Devan Sinha
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devsinha.bsky.social
Devan Sinha
@devsinha.bsky.social
Neuroradiologist | Molecular Medicine | into science and data | via Oxford Med
Reposted by Devan Sinha
The Crick is paying £800,000 in visa fees alone. Britain is choosing to turn inwards, away from the world, and to destroy its own future. That is not Britain. observer.co.uk/news/politic...
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
May 11, 2025 at 8:02 AM
Reposted by Devan Sinha
I can’t believe we have to explain the difference between transgenic and transgender mice
March 5, 2025 at 3:49 PM
Reposted by Devan Sinha
The inevitable cost. Not only people eventually dying of HIV-associated diseases, but that along the way there will be a massive explosion in antiretroviral drug resistance as some of those living with HIV skip doses to help out friends.
In South Africa, Samkelo shared his last HIV/AIDS medications with his friend. Trump's cuts to #PEPFAR could kill both of them. A salute to the @financialtimes.com for this searing report. @brandonwolf.bsky.social @gregggonsalves.bsky.social @ambdanfoote.bsky.social www.ft.com/content/533b...
February 27, 2025 at 6:57 PM
Or as the @telegraphnews.bsky.social editorial staff prefer to call it - the 'Roman" salute 😱
"US billionaire Elon Musk appeared to make a Heil Hitler salute at the Washington DC Trump parade on Monday, following Trump's inauguration. Musk was seen making the gesture a total of three times on live television"
(Jerusalem Post)
www.jpost.com/internationa...
Did Elon Musk appear to Sieg Heil at Trump inauguration?
Musk was seen making the gesture a total of three times on live television.
www.jpost.com
January 20, 2025 at 9:21 PM
I think the RoK National Assembly just voted to end martial law by majority of 190-0... As per auto translate and live Korean TV.

Everything is fine 🙂
Martial law is being covered live by South Korea's television networks. This is the live feed, now from the National Assembly in Seoul from MBC. Beware the Washington "Korea experts" on American TV - they know nothing & are the biggest supporters of the dictator Yoon. www.youtube.com/watch?v=lg75...
[속보] 긴박한 국회.. 이재명 "민주주의 보루, 국회 지켜달라" 한동훈 "국회에서 즉시 계엄 해제 요구할 것" - [MBC뉴스특보] 2024.12.03
YouTube video by MBCNEWS
www.youtube.com
December 3, 2024 at 4:09 PM
Reposted by Devan Sinha
“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.”
www.researchamerica.org/2023-oped-us...
Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019.
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
Long a ‘Crown Jewel’ of Government, N.I.H. Is Now a Target
nytimes.com
December 1, 2024 at 11:58 PM
Reposted by Devan Sinha
New article by me & Lucas at Our World in Data!

The COVID-19 pandemic is estimated to have killed more than 25 million people; it caused grief & suffering among their loved ones, impacted people's health worldwide & disrupted work & lifestyles.

We look back on the pandemic with 17 charts:
17 key charts to understand the COVID-19 pandemic
The pandemic has resulted in over twenty million deaths. In this article, we review the key insights from global data on COVID-19.
ourworldindata.org
November 18, 2024 at 10:21 AM
China similarly found statistically significant rise in Situs Inversus births during C19 surge.

Absolute risk of congenital heart defect etc remains v low.

Hypothetically would fit proven SARS-CoV-2 in vivo cilia dysfunction. Cilia being crucial in L-R embryology patterning and cardiac folding.
Huge cohort

A total of 11,010,764 births before & 7,060,626 births during the pandemic were analysed.

The number of births with a congenital heart condition increased from 56.5 per 100k births pre pandemic to 65.4 per 100k births after pandemic year 1 - a 16% increase.
Huge study of 18 million births from US found the proportion of babies born with a congenital heart abnormality increased by 16% after the first year of the Covid pandemic.

Study: obgyn.onlinelibrary.wiley.com/doi/10.1002/...

www.news-medical.net/news/2024111...
November 18, 2024 at 9:54 AM
Reposted by Devan Sinha
Keep seeing references to UK food security.
Since the mid-19th century UK food security has meant the ability to keep the sea lanes open and imports flowing in. Not the ability to produce domestic needs at home.
November 18, 2024 at 9:32 AM
Last year thought SGLT2 inhibitors would be the revolutionary HFpEF med of our time.

SUMMIT Trial of Tirzepatide (dual GIP/GLP1-R agonist) just demonstrated a greater effect size in reducing risk of death from cardiovascular causes or worsening Heart Failure 🔻 38%.
👀

www.nejm.org/doi/full/10....
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
www.nejm.org
November 17, 2024 at 9:28 PM
Reposted by Devan Sinha
“Since 1974, vaccination has averted 154 million deaths, including 146 million among children younger than 5 years of whom 101 million were infants younger than 1 year.” #IDSky

www.thelancet.com/journals/lan...
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...
www.thelancet.com
November 15, 2024 at 2:47 PM
Reposted by Devan Sinha
Worst Trump cabinet nominee so far?

1️⃣ <a href="https://poll.blue/p/JFhoaV/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">RFK Jr - Health
2️⃣ <a href="https://poll.blue/p/JFhoaV/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Tulsi Gabbard - Director of National Intelligence
3️⃣ <a href="https://poll.blue/p/JFhoaV/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Pete Hegseth - Defense
4️⃣ <a href="https://poll.blue/p/JFhoaV/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Matt Gaetz - Attorney General

📊 Show results
November 14, 2024 at 10:42 PM
A stupendous 93% reduction in 3-yr diabetes incidence risk.

0.07 Hazard ratio for diabetes of Tirzepatide (dual GIP/GLP1-R agonist) in patients with obesity.

Drug effects of this magnitude outside of preventative ID vaccines are absolutely wild.

www.nejm.org/doi/full/10....
November 15, 2024 at 9:33 AM
So much sense and clear thinking about trial design and public interventions.

Especially in an emergent disease setting.
Why we should stop looking for an NPI miracle - new post on underpowered trials and future disease threats: kucharski.substack.com/p/stop-looki...
November 15, 2024 at 9:20 AM
Reposted by Devan Sinha
Good day to remind everyone

Around the globe the measles vaccine has saved nearly 94 million lives over the past 50 years

www.scientificamerican.com/article/see-...
November 14, 2024 at 9:55 PM
Worst Trump cabinet nominee so far?

1️⃣ <a href="https://poll.blue/p/JFhoaV/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">RFK Jr - Health
2️⃣ <a href="https://poll.blue/p/JFhoaV/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Tulsi Gabbard - Director of National Intelligence
3️⃣ <a href="https://poll.blue/p/JFhoaV/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Pete Hegseth - Defense
4️⃣ <a href="https://poll.blue/p/JFhoaV/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Matt Gaetz - Attorney General

📊 Show results
November 14, 2024 at 10:42 PM
Reposted by Devan Sinha
The emails and text messages flying around and among my NIH peeps in response to RFK Jr. is craaaazy.

I’m so disappointed and disgusted.

Am feeling like I might have dodged a bullet in not getting selected as NEI SD.

Feeling for my NIH peeps now and worried about biomedical research in America.
November 14, 2024 at 9:51 PM
The guy who caught brain worms (Neurocysticercosis) from handling a bear carcass.

The guy whose virulent propagation of anti-vax conspiracies during a measles outbreak contributed to 83 deaths (mostly children) in American Samoa.
NEW: RFK is Trump’s nominee for Health Secretary.

Buckle up.
November 14, 2024 at 9:36 PM
133 new users per second...
...meanwhile at Bluesky HQ
November 14, 2024 at 5:42 PM
Completely unacceptable from GMC

Why shld doctors be held accountable to our respective specialist medical Royal College standards when GMC, who want to equally register PAs, say they shld not bound to that same standard specified in 'GMC good medical practice'?
www.pulsetoday.co.uk/news/regulat...
November 14, 2024 at 5:16 PM
Hi Everyone :)

Having created the account ages ago thought I'd finally enter the discourse. Critical mass, intrigue, civility are all here!

One thing I wish I'd known earlier - 📌 for bookmarking - so many great links and papers to catch up on!
November 14, 2024 at 8:23 AM
Reposted by Devan Sinha
💉 JCVI statement advising on COVID-19 vaccination in spring 2025, autumn 2025 & spring 2026. #IDsky #EpiSky

🔗 JCVI statement: www.gov.uk/government/p...

📄 Referenced modelling preprint "Cost-effectiveness of routine COVID-19 adult vaccination programmes in England":
www.medrxiv.org/content/10.1...
November 13, 2024 at 11:34 PM
Reposted by Devan Sinha
This is why John Mulaney's "Horse in a Hospital" bit is still the best stand-up about Trump.
Remember now? This is how it felt every day for FOUR YEARS. Every fucking day never knowing if he was going to buy Greenland, sell Alaska to Putin, invite Kim Jong Un to party or fire the FBI director and appoint some guy he saw on TV. That feeling? Get used to it again.
November 13, 2024 at 8:59 PM