apoptosis-other forms of cell death Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics Yun Qiu, Juliana A. Hüther, Bianca Wank, Antonia Rath, René Tykwe,…
celldeath.wordpress.com
November 7, 2025 at 10:28 AM
Good morning everyone!
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Reposted by Cristina Muñoz Pinedo
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 5:19 PM
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Reposted by Cristina Muñoz Pinedo
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
November 4, 2025 at 12:18 PM
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
Reposted by Cristina Muñoz Pinedo
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
www.asimov.press
November 3, 2025 at 6:25 PM
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Reposted by Cristina Muñoz Pinedo
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Katharina Leithner and Katharina Schindlmaier just reported the relevance of gluconeogenesis enzymes in macrophages in lung cancer
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Glad to have helped!
www.pnas.org/doi/abs/10.1...
October 30, 2025 at 11:11 PM
Katharina Leithner and Katharina Schindlmaier just reported the relevance of gluconeogenesis enzymes in macrophages in lung cancer
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Reposted by Cristina Muñoz Pinedo
Wie passen sich Immunzellen an Krebs an? Ein Forschungsteam rund um Katharina Schindlmaier und Katharina Leithner hat gezeigt, dass Makrophagen („Fresszellen“) ihren Stoffwechsel selbst unter Glukosemangel aufrechterhalten können – etwa in nährstoffarmen Tumoren: https://shorturl.at/EpIUZ
October 30, 2025 at 2:35 PM
Wie passen sich Immunzellen an Krebs an? Ein Forschungsteam rund um Katharina Schindlmaier und Katharina Leithner hat gezeigt, dass Makrophagen („Fresszellen“) ihren Stoffwechsel selbst unter Glukosemangel aufrechterhalten können – etwa in nährstoffarmen Tumoren: https://shorturl.at/EpIUZ
Reposted by Cristina Muñoz Pinedo
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
October 28, 2025 at 3:58 AM
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
Reposted by Cristina Muñoz Pinedo
👇📃 Nos han aceptado en la REDOC el primer trabajo de mi tesis! "Dos décadas de financiación competitiva en España: un análisis longitudinal del principal instrumento de financiación de proyectos de investigación del Plan Nacional de I+D+i (2004-2023)" (1/9)
October 27, 2025 at 2:52 PM
👇📃 Nos han aceptado en la REDOC el primer trabajo de mi tesis! "Dos décadas de financiación competitiva en España: un análisis longitudinal del principal instrumento de financiación de proyectos de investigación del Plan Nacional de I+D+i (2004-2023)" (1/9)
We (scientists) think we are smart, but we are unable to get past this screen at editorialmanager.com
October 24, 2025 at 2:14 PM
We (scientists) think we are smart, but we are unable to get past this screen at editorialmanager.com
What are you guys using for uploading RNAseq data while GEO from the US Government is not working?
Arrayexpress, other?
Or are most people just waiting?
Arrayexpress, other?
Or are most people just waiting?
October 23, 2025 at 2:25 PM
What are you guys using for uploading RNAseq data while GEO from the US Government is not working?
Arrayexpress, other?
Or are most people just waiting?
Arrayexpress, other?
Or are most people just waiting?