Philipp Niethammer
@niethammerlab.bsky.social
Cell biologist interested in how tissues sense and adapt to physical and chemical stress. Wound healing and regeneration. Quantitative imaging approaches. Nuclear mechanotransduction, ROS signaling & metabolism. All opinions are my own.
Pinned
DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway
During the innate immune response at epithelial wound sites, oxidative stress acts microbicidal and - mechanistically less well understood - as an immune and resilience signal. The reversible sulfhydr...
www.biorxiv.org
While the US science ship is shaking, on a brighter note: two new preprints from the lab. In the first, we identify a long sought, enzyme of eicosanoid metabolism, 5-HEDH, which regulates inflammatory lipid synthesis and breakdown as a function of tissue redox state.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Very interesting data!
Divergence of immune cell types in chordate blood
Innate immune cells are found in almost all metazoans, but the evolution and conservation
of these cells is poorly characterized. Scully et al. present a transcriptional and
morphological atlas of blo...
www.cell.com
November 18, 2025 at 6:26 PM
Very interesting data!
If you are interested in persuing a PhD in basic biology or bioengeneering, check out our MSK graduate school. MSKCC runs two highly curated PhD programs that cater to open-minded students curious about applied or fundamental biological research.
Training Tomorrow’s Leaders: Graduate Education at GSK
Since its founding 19 years ago, the Gerstner Sloan Kettering Graduate School of Biomedical Sciences has attracted bright minds drawn to its connection to MSK. Learn more about how we're training tomo...
www.mskcc.org
November 18, 2025 at 4:22 PM
If you are interested in persuing a PhD in basic biology or bioengeneering, check out our MSK graduate school. MSKCC runs two highly curated PhD programs that cater to open-minded students curious about applied or fundamental biological research.
Thrilled to visit my old postdoctoral home-base, where I spent some of the most exciting years of my career in Tim Mitchison’s lab! sysbio.med.harvard.edu
Systems Biology
sysbio.med.harvard.edu
November 16, 2025 at 10:05 PM
Thrilled to visit my old postdoctoral home-base, where I spent some of the most exciting years of my career in Tim Mitchison’s lab! sysbio.med.harvard.edu
Reposted by Philipp Niethammer
What kind of cognitive complexity can a cell display? What is the role played by nonlinear dynamics of signalling networks? Check this wonderful review paper by Aneta Koseska @koseskalab.bsky.social & Philippe Bastiaens @jgojalvo.bsky.social @jordiplam.bsky.social www.embopress.org/doi/pdf/10.1...
June 3, 2025 at 10:56 AM
What kind of cognitive complexity can a cell display? What is the role played by nonlinear dynamics of signalling networks? Check this wonderful review paper by Aneta Koseska @koseskalab.bsky.social & Philippe Bastiaens @jgojalvo.bsky.social @jordiplam.bsky.social www.embopress.org/doi/pdf/10.1...
Reposted by Philipp Niethammer
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 5:47 PM
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Philipp Niethammer
RIP James Watson. Reading The Double Helix in high school was one of the first times I felt the thrill of scientific discovery. But his later statements were also a stark reminder that great science and deeply flawed views can coexist in one person.
The obituary of someone who gained widespread fame through remarkable achievements at a young age and then expected to be taken seriously for anything he said thereafter.
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:54 PM
RIP James Watson. Reading The Double Helix in high school was one of the first times I felt the thrill of scientific discovery. But his later statements were also a stark reminder that great science and deeply flawed views can coexist in one person.
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
October 29, 2025 at 6:16 PM
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
Cool stuff!
Fazekas, Kaszás, Vámosi et al @enyedilab.bsky.social describe a #fibroblast-specific synthetic promoter that enables #biosensor expression & targeted ablation in #zebrafish fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns rupress.org/jcb/article/...
October 22, 2025 at 5:30 PM
Cool stuff!
Roosevelt Island, open air art ❣️
October 19, 2025 at 6:49 PM
Roosevelt Island, open air art ❣️
Daniel‘s lectures at our GSK Cancer Science Graduate School are always a curriculum highlight! Contemplating the implicit assumptions of modern biological science can foster new ways of thinking, as some of our old go-to concepts become unwieldy and show their limitations. Students loved it!
New Element in the Philosophy of Biology series—free to download until Oct. 24! @djnicholson.bsky.social uncovers Schrödinger’s motivations for writing "What Is Life?", revisits its central arguments & examines the book’s lasting impact on cell & molecular biology👇 www.cambridge.org/core/element...
October 18, 2025 at 1:02 PM
Daniel‘s lectures at our GSK Cancer Science Graduate School are always a curriculum highlight! Contemplating the implicit assumptions of modern biological science can foster new ways of thinking, as some of our old go-to concepts become unwieldy and show their limitations. Students loved it!
After some limbo, paper #1 finally accepted (i.p.). Watch out for a comprehensively updated version of pubmed.ncbi.nlm.nih.gov/39711539/.
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
October 3, 2025 at 7:35 PM
After some limbo, paper #1 finally accepted (i.p.). Watch out for a comprehensively updated version of pubmed.ncbi.nlm.nih.gov/39711539/.
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
October 2, 2025 at 4:39 PM
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
Reposted by Philipp Niethammer
Your reminder that many of the muscles, nerves and bones you use to hear and talk with correspond to gill structures in fish. 🧪 #evolution #paleontology
November 24, 2024 at 8:30 PM
Your reminder that many of the muscles, nerves and bones you use to hear and talk with correspond to gill structures in fish. 🧪 #evolution #paleontology
Moment of halt during my morning run: Our Four Freedoms veiled in strongman camo (Camouflage by Ai Weiwei, Roosevelt Island, NYC) - sober testament to civil society regression around the world and my complacency/compliance in witnessing it. fdrfourfreedomspark.org
September 27, 2025 at 2:07 PM
Moment of halt during my morning run: Our Four Freedoms veiled in strongman camo (Camouflage by Ai Weiwei, Roosevelt Island, NYC) - sober testament to civil society regression around the world and my complacency/compliance in witnessing it. fdrfourfreedomspark.org
Looking forward to www.phagocytes2026.com/programme
PROGRAMME | European Phagocyte Workshop 2026
www.phagocytes2026.com
September 16, 2025 at 12:47 PM
Looking forward to www.phagocytes2026.com/programme
First-in-class conceptual mRNAseq analysis - LCS v2.2 (Win) with updated stats, boxplots, alternative IPs, logical IP filtering, synthesizing experiments by Z-score integration, etc. Analyze your count-sheets and listen to cool 1990's D&B (-> LCS icons). Pls report bugs 🙏
github.com/niethamp/Log...
github.com/niethamp/Log...
Release LCS_Win_v2.2 · niethamp/LogicalClusteringSuiteWin
The Logical Clustering Suite (LCS) is a MATLAB-based application for the conceptual clustering of gene expression data. Instead of grouping genes by mutual similarity (as in hierarchical clustering...
github.com
September 9, 2025 at 12:58 AM
First-in-class conceptual mRNAseq analysis - LCS v2.2 (Win) with updated stats, boxplots, alternative IPs, logical IP filtering, synthesizing experiments by Z-score integration, etc. Analyze your count-sheets and listen to cool 1990's D&B (-> LCS icons). Pls report bugs 🙏
github.com/niethamp/Log...
github.com/niethamp/Log...
Reposted by Philipp Niethammer
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
August 29, 2025 at 10:37 PM
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
Reposted by Philipp Niethammer
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 8, 2025 at 3:06 PM
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Philipp Niethammer
"without my humanities leanings and studies, I would not have been a very good scientist. My humanities classes were a master class in creativity, envisioning new futures and how to think." bit.ly/4of8P8D
Opinion: Gutting humanities signals the end of innovation in business and STEM
Lose the humanities, and you lose the very ground of science and business that depend on it.
bit.ly
July 26, 2025 at 4:05 PM
"without my humanities leanings and studies, I would not have been a very good scientist. My humanities classes were a master class in creativity, envisioning new futures and how to think." bit.ly/4of8P8D
Reposted by Philipp Niethammer
Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here:
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
July 21, 2025 at 1:14 AM
Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here:
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
events.faseb.org/event/Mechan...
Opportunities for talks! Abstracts by Aug. 31st.
Reposted by Philipp Niethammer
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
July 16, 2025 at 6:35 PM
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Interesting preprint about nuclear membrane mechanotransduction in neutrophils!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
cPLA2α Targeting to Exosomes Connects Nuclear Deformation to LTB4-Signaling During Neutrophil Chemotaxis
Efficient neutrophil chemotaxis requires the integration of mechanical forces and lipid-mediated signaling. While the signaling lipid leukotriene B4 (LTB4) reinforces cellular polarity, how mechanical cues regulate its production remains unclear. We now show that cytosolic phospholipase A2α (cPLA₂α), which is essential for the synthesis of LTB4, functions as a nuclear curvosensor. cPLA₂α responds to nuclear constrictions by localizing to ceramide-rich inner nuclear membrane microdomains and incorporating onto the exofacial surface of nuclear envelope-derived exosomes. This unique topology enables localized LTB4 synthesis, which promotes myosin light chain II phosphorylation, and sustains polarity and directional persistence after constriction. In neutrophils squeezing through small constrictions, loss of cPLA₂α impairs nuclear curvature sensing, exosomal LTB4 production, and post-constriction motility. These findings uncover a cPLA2-dependent mechano-chemical axis linking nuclear architecture to chemotactic efficiency and offering new strategies to modulate inflammatory responses. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, EB030474, R01AI152517, GM145470 American Heart Association, https://ror.org/013kjyp64, 014194, 025905, 916874
www.biorxiv.org
July 8, 2025 at 1:20 PM
Interesting preprint about nuclear membrane mechanotransduction in neutrophils!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Philipp Niethammer
Researchers Train Mice To Choose Between Life-Saving Medications And Other Essentials theonion.com/researc...
July 2, 2025 at 2:00 PM
Researchers Train Mice To Choose Between Life-Saving Medications And Other Essentials theonion.com/researc...