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Andrea Manca

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H-index: 40
Economics 62%
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Reposted by Andrea Manca, Robert Böhm, Brendan Nyhan , and 15 more

jamiecummins.bsky.social
Can large language models stand in for human participants?
Many social scientists seem to think so, and are already using "silicon samples" in research.

One problem: depending on the analytic decisions made, you can basically get these samples to show any effect you want.

THREAD 🧵
The threat of analytic flexibility in using large language models to simulate human data: A call to attention
Social scientists are now using large language models to create "silicon samples" - synthetic datasets intended to stand in for human respondents, aimed at revolutionising human subjects research. How...
arxiv.org
12 150 330

by Andrea Manca

amancayork.bsky.social
Just 2 weeks to go to our residential course on advanced statistical methods in economic evaluation for HTA which will be held in beautiful city of York.
amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jul 12
Do you want to expand your professional competence in HTA? Register to attend the Statistical Methods in Economic Evaluation for HTA - Advanced Course at the University of York🚀 ⁦‪⁦‪@CHEyork‬⁩

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk
1

Reposted by Andrea Manca, David Cutler, Anirban Basu , and 1 more

johnmullahy.bsky.social
Ten years have elapsed since Will Manning left us.

Early career health economists not familiar with Will and his work might benefit from knowing the significant and enduring contributions Will made to our field.

onlinelibrary.wiley.com/doi/10.1002/...
1 9 29

by Andrea Manca

amancayork.bsky.social
Do you want to expand your professional competence in HTA? Register to attend the Statistical Methods in Economic Evaluation for HTA - Advanced Course at the University of York🚀 ⁦‪⁦‪@CHEyork‬⁩

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk
1

by Andrea Manca — Reposted by Andrea Manca, Torbjørn Wisløff

amancayork.bsky.social
Please share with your network.

3-day Advanced Course on Statistical Methods in Economic Evaluation for HTA: Advanced Course: September 9-11, 2025!

Now with an updated program including modern methods for causal inference and machine learning.

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk
2 4

Reposted by Andrea Manca

lruggiero.bsky.social
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
www.science.org/content/arti...
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
www.science.org
2

by Marion Campbell — Reposted by Andrea Manca, Amanda Farrin, Marion Campbell

marionkcampbell.bsky.social
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
1 9 15

by Andrea Manca — Reposted by Torbjørn Wisløff

amancayork.bsky.social
@CHEyork @UoY_BizTraining @UniOfYork short courses are run face to face in beautiful York, where you’ll be able to meet and spend time interacting with our faculty of experts as well as network with other participants from the industry, consultancy and academia
www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk
2

by Andrea Manca

amancayork.bsky.social
Correct link: www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

by Andrea Manca

amancayork.bsky.social
📊Unlock the power of data!📊

Join the Statistical Methods in Economic Evaluation for HTA - Advanced short course at the University of York🚀

📅 9-11 September 2025
📍 York, UK

Secure your spot today! 🔗 york.ac.uk/che/courses/st…#DataSciencece#HealthEconomicsc#HTAT#CEAEA
https://york.ac.uk/che/courses/st…
1 1

by Andrea Manca

amancayork.bsky.social
This work is the result of research collaboration between the Universities of York and Sheffield.
1

by Andrea Manca

amancayork.bsky.social
and another one my colleagues recently presented a report to the German parliament on pharmaceutical pricing.

www.york.ac.uk/che/news/nil...
Professor Nils Gutacker presents report on pharmaceutical pricing to German parliament
Recommendations for fair pricing of innovative products
www.york.ac.uk

by Andrea Manca

amancayork.bsky.social
Another piece of research asked “How much should the NHS pay for new drugs when they are used to treat more than one condition?” eepru.sites.sheffield.ac.uk/eepru2-proje...
Pricing models for multi-indication drugs in the UK NHS
Pricing models for multi-indication drugs in the UK NHS
eepru.sites.sheffield.ac.uk
2 2

by Andrea Manca

amancayork.bsky.social
One of these answer the question “how should we reward pharmaceutical innovation?” www.york.ac.uk/media/che/Ho...
www.york.ac.uk
1 1

by Andrea Manca

amancayork.bsky.social
interesting article by
@investigate-europe.eu on the price of drugs in the EU, heterogeneity of access across countries and how to negotiate with Pharma www.europeanpressprize.com/article/dead.... Colleagues in York have made important scientific contributions to inform possible negotiations.
Deadly Prices - How Big Pharma Feeds Inequality in Europe - European Press Prize
She is only three years old, but the process is as routine as if she had done it thousands of times before. On this far too warm spring day, Milda, a little girl with a short ponytail, puts on the pin...
www.europeanpressprize.com
1 2

Reposted by Andrea Manca

ai.nejm.org
This article analyzes how nonexperts perceive AI-generated medical advice, finding that it is often rated as accurate as — or better than — doctor responses, raising concerns about overreliance and potential harm from incorrect guidance. Full article: nejm.ai/43xKDG0

#AI #MedSky #MLSky
People Overtrust AI-Generated Medical Advice despite Low Accuracy
This article presents a comprehensive analysis of how artificial intelligence (AI)–generated medical responses are perceived and evaluated by nonexperts. We conducted a study in which a total of 30...
nejm.ai
7 10

by Andrea Manca

amancayork.bsky.social
Delighted to offer our residential 3-day course on Statistical Methods in Economic Evaluation for HTA: Advanced Course: September 9-11, 2025!

Now with an updated program including modern methods for causal inference and machine learning.

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

Reposted by Andrea Manca

aarontay.bsky.social
[Read] LLM-based relevance assessment still can’t replace
human relevance assessment arxiv.org/pdf/2412.17156. Really interesting paper, challenging the recent idea that one can use LLLM-based relevance assessments to replace human judgements as gold standard,
1 7 20

by Andrea Manca

amancayork.bsky.social
We are looking to recruit two Research Fellows - Grade 6/7, to work within the Economic Evaluation and Health Technology Assessment team within CHE. Closing Date - 27th April 2025. For further details, visit jobs.york.ac.uk/vacancy/rese...
Jobs - The University of York
jobs.york.ac.uk
1 1

by Andrea Manca

amancayork.bsky.social
'York would be a different city without Rowntree' www.bbc.com/news/article...
How chocolate entrepreneur's values shaped York
Joseph Rowntree's legacy lives on in city where his factory was, 100 years after his death.
www.bbc.com

by Eric J. Topol — Reposted by Andrea Manca

erictopol.bsky.social
New example of opportunistic A.I. in medicine
Get a liver diagnosis from an echocardiogram
ai.nejm.org/doi/full/10....
@cedarssinai.bsky.social @ai.nejm.org
Opportunistic Screening of Chronic Liver Disease with Deep-Learning–Enhanced Echocardiography
Chronic liver disease (CLD) affects more than 1.5 billion adults, most of whom are asymptomatic and undiagnosed. Echocardiography is broadly performed and visualizes the liver, but this information...
ai.nejm.org
2 20 75

Reposted by Andrea Manca

“Why don’t machine learning and large language model evaluations report uncertainty?”
statmodeling.stat.columbia.edu/2025/02/22/w...
“Why don’t machine learning and large language model evaluations report uncertainty?” | Statistical Modeling, Causal Inference, and Social Science
statmodeling.stat.columbia.edu
2 1 19

by Andrea Manca — Reposted by Andrea Manca

amancayork.bsky.social
Delighted to offer our residential 3-day course on Statistical Methods in Economic Evaluation for Health Technology Assessment: Advanced Course: September 9-11, 2025!

Discover more at: lnkd.in/eY6UCP_W

Now with an updated program including modern methods for causal inference and machine learning.
HealthEconomics.com | A Scientist.com Company on LinkedIn: The Centre for Health Economics University of York is delighted to offer…
The Centre for Health Economics University of York is delighted to offer its residential 3-day short course on Statistical Methods in Economic Evaluation for…
www.linkedin.com
1

by Andrea Manca — Reposted by Andrea Manca

amancayork.bsky.social
Evaluation of Medical Devices for Product Development and Health Technology Assessment Course

Date - 7th-9th October 2025
Course Leader - Dr Cynthia Iglesias

You can find further details of the course on the University of York website: bit.ly/41lx4cb
Centre for Health Economics on LinkedIn: 📚 Evaluation of Medical Devices for Product Development and Health…
📚 Evaluation of Medical Devices for Product Development and Health Technology Assessment Course Date - 7th-9th October 2025 Course Leader - Dr Cynthia…
www.linkedin.com
2 3

Reposted by Andrea Manca

p-hunermund.com
This is a great paper by Mitsuru Igami framing breakthrough AI algorithms in the familiar logic of structural economic model estimation. doi.org/10.1093/ectj...

But by implication, if structural models behave like board games, such as Chess and Go, how high can their degree of realism really be?
4 3 9

by Eric J. Topol — Reposted by Andrea Manca, Mariacristina De Nardi

erictopol.bsky.social
Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
www.nature.com
5 76 280

by Martin McKee — Reposted by Andrea Manca, Kent Buse, Heidi Stöckl

martinmckee.bsky.social
To our many American friends. The National Academies have assembled a package of resources for researchers facing threats or attacks in the US

www.nationalacademies.org/chr/resource...
www.nationalacademies.org
14 290 450

by John Drury — Reposted by Andrea Manca

profjohndrury.bsky.social
'In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.'

www.nature.com/articles/d41...
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.
www.nature.com
6 42 57

by Andrea Manca

amancayork.bsky.social
jamanetwork.com/journals/jam...
Evidence Lacking for Many AI Tools Used in Primary Care
This Medical News article is an interview with study author María Villalobos-Quesada, PhD, a researcher at the National eHealth Living Lab at the Leiden University Medical Centre in the Netherlands.
jamanetwork.com

Reposted by Andrea Manca

madhupai.bsky.social
Designing effective training programs for applied mathematical modeling

speakingofmedicine.plos.org/2025/01/14/d...
Designing effective training programs for applied mathematical modeling
Applied modeling is a highly cross-disciplinary field, requiring a unique mixture of hard skills, soft skills, and domain knowledge. Successful training programs are those that include hands-on simult...
speakingofmedicine.plos.org
5 13

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