Philipp Niethammer
@niethammerlab.bsky.social
Cell biologist interested in how tissues sense and adapt to physical and chemical stress. Wound healing and regeneration. Quantitative imaging approaches. Nuclear mechanotransduction, ROS signaling & metabolism. All opinions are my own.
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
October 29, 2025 at 6:16 PM
There was a parsing error in the sGEA module of v2.2 that affected the gene list outputs (not the stats). It is corrected now in v2.3. Sorry for the inconvenience.
github.com/niethamp/Log...
github.com/niethamp/Log...
Roosevelt Island, open air art ❣️
October 19, 2025 at 6:49 PM
Roosevelt Island, open air art ❣️
After some limbo, paper #1 finally accepted (i.p.). Watch out for a comprehensively updated version of pubmed.ncbi.nlm.nih.gov/39711539/.
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
October 3, 2025 at 7:35 PM
After some limbo, paper #1 finally accepted (i.p.). Watch out for a comprehensively updated version of pubmed.ncbi.nlm.nih.gov/39711539/.
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
October 2, 2025 at 4:39 PM
Looking forward to Florida, where my brilliant PhD student Zaza Gelashvili and I are giving back-to-back talks. Among other things, we'll talk about our work on www.biorxiv.org/content/10.1... www.researchsquare.com/article/rs-5..., which will hopefully come out soon in much improved versions!
Moment of halt during my morning run: Our Four Freedoms veiled in strongman camo (Camouflage by Ai Weiwei, Roosevelt Island, NYC) - sober testament to civil society regression around the world and my complacency/compliance in witnessing it. fdrfourfreedomspark.org
September 27, 2025 at 2:07 PM
Moment of halt during my morning run: Our Four Freedoms veiled in strongman camo (Camouflage by Ai Weiwei, Roosevelt Island, NYC) - sober testament to civil society regression around the world and my complacency/compliance in witnessing it. fdrfourfreedomspark.org
More than a century ago: Driesch’s mechanobiological interrogation of epigenesis. Biology today: still living of the conceptual substance those people provided, using fancier tools, adding finer and finer molecular detail, not usually more overall insight or imagination…life remains a mystery.
June 15, 2025 at 12:48 PM
More than a century ago: Driesch’s mechanobiological interrogation of epigenesis. Biology today: still living of the conceptual substance those people provided, using fancier tools, adding finer and finer molecular detail, not usually more overall insight or imagination…life remains a mystery.
When you mentees remember you in such a way, you have done something right. Could not have said it better.
June 3, 2025 at 2:03 PM
When you mentees remember you in such a way, you have done something right. Could not have said it better.
These were the times...
May 20, 2025 at 1:18 PM
These were the times...
May Day - asking for too much?
May 1, 2025 at 11:47 PM
May Day - asking for too much?
NYC does what we have to do!
April 19, 2025 at 4:49 PM
NYC does what we have to do!
Karl Jaspers was a smart man that went through dark times keeping his integrity.
April 9, 2025 at 2:25 AM
Karl Jaspers was a smart man that went through dark times keeping his integrity.
My son‘s expression when I explain my work in too much detail 🥱
April 6, 2025 at 1:01 PM
My son‘s expression when I explain my work in too much detail 🥱
Last pre-trade-war champagne🍾. In an heroic act of tinkering, Zaza revived our broken $800K confocal!!! Unfortunately, with 🤪 tariffs on champagne, we will need to resort to "Freedom Juice" (Soda-stream-carbonated, grape juice with 70% EtOH) for future events. Let the Golden Age begin!
March 31, 2025 at 9:36 PM
Last pre-trade-war champagne🍾. In an heroic act of tinkering, Zaza revived our broken $800K confocal!!! Unfortunately, with 🤪 tariffs on champagne, we will need to resort to "Freedom Juice" (Soda-stream-carbonated, grape juice with 70% EtOH) for future events. Let the Golden Age begin!
The 🌞is shining, the 🌬️ is rising and we
March 7, 2025 at 1:18 PM
The 🌞is shining, the 🌬️ is rising and we
March 7, Washington Square Park, NYC
March 3, 2025 at 11:55 PM
March 7, Washington Square Park, NYC
And not only for science…
March 3, 2025 at 11:48 AM
And not only for science…
If the pathway is really so important, why have so few researchers studied its physiological functions before? Answer: OXER1, like many other biomedically important genes, is not conserved in our main preclinical animal model, the mouse. But zebrafish have it!
www.eurekalert.org/news-release...
www.eurekalert.org/news-release...
February 10, 2025 at 7:15 PM
If the pathway is really so important, why have so few researchers studied its physiological functions before? Answer: OXER1, like many other biomedically important genes, is not conserved in our main preclinical animal model, the mouse. But zebrafish have it!
www.eurekalert.org/news-release...
www.eurekalert.org/news-release...
Miklos is currently testing if 5-KETE, through the mucoprotective mechanism he discovered, acts as a paracrine tumor suppressor. Interestingly, the 5-KETE receptor (OXER1) is inactivated by hotspot frameshift mutations in various mucosal tumors from patients (see below).
February 10, 2025 at 6:28 PM
Miklos is currently testing if 5-KETE, through the mucoprotective mechanism he discovered, acts as a paracrine tumor suppressor. Interestingly, the 5-KETE receptor (OXER1) is inactivated by hotspot frameshift mutations in various mucosal tumors from patients (see below).
Miklos then serendipitously discovered a surprising, non-immunological role for 5-KETE signaling (see 2nd preprint): It protects the gut mucosa against oxidative DNA lesions, apoptosis, leakage (see below images) and infection through inducing anti-mutagenic enzymes called "Nudix hydrolases" 🥂.
February 10, 2025 at 4:11 PM
Miklos then serendipitously discovered a surprising, non-immunological role for 5-KETE signaling (see 2nd preprint): It protects the gut mucosa against oxidative DNA lesions, apoptosis, leakage (see below images) and infection through inducing anti-mutagenic enzymes called "Nudix hydrolases" 🥂.