SusanK
@susankleinfelter.bsky.social
Protein folding nerd, curmudgeon, UW IPD. She/her.
Reposted by SusanK
It’s time for our one sale of the year! Take 20% off with code holiday20 (ends 12/2/2025). The sale includes all of our puzzles and most of our jewelry n-e-r-v-o-u-s.com/shop
November 28, 2025 at 9:45 PM
It’s time for our one sale of the year! Take 20% off with code holiday20 (ends 12/2/2025). The sale includes all of our puzzles and most of our jewelry n-e-r-v-o-u-s.com/shop
Reposted by SusanK
Starbucks employees escalated their strike on Black Friday, expanding to 120 stores and 85 cities.
Their CEO took home $96 million while refusing to negotiate a living wage for workers.
Boycott Starbucks. Stand with the employees.
Support local independent coffee shops:
Their CEO took home $96 million while refusing to negotiate a living wage for workers.
Boycott Starbucks. Stand with the employees.
Support local independent coffee shops:
Starbucks workers' union escalates strike on Black Friday
() -The Starbucks workers' union said on Friday it is escalating an indefinite strike to more than 120 stores and 85 cities, demanding higher pay and staffing levels at the coffee chain. The walkout,...
www.yahoo.com
November 28, 2025 at 9:46 PM
Starbucks employees escalated their strike on Black Friday, expanding to 120 stores and 85 cities.
Their CEO took home $96 million while refusing to negotiate a living wage for workers.
Boycott Starbucks. Stand with the employees.
Support local independent coffee shops:
Their CEO took home $96 million while refusing to negotiate a living wage for workers.
Boycott Starbucks. Stand with the employees.
Support local independent coffee shops:
Reposted by SusanK
Disabled people deserve healthcare.
Disabled people deserve housing.
Disabled people deserve food.
Disabled people deserve support.
Our ability to work and produce for capitalism should not determine our value.
Disability is not a moral failing. Most people will experience it someday.
Disabled people deserve housing.
Disabled people deserve food.
Disabled people deserve support.
Our ability to work and produce for capitalism should not determine our value.
Disability is not a moral failing. Most people will experience it someday.
November 28, 2025 at 4:24 AM
Disabled people deserve healthcare.
Disabled people deserve housing.
Disabled people deserve food.
Disabled people deserve support.
Our ability to work and produce for capitalism should not determine our value.
Disability is not a moral failing. Most people will experience it someday.
Disabled people deserve housing.
Disabled people deserve food.
Disabled people deserve support.
Our ability to work and produce for capitalism should not determine our value.
Disability is not a moral failing. Most people will experience it someday.
Reposted by SusanK
Mini-agrin prevents calcium leakage and restores the dystrophin complex. https://www.biorxiv.org/content/10.1101/2025.11.25.690165v1
November 28, 2025 at 8:30 PM
Mini-agrin prevents calcium leakage and restores the dystrophin complex. https://www.biorxiv.org/content/10.1101/2025.11.25.690165v1
Reposted by SusanK
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 4:43 PM
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Reposted by SusanK
📚 50% off ebooks because capitalism i guess
use code UGHFINE
or you could just buy them! up to you 📚
www.neonhemlock.com/ebooks
use code UGHFINE
or you could just buy them! up to you 📚
www.neonhemlock.com/ebooks
November 28, 2025 at 6:01 PM
📚 50% off ebooks because capitalism i guess
use code UGHFINE
or you could just buy them! up to you 📚
www.neonhemlock.com/ebooks
use code UGHFINE
or you could just buy them! up to you 📚
www.neonhemlock.com/ebooks
Reposted by SusanK
The mechanism of Lamassu, an abundant bacterial immune system, is now solved
Lamassu evolved from a DNA repair complex
Beautiful study from the Patel, Bernheim and Sternberg labs
Lamassu evolved from a DNA repair complex
Beautiful study from the Patel, Bernheim and Sternberg labs
🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
November 27, 2025 at 7:08 PM
The mechanism of Lamassu, an abundant bacterial immune system, is now solved
Lamassu evolved from a DNA repair complex
Beautiful study from the Patel, Bernheim and Sternberg labs
Lamassu evolved from a DNA repair complex
Beautiful study from the Patel, Bernheim and Sternberg labs
Reposted by SusanK
A *huge* vaccine victory. I've been writing on this for years; Australia has seen remarkable progress in cervical cancer prevention with the HPV vaccine. I love seeing science triumph like this.
Australia recorded ZERO cases of cervical cancer in women under 25 for the first time since they started tracking the cancer in the 80s.
This is the power of vaccines.
The HPV vaccine is extremely effective at preventing cancer.
Viruses can be oncogenic. Get your vaccines and protect yourself!
This is the power of vaccines.
The HPV vaccine is extremely effective at preventing cancer.
Viruses can be oncogenic. Get your vaccines and protect yourself!
newsGP - Australia set for world-first cervical cancer elimination
Vaccination programs have played a key role, and GPs remain ‘instrumental’ in boosting screening rates to reach the 2035 target.
www1.racgp.org.au
November 27, 2025 at 6:12 PM
A *huge* vaccine victory. I've been writing on this for years; Australia has seen remarkable progress in cervical cancer prevention with the HPV vaccine. I love seeing science triumph like this.
Reposted by SusanK
PSA
It's ok to feed your autistic kid nuggets today.
It's ok to let your kid be alone in their room while the rest of the family is having dinner.
It's ok to let them be autistic without judgment.
They get enough of that from the rest of the world. ❤️
It's ok to feed your autistic kid nuggets today.
It's ok to let your kid be alone in their room while the rest of the family is having dinner.
It's ok to let them be autistic without judgment.
They get enough of that from the rest of the world. ❤️
November 27, 2025 at 6:41 PM
PSA
It's ok to feed your autistic kid nuggets today.
It's ok to let your kid be alone in their room while the rest of the family is having dinner.
It's ok to let them be autistic without judgment.
They get enough of that from the rest of the world. ❤️
It's ok to feed your autistic kid nuggets today.
It's ok to let your kid be alone in their room while the rest of the family is having dinner.
It's ok to let them be autistic without judgment.
They get enough of that from the rest of the world. ❤️
Reposted by SusanK
Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and a hyperthermic nouse model 🦠 www.science.org/doi/10.1126/...
#flu
#flu
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 7:38 PM
Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and a hyperthermic nouse model 🦠 www.science.org/doi/10.1126/...
#flu
#flu
Today and every day I am thankful for people who love doing science and people who love sharing science!
GOOD NEWS! Researchers have developed a heteromultivalent nanogel capable of killing some of the most dangerous bacteria known to medicine- with over 99.9% effectiveness against P. aeruginosa. It also showed strong antibacterial effects against other major threats, including E. coli and MRSA.
November 27, 2025 at 8:16 PM
Today and every day I am thankful for people who love doing science and people who love sharing science!
Reposted by SusanK
"This future cannot come fast enough,” says Seattle Hub's Jesse Gray.
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
November 27, 2025 at 12:19 AM
"This future cannot come fast enough,” says Seattle Hub's Jesse Gray.
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
Reposted by SusanK
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
November 26, 2025 at 3:06 PM
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Reposted by SusanK
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
November 25, 2025 at 3:01 AM
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
Reposted by SusanK
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
November 25, 2025 at 1:59 AM
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
Reposted by SusanK
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:56 PM
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
Reposted by SusanK
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted by SusanK
Oh my gosh. This is... A thing. Please allow a microbiologist who has played with the microbe that makes this to waffle on for a bit in a short thread. (1)
British and Australian chemists have discovered a powerful new antibiotic called pre-methylenomycin C lactone, hiding in a well-known soil bacterium. This molecule kills drug-resistant bacteria without triggering resistance. buff.ly/YlXaONo
#ShareGoodNewsToo
#ShareGoodNewsToo
Scientists find hidden antibiotic 100x stronger against deadly superbugs
A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It…
buff.ly
November 16, 2025 at 8:02 PM
Oh my gosh. This is... A thing. Please allow a microbiologist who has played with the microbe that makes this to waffle on for a bit in a short thread. (1)
Reposted by SusanK
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
Clathrin adaptors drive phase separation in endocytosis and trafficking
Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize cellular processes, including endocytosis and membrane trafficking. Although LLPS has been impli...
www.biorxiv.org
November 21, 2025 at 10:13 AM
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
Reposted by SusanK
“It would be a senseless act of cruelty to kill the poor spider just because of my irrational fear,” Hapworth explained. “But obviously I’m not going anywhere near the horrible fucking thing.”
Autistic woman who won’t hurt spider gives it exclusive use of kitchen instead
An autistic woman has surrendered use of her kitchen after finding a spider on the linoleum floor, sources have revealed. Beth Hapworth, 32, reports that she was too frightened to move the spider…
thedailytism.com
November 22, 2025 at 10:01 AM
“It would be a senseless act of cruelty to kill the poor spider just because of my irrational fear,” Hapworth explained. “But obviously I’m not going anywhere near the horrible fucking thing.”
Reposted by SusanK
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
November 17, 2025 at 5:39 PM
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Reposted by SusanK
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome
Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and stat...
doi.org
November 19, 2025 at 10:43 AM
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Reposted by SusanK
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by SusanK
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by SusanK
Insanely cool discovery!
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 19, 2025 at 6:13 AM
Insanely cool discovery!