Lightnews — Scholar-powered news

Reposted by Féaron Cassidy, PhD

Ele Willoughby @minouette.bsky.social · 3d

For day 12 of #spacetober_challenge prompt eclipse: #mathematician & #astronomer Nicole-Reine Lepaute (1723-1788) and her calculated path of the solar eclipse of 1764. 🧪🐡👩🏼‍🔬🧮🔭 #histsci She also worked with Alexis Clairaut & Jérôme Lalande to precisely calculate the date of return of Halley’s Comet, 🧵

My linocut print of mathematician & astronomer Nicole-Reine Lepaute (1723-1788) in a vertical gradient (bottom to top) of bright pink to lavender on white paper. She wears a wig and gown and the portrait is from the chest to head. Her 12 diagrams of the phases of the annular the solar eclipse of 1764 as viewed from Paris appear across her shoulders. Behind her head in green is her map of the path of the eclipse across Europe.

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BK. Titanji @boghuma.bsky.social · 1d

Awesome public health news:
Maldives becomes the first country to achieve ‘triple elimination’ of
1. mother-to-child transmission of HIV,
2. Syphilis and
3. Hepatitis B
www.who.int/news/item/13...

Maldives becomes the first country to achieve ‘triple elimination’ of mother-to-child transmission of HIV, syphilis and hepatitis B

In a landmark public health achievement, WHO has validated the Maldives for eliminating mother-to-child transmission (EMTCT) of hepatitis B, while maintaining its earlier validation (in 2019) for EMTCT of HIV and syphilis. This makes the Maldives the first country in the world to achieve ‘triple elimination’.

www.who.int

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Pam Ronald @pcronald.bsky.social · 1d

Remarkable recovery of the Klamath River salmon. Many thanks to the agencies, Tribes, and NGOs who came together to remove dams and monitor the recovery of the Klamath River salmon. And kudos, too, to the indigenous youth who paddled source to sea on the newly freed river

Colorful kayaks in a circle on the water

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Emily Moin @emilymoin.com · 4d

I am open to the idea that there are people who don't have and don't want to gain the skills to engage directly with their data but every single day that I do I learn the answer to a question you'd never even think to ask unless you were personally staring into the abyss of an uncleaned dataset.

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Suzanne Hoppins @shoppins.bsky.social · 4d

Genuinely thrilled to share our new story with the world - an amazing collaboration with @profsharona.bsky.social and Bill Zagotta using their innovative FRET technique to study mitofusin conformational changes. Huge credit to Sophie Hurwitz for tackling this project. urldefense.com/v3/__https:/...

Structural insights into GTP-coupled conformational changes in Mfn1 revealed by time-resolved transition metal ion FRET.

Outer mitochondrial membrane fusion is mediated by the mitofusin paralogs Mfn1 and Mfn2. Nucleotide-driven self-assembly and conformational changes are required for regulated membrane fusion activity,...

urldefense.com

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Reposted by Féaron Cassidy, PhD

Marion Pepper @marionpepper.bsky.social · 4d

Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells

Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

www.biorxiv.org

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The Conversation UK @uk.theconversation.com · 4d

The Venezuelan opposition leader was forced to go into hiding in 2024 after being banned form standing in that year’s election.

Nobel peace prize winner Maria Corina Machado: Venezuelan opposition leader forced into hiding after taking on Maduro

The Venezuelan opposition leader was forced to go into hiding in 2024 after being banned form standing in that year’s election.

tcnv.link

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Madhu Pai, MD, PhD @madhupai.bsky.social · 4d

Immigrant scientists make a massive contribution wherever they go

More than 30% of this century’s science Nobel prizewinners immigrated

www.nature.com/articles/d41...

More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

www.nature.com

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Drug Monkey @drugmonkey.bsky.social · 5d

"We're doing the studies to make the proof."

This is not how Gold Standard Science works. Or any science. You do the study to TEST THE HYPOTHESIS, not to prove yourself right.

Aaron Rupar @atrupar.com · 5d

RFK Jr on Tylenol and autism: "It is not proof. We're doing the studies to make the proof."

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Kate Cavanaugh @katecavanaugh.bsky.social · 13d

Implantation is inherently a mechanical process. We find contractility is necessary and sufficient for spreading behaviors. We can artificially age embryos from young females and even rescue aged embryo spreading just by tuning contractility!

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Colette Delawalla @cdelawalla.bsky.social · 13d

THIS IS THE WAY.

Everyone gets their knickers in a twist when I say we can’t sci-comm our way out of this mess…but maybe you’ll listen to the more eloquent and measured @edyong209.bsky.social!

This isn’t happening because people don’t appreciate the brilliance of the double helix structure.

Science Vs @sciencevs.bsky.social · 13d

This moment from our latest episode with science writer @edyong209.bsky.social is 🔥

We asked Ed — how do we talk up the benefits of science in the face of government cuts? He told us that's the wrong approach. 🧪

Listen wherever, or watch on Spotify 👇

open.spotify.com/episode/7Evh...

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 13d

The remarkable number of people, me included, who were inspired by her work, life and example is the biggest tribute. Find a way to honor her memory. The wolrd is a bit smaller and sadder with her gone

The Guardian @theguardian.com · 13d

Jane Goodall, world-renowned primatologist, dies aged 91

Jane Goodall Institute says ‘tireless advocate’ for natural world died in California during US speaking tour The world-renowned primatologist Jane Goodall has died at the age of 91, her institute has said. The Jane Goodall Institute announced that she had passed away of natural causes while in California as part of a US speaking tour. Continue reading...

www.theguardian.com

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Alanna Smith @alannawrites.bsky.social · 13d

The language of non-consent around AI is really telling. "It's too late to be scared." "It's here whether we want it or not." "You'll have to learn to work with it." "You can't fight the inevitable."

All just variations of "you're not allowed to say no." Creepy technology made by creepy people.

The Guardian @theguardian.com · 14d

‘It’s too late to be scared’: readers on the controversial rise of AI ‘actors’

The birth of AI ‘actor’ Tilly Norwood has caused a backlash in Hollywood and has sparked conversation from Guardian readers

www.theguardian.com

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ryan cooper @ryanlcooper.com · 14d

"In 2012, 60 trans-related articles were published by Britain’s media. By 2022, it was more than 7,500, according to figures from Trans Media Watch. The media is not responding to public rage against vulnerable minorities; it is helping to create it." www.prospectmagazine.co.uk/politics/709...

What is a reactionary centrist, and does the UK have them?

A term favoured by US progressives can help us understand Britain’s drift to the right

www.prospectmagazine.co.uk

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Franklin_LAB @franklinlab.bsky.social · 14d

Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.

www.biorxiv.org/content/10.1...

NLRP3 is a thermosensor that is negatively regulated by high temperature

Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...

www.biorxiv.org

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Ming Tommy Tang @tommytang.bsky.social · 14d

Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data www.nature.com/articles/s4...

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Jim Dickinson @jimdickinson.bsky.social · 14d

"Almost 200 Cardiff University staff members left in limbo as they face losing jobs | Wales Online"

Almost 200 Cardiff University staff members left in limbo as they face losing jobs | Wales Online

Cardiff University confirmed it cannot rule out compulsory redundancies as it also apologised to students for problems with a new timetabling system as the academic year begins

bit.ly

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Reposted by Féaron Cassidy, PhD

Open Research and Public Engagement Roadmap @engagedroadmap.bsky.social · 14d

This journey working on ENGAGED Open Research and Public Engagement Roadmap has been a privilege, but in many ways the work is only just beginning. With the data and insights from our workshops, we can now start shaping the roadmap in a meaningful way. #openresearch #publicengagement

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Sara Wickstrom @sarawickstrom.bsky.social · 15d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Amy Diehl, Ph.D. @amydiehl.bsky.social · 14d

Women aren’t just blamed for everything, they’re conditioned to accept it. Poverty, crime (single moms), rape (short skirts, drinking), incels (women not dating unappealing men), divorce (women file the majority of cases) & anything w/ pregnancy & children. www.thenation.com/article/soci...

Targeting Tylenol Is Just Another Excuse to Blame Women for Everything

It's a longstanding tradition to blame all manner of social ills on women, without any basis in fact.

www.thenation.com

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Ming Tommy Tang @tommytang.bsky.social · 25d

Nature methods: Cancer subclone detection based on DNA copy number in single-cell and spatial omic sequencing data www.nature.com/articles/s4...

Cancer subclone detection based on DNA copy number in single-cell and spatial omic sequencing data

Nature Methods - Clonalscope is a method for cancer subclone detection leveraging copy number profiles estimated using spatial and single-cell sequencing data.

www.nature.com

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Maik Bischoff @maikbischoff.bsky.social · 21d

1/12 A very special moment for me! 🎉

My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.

rupress.org/jcb/article/...

#cellbio #devbio #science

🧵for details

Cartoon of a speculative heterogenous cell population performing mesenchymal collective cell migration.

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Nature Metabolism @natmetabolism.nature.com · 20d

✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪

www.nature.com/natmetab/vol...

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Ming Tommy Tang @tommytang.bsky.social · 19d

Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer www.nature.com/articles/s4...

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BF Francis Ouellette @bffo.bsky.social · 19d

From @cellpress.bsky.social #Genomics | Galaxy #single-cell & spatial omics community update: Navigating new frontiers in 2025 | #Bioinformatics #Genomics #OpenScience #OpenSource #Perspective #UseGalaxy 🧬 🖥️ 🧪 🔓
⬇️
www.cell.com/cell-genomic...

Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025

The Galaxy single-cell and spatial omics community (SPOC) brings together over 175 tools, 120+ training resources, and a global user community in a unified FAIR platform. By integrating leading suites...

www.cell.com

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