Kateryna Shkarina
@kshkarina.bsky.social
PostDoc in Eicke Latz lab @iii Bonn (previously - PhD @brozlab.bsky.social) working on inflammasomes and cell death and their role in inflammation and tissue repair. Passionate about all things #microscopy, #optogenetics and #cycling 🔬🚴🏼♀️.
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria:
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria
Alternative to the formation of NETs, André et al. describe here that viable neutrophils
may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF
formation is associated wi...
www.cell.com
November 23, 2025 at 9:30 AM
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria:
NLRP6 as a sensor of sterile or pathogen-induced endolysosomal damage:
The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal
imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and
viruses in the gastrointestinal tract by a poorly-understood mechanism. This study
shows that NLRP6 forms...
www.embopress.org
November 23, 2025 at 9:30 AM
NLRP6 as a sensor of sterile or pathogen-induced endolysosomal damage:
Congratulations Alexandra!
November 20, 2025 at 5:00 PM
Congratulations Alexandra!
Another important observation from two recent papers: a commonly used Caspase-1 inhibitor VX-765 is less specific than thought and exhibits off-target effects on other caspases: www.frontiersin.org/journals/imm...
pubs.acs.org/doi/full/10.....
pubs.acs.org/doi/full/10.....
November 16, 2025 at 9:09 AM
Another important observation from two recent papers: a commonly used Caspase-1 inhibitor VX-765 is less specific than thought and exhibits off-target effects on other caspases: www.frontiersin.org/journals/imm...
pubs.acs.org/doi/full/10.....
pubs.acs.org/doi/full/10.....
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically
remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a
unique pathogen strategy to rewire ...
www.cell.com
November 16, 2025 at 9:09 AM
Highlight 3: Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Highlight 2:
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes - Nature Immunology
Lamkanfi, Shirasaki, Izawa and colleagues show that IL-1β release in human monocytes stimulated with lipopolysaccharide or carrying NLRP3 activatory mutations is mostly restricted to cells undergoing ...
www.nature.com
November 16, 2025 at 9:09 AM
Highlight 2:
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
www.nature.com/articles/s41...
Yes it is!!! I also love that it can hold both eppies and PCR tubes, super convenient 🤩
November 12, 2025 at 11:47 AM
Yes it is!!! I also love that it can hold both eppies and PCR tubes, super convenient 🤩
This reminds me so much of the end of my Ph.D. 😆 (minus this super-cool pink rack - love this one!)
November 12, 2025 at 9:10 AM
This reminds me so much of the end of my Ph.D. 😆 (minus this super-cool pink rack - love this one!)
Reposted by Kateryna Shkarina
Correct link: www.findaphd.com/phds/?Keywor...
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 7:47 PM
Correct link: www.findaphd.com/phds/?Keywor...