Kateryna Shkarina
@kshkarina.bsky.social
PostDoc in Eicke Latz lab @iii Bonn (previously - PhD @brozlab.bsky.social) working on inflammasomes and cell death and their role in inflammation and tissue repair. Passionate about all things #microscopy, #optogenetics and #cycling 🔬🚴🏼♀️.
Reposted by Kateryna Shkarina
🧬 Have you taken the survey yet?
EFIS, yEFIS & University of Exeter want to hear from anyone working in immunology.
https://loom.ly/Ud8A7s4
@efis-immunology.bsky.social
@yefis-immunology.bsky.social
EFIS, yEFIS & University of Exeter want to hear from anyone working in immunology.
https://loom.ly/Ud8A7s4
@efis-immunology.bsky.social
@yefis-immunology.bsky.social
November 22, 2025 at 9:00 AM
🧬 Have you taken the survey yet?
EFIS, yEFIS & University of Exeter want to hear from anyone working in immunology.
https://loom.ly/Ud8A7s4
@efis-immunology.bsky.social
@yefis-immunology.bsky.social
EFIS, yEFIS & University of Exeter want to hear from anyone working in immunology.
https://loom.ly/Ud8A7s4
@efis-immunology.bsky.social
@yefis-immunology.bsky.social
Reposted by Kateryna Shkarina
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria:
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria
Alternative to the formation of NETs, André et al. describe here that viable neutrophils
may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF
formation is associated wi...
www.cell.com
November 23, 2025 at 9:30 AM
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria:
NLRP6 as a sensor of sterile or pathogen-induced endolysosomal damage:
The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal
imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and
viruses in the gastrointestinal tract by a poorly-understood mechanism. This study
shows that NLRP6 forms...
www.embopress.org
November 23, 2025 at 9:30 AM
NLRP6 as a sensor of sterile or pathogen-induced endolysosomal damage:
This week´s issue of BiomedNews on everything related to #CellDeath and its consequences: biomed.news/bims-cediti/...
Some highlights:
RIOK2 as potentially new regulator of caspase-8 dependent pyroptosis following Yersinia infection:
Some highlights:
RIOK2 as potentially new regulator of caspase-8 dependent pyroptosis following Yersinia infection:
RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis - Nature Communications
Macrophage infection by Yersinia or specific stimulations trigger caspase-8-mediated GSDMD cleavage. RIOK2 kinase is essential for this process by interacting with FADD and driving the lysosome-to-ER ...
www.nature.com
November 23, 2025 at 9:30 AM
This week´s issue of BiomedNews on everything related to #CellDeath and its consequences: biomed.news/bims-cediti/...
Some highlights:
RIOK2 as potentially new regulator of caspase-8 dependent pyroptosis following Yersinia infection:
Some highlights:
RIOK2 as potentially new regulator of caspase-8 dependent pyroptosis following Yersinia infection:
Reposted by Kateryna Shkarina
Image screening is going to fail. We need audit trails for data provenance.
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 22, 2025 at 4:21 PM
Image screening is going to fail. We need audit trails for data provenance.
Resources such as Human Protein Atlas rely on antibodies to map protein expression or intracellular localisation, but bad or unvalidated antibodies can misinform and derail research projects by giving false or unreproducible results.
How can we make antibodies better and more reliable? 👇
How can we make antibodies better and more reliable? 👇
Bad antibodies are a major roadblock in biomedical research, harming reproducibility and wasting resources.
The International Antibody Validation Meeting was created to fix it.
Watch the talks from the 5th Antibody Validation Meeting (2025)
tinyurl.com/AntibodyVali...
#Integrity #reproducibility
The International Antibody Validation Meeting was created to fix it.
Watch the talks from the 5th Antibody Validation Meeting (2025)
tinyurl.com/AntibodyVali...
#Integrity #reproducibility
5th International Antibody Validation Meeting - YouTube
Listen to talks from the speakers at the 5th AbVal meeting, held in Bath on the 9-11th September 2025.
tinyurl.com
November 22, 2025 at 11:10 AM
Resources such as Human Protein Atlas rely on antibodies to map protein expression or intracellular localisation, but bad or unvalidated antibodies can misinform and derail research projects by giving false or unreproducible results.
How can we make antibodies better and more reliable? 👇
How can we make antibodies better and more reliable? 👇
Reposted by Kateryna Shkarina
🚨 Postdoc position in my lab!
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
November 21, 2025 at 4:44 PM
🚨 Postdoc position in my lab!
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Reposted by Kateryna Shkarina
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Congratulations Alexandra!
November 20, 2025 at 5:00 PM
Congratulations Alexandra!
New insights into the activation of the most elusive and (so far) the least understood human inflammasome: NLRP6 is a sensor of endolysosomal damage
November 20, 2025 at 4:59 PM
New insights into the activation of the most elusive and (so far) the least understood human inflammasome: NLRP6 is a sensor of endolysosomal damage
Reposted by Kateryna Shkarina
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
November 20, 2025 at 3:29 PM
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
Reposted by Kateryna Shkarina
We are hiring a postdoc! 🧪
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
Career Opportunities: Postdoctoral position in cellular metabolism (22584)
tinyurl.com
November 20, 2025 at 6:26 AM
We are hiring a postdoc! 🧪
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
Reposted by Kateryna Shkarina
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
Reposted by Kateryna Shkarina
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Another important observation from two recent papers: a commonly used Caspase-1 inhibitor VX-765 is less specific than thought and exhibits off-target effects on other caspases: www.frontiersin.org/journals/imm...
pubs.acs.org/doi/full/10.....
pubs.acs.org/doi/full/10.....
November 16, 2025 at 9:09 AM
Another important observation from two recent papers: a commonly used Caspase-1 inhibitor VX-765 is less specific than thought and exhibits off-target effects on other caspases: www.frontiersin.org/journals/imm...
pubs.acs.org/doi/full/10.....
pubs.acs.org/doi/full/10.....
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically
remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a
unique pathogen strategy to rewire ...
www.cell.com
November 16, 2025 at 9:09 AM
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Highlight 2:
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes - Nature Immunology
Lamkanfi, Shirasaki, Izawa and colleagues show that IL-1β release in human monocytes stimulated with lipopolysaccharide or carrying NLRP3 activatory mutations is mostly restricted to cells undergoing ...
www.nature.com
November 16, 2025 at 9:09 AM
Highlight 2:
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/...
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a...
www.nature.com
November 16, 2025 at 9:09 AM
This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/...
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:
Even rare #CellDeath events matter: a new study from Lamkanfi lab shows that small fraction of pyroptotic monocytes accounts for the most of IL-1β production following LPS stimulation, challenging the previously proposed models of IL-1β secretion from the living cells:
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes - Nature Immunology
Lamkanfi, Shirasaki, Izawa and colleagues show that IL-1β release in human monocytes stimulated with lipopolysaccharide or carrying NLRP3 activatory mutations is mostly restricted to cells undergoing ...
www.nature.com
November 14, 2025 at 10:55 AM
Even rare #CellDeath events matter: a new study from Lamkanfi lab shows that small fraction of pyroptotic monocytes accounts for the most of IL-1β production following LPS stimulation, challenging the previously proposed models of IL-1β secretion from the living cells:
Yes it is!!! I also love that it can hold both eppies and PCR tubes, super convenient 🤩
November 12, 2025 at 11:47 AM
Yes it is!!! I also love that it can hold both eppies and PCR tubes, super convenient 🤩
Reposted by Kateryna Shkarina
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
This reminds me so much of the end of my Ph.D. 😆 (minus this super-cool pink rack - love this one!)
November 12, 2025 at 9:10 AM
This reminds me so much of the end of my Ph.D. 😆 (minus this super-cool pink rack - love this one!)
Reposted by Kateryna Shkarina
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa
lnkd.in
November 11, 2025 at 6:20 AM
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Reposted by Kateryna Shkarina
Correct link: www.findaphd.com/phds/?Keywor...
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 7:47 PM
Correct link: www.findaphd.com/phds/?Keywor...