Cristina Muñoz Pinedo
@crismunozp.bsky.social
Scientist by day, defender of lost causes by night. Especially the right to not spend our lives filling online forms.
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Here we go.
bsky.app/profile/cris...
bsky.app/profile/cris...
C'mon guys. Cells show blebbing and death was inhibited by caspase inhibitors and had mitochondrial permeabilization.
In my alternate universe, this is apoptosis 🙄
In my alternate universe, this is apoptosis 🙄
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia: Cell www.cell.com/cell/fulltex...
November 21, 2025 at 2:56 PM
Here we go.
bsky.app/profile/cris...
bsky.app/profile/cris...
"Consistently, time-lapse imaging of elesclomol-treated and FECH knockout or inhibited OCI-AML3 cells showed membrane blebbing, a morphologic feature induced downstream of caspase-3 activation in apoptosis"
Why is this not apoptosis?
Why is this not apoptosis?
November 21, 2025 at 2:53 PM
"Consistently, time-lapse imaging of elesclomol-treated and FECH knockout or inhibited OCI-AML3 cells showed membrane blebbing, a morphologic feature induced downstream of caspase-3 activation in apoptosis"
Why is this not apoptosis?
Why is this not apoptosis?
I object to the title.
"Surprisingly, the pan-caspase inhibitor emricasan also partially rescued NMP- and elesclomol-induced killing. These observations suggest leakage of mitochondrial contents, such as cytochrome c or Smac, caused by NMP and elesclomol activating the caspase cascade. "
"Surprisingly, the pan-caspase inhibitor emricasan also partially rescued NMP- and elesclomol-induced killing. These observations suggest leakage of mitochondrial contents, such as cytochrome c or Smac, caused by NMP and elesclomol activating the caspase cascade. "
November 21, 2025 at 2:52 PM
I object to the title.
"Surprisingly, the pan-caspase inhibitor emricasan also partially rescued NMP- and elesclomol-induced killing. These observations suggest leakage of mitochondrial contents, such as cytochrome c or Smac, caused by NMP and elesclomol activating the caspase cascade. "
"Surprisingly, the pan-caspase inhibitor emricasan also partially rescued NMP- and elesclomol-induced killing. These observations suggest leakage of mitochondrial contents, such as cytochrome c or Smac, caused by NMP and elesclomol activating the caspase cascade. "
He acertado!!!
November 21, 2025 at 10:04 AM
He acertado!!!
Reposted by Cristina Muñoz Pinedo
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically
remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a
unique pathogen strategy to rewire ...
www.cell.com
November 16, 2025 at 9:09 AM
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
This is not a journal-based metric
Congrats IRB
Congrats IRB
November 13, 2025 at 12:02 AM
This is not a journal-based metric
Congrats IRB
Congrats IRB