Scientific Reports - Lactate/albumin ratio predicts mortality in critically ill COVID-19 patients: a retrospective machine learning study

Publication date: Available online 17 October 2025 Source: Experimental Eye Research Author(s): Yong Yu, Yu Di, Peijie Li, Qingzhu Nie, Xiaolong Chen, Aiyuan Wang, Kaiming Ren

Adaptation to cellular stresses entails an incompletely understood coordination of transcriptional and post-transcriptional gene expression programs. Here, by quantifying hypoxia-dependent transcriptomes, epigenomes and translatomes in T47D breast cancer cells and H9 human embryonic stem cells, we show pervasive changes in transcription start site (TSS) selection associated with nucleosome repositioning and alterations in H3K4me3 distribution. Notably, hypoxia-associated TSS switching was induced or reversed via pharmacological modulation of H3K4me3 in the absence of hypoxia, defining a role for H3K4me3 in TSS selection independent of HIF1-transcriptional programs. By remodelling 5′UTRs, TSS switching selectively alters protein synthesis, including enhanced translation of messenger RNAs encoding pyruvate dehydrogenase kinase 1, which is essential for metabolic adaptation to hypoxia. These results demonstrate a previously unappreciated mechanism of translational regulation during hypoxi

In this paper, we present a novel hypothesis as to what led humans in the Upper Paleolithic to penetrate and decorate deep, dark caves.

A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with a consideration of the po...

Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.

A Mississippi man convicted of rape and murder was put to death by lethal injection, the third execution in the United States this week.

Climate change affects water quality by increasing land and water temperatures and intensifying extreme weather events. Using over 2.2 million water q…