Titus Brown
@titus.idyll.org
I am not a deep man, but I have many shallows. [email protected], http://ivory.idyll.org/blog/.
Reposted by Titus Brown
Ain’t I been telling you the reactionary backlash was driven by the very rich and powerful watching regular people use social media to accuse Harvey Weinstein of sex crimes, then watching him dragged sobbing to jail, unprotected by his enormous wealth? What do you think the cancel culture panic was.
January 31, 2026 at 9:19 AM
Ain’t I been telling you the reactionary backlash was driven by the very rich and powerful watching regular people use social media to accuse Harvey Weinstein of sex crimes, then watching him dragged sobbing to jail, unprotected by his enormous wealth? What do you think the cancel culture panic was.
Reposted by Titus Brown
"trio-based long-read phasing method that integrates multi-k-mer parent-specific markers with an alignment-free k-mer lookup engine and a random forest classifier to assign long reads to maternal, paternal, or unknown haplotypes prior to de novo assembly"
Accurate haplotype-resolved de novo assembly of human genomes with RFhap https://www.biorxiv.org/content/10.64898/2026.01.28.702238v1
January 30, 2026 at 11:49 PM
"trio-based long-read phasing method that integrates multi-k-mer parent-specific markers with an alignment-free k-mer lookup engine and a random forest classifier to assign long reads to maternal, paternal, or unknown haplotypes prior to de novo assembly"
Reposted by Titus Brown
Everyone needs to read “Waging a Good War.”
It’s short, informative, and explains the brilliant tactical reasoning that the civil rights leaders used - including “intentionally getting arrested.”
It’s short, informative, and explains the brilliant tactical reasoning that the civil rights leaders used - including “intentionally getting arrested.”
January 31, 2026 at 1:34 AM
Everyone needs to read “Waging a Good War.”
It’s short, informative, and explains the brilliant tactical reasoning that the civil rights leaders used - including “intentionally getting arrested.”
It’s short, informative, and explains the brilliant tactical reasoning that the civil rights leaders used - including “intentionally getting arrested.”
Reposted by Titus Brown
CNN in Minneapolis: We are seeing thousands and thousands of people, we've been standing on the corner here for the past ten minutes. This this crowd has not let up. It's just continuous.
January 30, 2026 at 9:19 PM
CNN in Minneapolis: We are seeing thousands and thousands of people, we've been standing on the corner here for the past ten minutes. This this crowd has not let up. It's just continuous.
Reposted by Titus Brown
Firmly believe this would serve multiple needs.
January 29, 2026 at 9:32 PM
Firmly believe this would serve multiple needs.
Reposted by Titus Brown
Anyway congrats to our Free Speech Champions(tm) who helped usher in the most censorious American government since the Palmer Raids
January 30, 2026 at 1:23 PM
Anyway congrats to our Free Speech Champions(tm) who helped usher in the most censorious American government since the Palmer Raids
Reposted by Titus Brown
there's this new dynamic where the DOJ cannot win in court and is (relatedly) incapable of meeting the minimum threshold of professional legal conduct, and so an increasing percentage of its actions are purely for intimidation and content
January 30, 2026 at 1:54 PM
there's this new dynamic where the DOJ cannot win in court and is (relatedly) incapable of meeting the minimum threshold of professional legal conduct, and so an increasing percentage of its actions are purely for intimidation and content
Reposted by Titus Brown
I’m hoping somebody will tell me how to turn off this bad behavior (I thought I was the only one being annoyed at it). If you have multiple windows open with multiple screens, it results in frantic “where did you go???” expletives.
January 29, 2026 at 8:52 PM
I’m hoping somebody will tell me how to turn off this bad behavior (I thought I was the only one being annoyed at it). If you have multiple windows open with multiple screens, it results in frantic “where did you go???” expletives.
Folks, I am frustrated and challenged by Preview behavior on my Mac. The biggest problem is things open in the wrong (non-primary) window all the time & focus doesn't switch, but there other frustrating things too. Suggestions for a replacement PDF viewer? Or has this been fixed in recent releases?
January 29, 2026 at 8:27 PM
Folks, I am frustrated and challenged by Preview behavior on my Mac. The biggest problem is things open in the wrong (non-primary) window all the time & focus doesn't switch, but there other frustrating things too. Suggestions for a replacement PDF viewer? Or has this been fixed in recent releases?
Look, speaking as a person squarely in that demographic, we are ready for this better kind of radicalization!!
every time i see a white guy in their fifties radicalized by the twitter algorithm into racism and extremism i think about how it's a total failure of the youtube algorithm to instead radicalize him into home brewing, elaborate A/V setups, or DIY solar
January 29, 2026 at 8:04 PM
Look, speaking as a person squarely in that demographic, we are ready for this better kind of radicalization!!
Reposted by Titus Brown
every time i see a white guy in their fifties radicalized by the twitter algorithm into racism and extremism i think about how it's a total failure of the youtube algorithm to instead radicalize him into home brewing, elaborate A/V setups, or DIY solar
January 28, 2026 at 8:22 PM
every time i see a white guy in their fifties radicalized by the twitter algorithm into racism and extremism i think about how it's a total failure of the youtube algorithm to instead radicalize him into home brewing, elaborate A/V setups, or DIY solar
Reposted by Titus Brown
The massive government funding package just failed badly in the Senate, 45-55.
Needed 60.
Zero Democrats voted for it.
SEVEN Republicans opposed it:
Budd
Johnson
Lee
Paul
Moody
Rick Scott
Tuberville
(John Thune switched his vote to no for procedural reasons.)
Needed 60.
Zero Democrats voted for it.
SEVEN Republicans opposed it:
Budd
Johnson
Lee
Paul
Moody
Rick Scott
Tuberville
(John Thune switched his vote to no for procedural reasons.)
January 29, 2026 at 5:27 PM
The massive government funding package just failed badly in the Senate, 45-55.
Needed 60.
Zero Democrats voted for it.
SEVEN Republicans opposed it:
Budd
Johnson
Lee
Paul
Moody
Rick Scott
Tuberville
(John Thune switched his vote to no for procedural reasons.)
Needed 60.
Zero Democrats voted for it.
SEVEN Republicans opposed it:
Budd
Johnson
Lee
Paul
Moody
Rick Scott
Tuberville
(John Thune switched his vote to no for procedural reasons.)
Reposted by Titus Brown
It's the gamergate playbook
It's just the same playbook: harp on a single point, create a Potemkin citation which "disproves" something, point all your bros to it, sow FUD until people outside of the community of practice feel like the issue is not settled.
January 29, 2026 at 7:02 PM
It's the gamergate playbook
Reposted by Titus Brown
When did you start to lose your humanity
And let the monster in?
When did lust for blood overpower you
And soak you in its sin?
How can you call yourself a good Christian
When you're no longer hearing His Word?
Why refuse to welcome the stranger
And join the violent herd?
And let the monster in?
When did lust for blood overpower you
And soak you in its sin?
How can you call yourself a good Christian
When you're no longer hearing His Word?
Why refuse to welcome the stranger
And join the violent herd?
January 29, 2026 at 6:51 PM
When did you start to lose your humanity
And let the monster in?
When did lust for blood overpower you
And soak you in its sin?
How can you call yourself a good Christian
When you're no longer hearing His Word?
Why refuse to welcome the stranger
And join the violent herd?
And let the monster in?
When did lust for blood overpower you
And soak you in its sin?
How can you call yourself a good Christian
When you're no longer hearing His Word?
Why refuse to welcome the stranger
And join the violent herd?
Reposted by Titus Brown
This isn't finished, but with ICE's depredations, it's something I had to put into words. Three verses so far.
How do you face your kids in the evening?
What do you say to your wife?
When you spent your day beating Black and Brown people
And ruining the rest of their life?
How do you face your kids in the evening?
What do you say to your wife?
When you spent your day beating Black and Brown people
And ruining the rest of their life?
January 29, 2026 at 6:51 PM
This isn't finished, but with ICE's depredations, it's something I had to put into words. Three verses so far.
How do you face your kids in the evening?
What do you say to your wife?
When you spent your day beating Black and Brown people
And ruining the rest of their life?
How do you face your kids in the evening?
What do you say to your wife?
When you spent your day beating Black and Brown people
And ruining the rest of their life?
Reposted by Titus Brown
Calling all OrthoFinder users!
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
www.biorxiv.org
January 29, 2026 at 12:07 PM
Calling all OrthoFinder users!
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
Reposted by Titus Brown
🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/wDJrzLu
January 29, 2026 at 2:44 PM
🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/wDJrzLu
Reposted by Titus Brown
Been writing about this for a long time. 2022
January 29, 2026 at 2:45 PM
Been writing about this for a long time. 2022
How titus organizes computational projects: a (very) short presentation. Comments welcome ;)
How titus organizes things - HackMD
tags: bcb298
hackmd.io
January 28, 2026 at 9:40 PM
How titus organizes computational projects: a (very) short presentation. Comments welcome ;)
Reposted by Titus Brown
The Minneapolis resistance, as Renee Good showed, formed quickly because it built on the backs of people who were already doing food drives, school board organizing, and other community work. And those groups are 80% female, I'm guessing. If not more.
They underestimated women. And it bit them.
They underestimated women. And it bit them.
January 28, 2026 at 8:23 PM
The Minneapolis resistance, as Renee Good showed, formed quickly because it built on the backs of people who were already doing food drives, school board organizing, and other community work. And those groups are 80% female, I'm guessing. If not more.
They underestimated women. And it bit them.
They underestimated women. And it bit them.
Reposted by Titus Brown
it seems minor but it’s the fastest way to break the rank and file, and it’ll happen almost immediately. taking away the masks is turning on the lights and watching the cockroaches scatter
Honestly I think if the Dems could somehow win a mask ban for federal agents, I think it would be a huge start. The impunity these dipshits feel being masked up is palpable.
January 28, 2026 at 8:04 PM
it seems minor but it’s the fastest way to break the rank and file, and it’ll happen almost immediately. taking away the masks is turning on the lights and watching the cockroaches scatter
Reposted by Titus Brown
"The end justifies the means. But what if there never is an end? All we have is means." ― Ursula K. Le Guin, The Lathe of Heaven
January 28, 2026 at 6:50 PM
"The end justifies the means. But what if there never is an end? All we have is means." ― Ursula K. Le Guin, The Lathe of Heaven
#microbiome friends, is there a database of cultured microbes that is readily searchable? Or a simple way to limit NCBI searches to cultured microbes?
January 28, 2026 at 7:35 PM
#microbiome friends, is there a database of cultured microbes that is readily searchable? Or a simple way to limit NCBI searches to cultured microbes?
Reposted by Titus Brown
Just started doing new data analysis and I know I keep saying this, but: I really, really don't think people appreciate how much this moral panic was a deliberate and extremely expensive invention.
January 28, 2026 at 3:12 AM
Just started doing new data analysis and I know I keep saying this, but: I really, really don't think people appreciate how much this moral panic was a deliberate and extremely expensive invention.
Reposted by Titus Brown
This was an interesting experiment in using JupyterHub to deploy a *data science design* environment, for a user workshop, rather than a typical "notebook analytics" environment. You can serve all kinds of interfaces and side-applications with JupyterHub!
We helped STRUDEL run a workshop where 30+ researchers prototyped building scientific web applications in a single day. Everyone left with a working prototype, even folks who'd never built a web app before!
2i2c.org/blog/strudel...
2i2c.org/blog/strudel...
STRUDEL enables rapid scientific GUI prototyping in partnership with 2i2c | 2i2c
What happened # The STRUDEL team hosted an all-day workshop with over thirty participants prototyping web applications using the STRUDEL Design System and AI assistants in a custom hub environment…
2i2c.org
January 28, 2026 at 5:26 PM
This was an interesting experiment in using JupyterHub to deploy a *data science design* environment, for a user workshop, rather than a typical "notebook analytics" environment. You can serve all kinds of interfaces and side-applications with JupyterHub!