Nick DeVito
@ndevitomd.bsky.social
Assistant Prof, GI Oncologist @
Duke Cancer researching immunotherapy, metastasis, and the immune microenvironment.
#FirstGen. USouthFlorida alumnus. Tufts residency survivor.
Patients don’t fail treatments, treatments fail patients.
Opinions=mine
Duke Cancer researching immunotherapy, metastasis, and the immune microenvironment.
#FirstGen. USouthFlorida alumnus. Tufts residency survivor.
Patients don’t fail treatments, treatments fail patients.
Opinions=mine
Pinned
Nick DeVito
@ndevitomd.bsky.social
· Feb 24
Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling - PubMed
Therapeutic resistance to immune checkpoint blockade has been commonly linked to the process of mesenchymal transformation (MT) and remains a prevalent obstacle across many cancer types. An improved m...
pubmed.ncbi.nlm.nih.gov
After about 7 years of work and 9 months in review, our manuscript is finally PUBLISHED in Cancer Research!!!!
Here we describe tumor immune evasion during mesenchymal plasticity induced by the hedgehog transcription factor Gli2– time for a...bluetorial? skytorial?
pubmed.ncbi.nlm.nih.gov/39970333/
Here we describe tumor immune evasion during mesenchymal plasticity induced by the hedgehog transcription factor Gli2– time for a...bluetorial? skytorial?
pubmed.ncbi.nlm.nih.gov/39970333/
Reposted by Nick DeVito
Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance.
Here’s what to know about the new coalition.
Here’s what to know about the new coalition.
US Governors Launch Multistate Public Health Coalition
This Medical News article discusses a new state-led coalition, called the Governors Public Health Alliance, to bolster disease detection and response as federal support wanes.
jamanetwork.com
November 21, 2025 at 4:26 PM
Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance.
Here’s what to know about the new coalition.
Here’s what to know about the new coalition.
Reposted by Nick DeVito
#Review🚨
Spicer & team highlight our recent understanding of neutrophil extracellular traps #NETs biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.
📖 👇
Spicer & team highlight our recent understanding of neutrophil extracellular traps #NETs biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.
📖 👇
Neutrophil extracellular traps in cancer - Nature Reviews Cancer
Neutrophil extracellular traps (NETs) influence cancer initiation, progression and metastasis through immunosuppressive mechanisms within the tumour microenvironment. In this Review, Shahzad et al. highlight our recent understanding of NET biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.
bit.ly
November 19, 2025 at 3:12 PM
Reposted by Nick DeVito
A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪
November 19, 2025 at 2:17 PM
A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪
Reposted by Nick DeVito
Reposted by Nick DeVito
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
November 16, 2025 at 2:00 PM
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Reposted by Nick DeVito
Great.
"Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics."
www.ft.com/content/23e9...
"Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics."
www.ft.com/content/23e9...
The irresistible rise of libertarian eugenics
Social Darwinism is making a comeback in the US — this time wrapped in the language of freedom
www.ft.com
November 16, 2025 at 10:01 AM
Great.
"Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics."
www.ft.com/content/23e9...
"Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics."
www.ft.com/content/23e9...
Way to call out these thieves, perfect line.
Open AI loses copyright case in Germany.
Judge Elke Schwager summarized the case saying that if you want to build something and need components, "then you purchase them and do not use the property of others."
Judge Elke Schwager summarized the case saying that if you want to build something and need components, "then you purchase them and do not use the property of others."
Blow for OpenAI in Germany as court rules song lyrics used illegally
A German court ruled on Tuesday that OpenAI violated copyright on nine popular songs in a lawsuit that marked another attempt to prevent the free use of artists' content online. The Munich Regional Co...
www.yahoo.com
November 15, 2025 at 1:42 AM
Way to call out these thieves, perfect line.
My overview of MSI-H colorectal cancer management post ASCO and ESMO, aka “the ATOMIC diss track,” is up on VuMedi:
www.vumedi.com/video/manage...
www.vumedi.com/video/manage...
Management of MSI-H CRC Including New Data From ESMO 2025
A video from Nicholas Devito (as part of Duke Cancer Institute), posted on Oct 31, 2025.
www.vumedi.com
November 10, 2025 at 9:59 PM
My overview of MSI-H colorectal cancer management post ASCO and ESMO, aka “the ATOMIC diss track,” is up on VuMedi:
www.vumedi.com/video/manage...
www.vumedi.com/video/manage...
Reposted by Nick DeVito
Next week LinkedIn will use your personal data for AI training by automatically enabling permissions.
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
November 2, 2025 at 5:07 AM
Next week LinkedIn will use your personal data for AI training by automatically enabling permissions.
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
Reposted by Nick DeVito
Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home
September 29, 2025 at 1:38 PM
Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home
Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 3:22 PM
Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too
Reposted by Nick DeVito
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 25, 2025 at 1:42 PM
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
YAP is a tough drug target with implications in resistance to immunotherapy and other treatments, these are some very encouraging results
www.nature.com/articles/s41...
www.nature.com/articles/s41...
YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial - Nature Medicine
As presented at the European Society for Medical Oncology Congress 2025: In patients with locally advanced or metastatic solid tumours, including mesothelioma, treatment with a first-in-class inhibito...
www.nature.com
October 20, 2025 at 2:09 PM
YAP is a tough drug target with implications in resistance to immunotherapy and other treatments, these are some very encouraging results
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The tumor immunology and immunotherapy lecture "Know the System Know the Drug,” that Dan Schrum and I recorded for trainees, is up on YouTube!
If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk.
m.youtube.com/watch?v=atiS...
If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk.
m.youtube.com/watch?v=atiS...
Immunology for Oncology Fellows Faculty and Pharmacy Residents
YouTube video by DukeCancerInstitute
m.youtube.com
October 18, 2025 at 9:58 AM
The tumor immunology and immunotherapy lecture "Know the System Know the Drug,” that Dan Schrum and I recorded for trainees, is up on YouTube!
If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk.
m.youtube.com/watch?v=atiS...
If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk.
m.youtube.com/watch?v=atiS...
Reposted by Nick DeVito
No words
May 30, 2025 at 12:23 PM
No words
Reposted by Nick DeVito
Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression https://www.medrxiv.org/content/10.1101/2025.10.06.25337175v1
October 7, 2025 at 10:28 PM
Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression https://www.medrxiv.org/content/10.1101/2025.10.06.25337175v1
Lactate impairs TLS formation - nice pre print www.biorxiv.org/content/10.1...
Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis
Tertiary lymphoid structures (TLS) and B cell infiltration are strong predictors of immunotherapy success across cancers, including triple-negative breast cancer (TNBC). However, immune-cold TNBCs oft...
www.biorxiv.org
October 7, 2025 at 4:39 PM
Lactate impairs TLS formation - nice pre print www.biorxiv.org/content/10.1...
Reposted by Nick DeVito
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
“Chris wasn’t even 10 and government funding was already working toward his cure. So, what are we risking in 30 years by cutting NIH funding?
…that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”
…that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”
One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹
Former NCI official’s nonprofit seeks to tell the stories of cancer patients
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
October 5, 2025 at 12:54 PM
“Chris wasn’t even 10 and government funding was already working toward his cure. So, what are we risking in 30 years by cutting NIH funding?
…that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”
…that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”
Reposted by Nick DeVito
One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹
Former NCI official’s nonprofit seeks to tell the stories of cancer patients
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Former NCI official’s nonprofit seeks to tell the stories of cancer patients Patient Action for Cancer Research aims to show impact of federal research - The Cancer Letter
Chris Biggar, a 34-year-old from Ohio, had just landed his dream job working in R&D when he was diagnosed with stage 4 colon cancer. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled […]
cancerletter.com
October 3, 2025 at 11:54 PM
One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹
Reposted by Nick DeVito
It’s the difference between life & death.
The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy.
They are lying to you. With fatal consequences. While making money.
3/
The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy.
They are lying to you. With fatal consequences. While making money.
3/
October 5, 2025 at 12:15 AM
It’s the difference between life & death.
The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy.
They are lying to you. With fatal consequences. While making money.
3/
The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy.
They are lying to you. With fatal consequences. While making money.
3/
One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹
Former NCI official’s nonprofit seeks to tell the stories of cancer patients
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Former NCI official’s nonprofit seeks to tell the stories of cancer patients Patient Action for Cancer Research aims to show impact of federal research - The Cancer Letter
Chris Biggar, a 34-year-old from Ohio, had just landed his dream job working in R&D when he was diagnosed with stage 4 colon cancer. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled […]
cancerletter.com
October 3, 2025 at 11:54 PM
One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹
Reposted by Nick DeVito
Former NCI official’s nonprofit seeks to tell the stories of cancer patients
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Former NCI official’s nonprofit seeks to tell the stories of cancer patients Patient Action for Cancer Research aims to show impact of federal research - The Cancer Letter
Chris Biggar, a 34-year-old from Ohio, had just landed his dream job working in R&D when he was diagnosed with stage 4 colon cancer. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled […]
cancerletter.com
October 3, 2025 at 9:05 PM
Former NCI official’s nonprofit seeks to tell the stories of cancer patients
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Patient Action for Cancer Research aims to show impact of federal research
https://cancerletter.com/the-cancer-letter/20251003_1/
Reposted by Nick DeVito
Early-onset gastrointestinal cancer is currently the most rapidly increasing early-onset cancer in the US.
This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures.
ja.ma/46BERoo
This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures.
ja.ma/46BERoo
October 3, 2025 at 11:00 AM
Early-onset gastrointestinal cancer is currently the most rapidly increasing early-onset cancer in the US.
This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures.
ja.ma/46BERoo
This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures.
ja.ma/46BERoo