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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
12K followers 510 following 3.6K posts
Respiratory and Sleep Medicine Neurobiology and Long Cövid WHN Long Covid Working Group Vice Chair
Posts Media Videos Starter Packs
davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 1d
Diabetics and COVID.

Not great for your 🫀

www.frontiersin.org/journals/pha...
Frontiers | Diabetic cardiomyopathy and COVID-19: intersecting pathways and amplified cardiovascular risk
Diabetic cardiomyopathy (DCM) is a diabetes-induced heart condition characterized by ventricular dysfunction without other cardiac diseases. Chronic hypergly...
www.frontiersin.org
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2d
More Bad JuJu for kids and Cøvid.

Cardiovascular health is something we should explore. Dyslipidaemia and endothelial injury aren't isolated to adults!

journals.lww.com/hhmi/fulltex...
journals.lww.com
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2d
🧠 Daily Feed of Brain Damage 🧠

👇🏻👇🏻👇🏻

www.nature.com/articles/s44...
COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years - npj Dementia
npj Dementia - COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years
www.nature.com
1 34 86
davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2d
Sorted

doi.org/10.1038/s414...
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner - Nature Communications
Whether paternal pre-conceptual SARS-CoV-2 infection impacts sperm RNA content, or effects offspring phenotypes, has not been previously investigated. Here authors report changes in sperm noncoding RNAs in SARS-CoV-2 infected sires and increased anxiety-like behaviors in offspring.
doi.org
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2d
doi.org/10.1038/s414...
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2d
🧠 Daily Feed of Brain Damage 🧠

Unborn Edition

nature.com/articles/s4146…
https://nature.com/articles/s4146…
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 3d
BULLSHIT ‼️🙏🏻
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 3d
Crap 🙏🏻
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 3d
February 2020
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 3d
Influenza versus Cövid.

826 COVID vs 89 flu deaths, and within 90 days, 1,391 COVID vs 149 flu deaths, showing worse outcomes for COVID-19

Rough maths? About 10 times more fatal

journals.plos.org/plosmedicine...
Comparative risk of post-acute sequelae among adults following SARS-CoV-2 or influenza virus infection: A retrospective cohort study among United States adults
Author summary Why was this study done? It is known that people may suffer medical complications long after COVID-19, which are called post-acute sequelae (PAS). Similar sequelae are also known to h...
journals.plos.org
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 3d
The cost of doing nothing☠️‼️

@binitakane.bsky.social 🙏🏻

jamanetwork.com/journals/jam...
Enduring Outcomes of COVID-19 Work Absences on the US Labor Market
This cohort study examines the extent to which COVID-19 continues to generate work absences and decrease labor force participation beyond the pandemic period in the US.
jamanetwork.com
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Reposted by Dr David Joffe MB BS(Hons), PhD, FRACP
meownersclub.bsky.social
Eleanor Fielding @meownersclub.bsky.social · 4d
#ME #Disability #Psychiatry #Biopsychosocial
@meassociation.org.uk
@longcovidsupport.bsky.social
@thelancet.com
@nhsengland.bsky.social
@georgemonbiot.bsky.social
@profstevegriffin.bsky.social
@davidjoffe64.bsky.social
@drjoepajak.bsky.social
Title - This Week in Disbelief.. This is a cartoon in 3 vertical sections - Section 1 title - "The Most Hated Doctor in Britain" has been appointed by a Labour government as vice-chair of an investigation into whether mental health problems and neurodivergence are being OVERDIAGNOSED. Section 2 title - Prof Simon Wessely, the careerist punitive psychiatrist whose views on #MEcfs have led to decades of underfunding, medical ignorance. unnecessary disability and definitely preventable deaths. seems wedded to these powerful persecutory roles. Section 3 title - How can we understand this commitment to coercion from a doctor? Does he perhaps: • Crave recognition from powerful groups? • Struggle with unresolved trauma? • Chase career and social gains? • Lack self-awareness & empathy? • Think the ends justify the means? In the bottom right hand corner is wise Cat who’s saying “Or perhaps he's just a dick?!” The cartoon maker is #FanningTheFlames
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 4d
A normal Lymphocyte differential is just numbers...

It tells you nothing about function‼️

www.frontiersin.org/journals/cel...
Frontiers | Persistent lymphocytopenia in convalescent patients with COVID-19: dysregulated B cell, CD4+ T cell, and treg compartments in 7–12% of moderate-severe cases
BackgroundLong COVID manifests with heterogeneous clinical outcomes, potentially linked to immune dysfunction. However, the recovery of immune-cell subsets d...
www.frontiersin.org
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Reposted by Dr David Joffe MB BS(Hons), PhD, FRACP
meownersclub.bsky.social
Eleanor Fielding @meownersclub.bsky.social · 4d
#ME #Disability #Psychiatry #Biopsychosocial
@meassociation.org.uk
@longcovidsupport.bsky.social
@thelancet.com
@nhsengland.bsky.social
@georgemonbiot.bsky.social
@profstevegriffin.bsky.social
@davidjoffe64.bsky.social
@drjoepajak.bsky.social
Title - This Week in Disbelief.. This is a cartoon in 3 vertical sections - Section 1 title - "The Most Hated Doctor in Britain" has been appointed by a Labour government as vice-chair of an investigation into whether mental health problems and neurodivergence are being OVERDIAGNOSED. Section 2 title - Prof Simon Wessely, the careerist punitive psychiatrist whose views on #MEcfs have led to decades of underfunding, medical ignorance. unnecessary disability and definitely preventable deaths. seems wedded to these powerful persecutory roles. Section 3 title - How can we understand this commitment to coercion from a doctor? Does he perhaps: • Crave recognition from powerful groups? • Struggle with unresolved trauma? • Chase career and social gains? • Lack self-awareness & empathy? • Think the ends justify the means? In the bottom right hand corner is wise Cat who’s saying “Or perhaps he's just a dick?!” The cartoon maker is #FanningTheFlames
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 5d
More Opthalmic complications of Cøvid. Vaccinations reduce the risk.

www.nature.com/articles/s41...
Ophthalmic complications associated with COVID-19: a large US national database analysis - Eye
Eye - Ophthalmic complications associated with COVID-19: a large US national database analysis
www.nature.com
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 5d
More Bad JuJu for the unborn 😔

www.nature.com/articles/s41...
SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability - Cell Death & Disease
Cell Death & Disease - SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability
www.nature.com
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 5d
That's a more complex question, Paul.

Myocarditis is common in MISC. The heart is rich in vessels. My assumption is it can happen acutely, or at an increased risk after the MISC has been treated. This hypothesis is based on the likely persistence of inflammation.
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 5d
MISC can occur with the first O et subsequent infections...

You don't get to choose
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 5d
www.mdpi.com/2077-0383/14...
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 6d
Pregnancy and C-19 are NOT good friends 🤬‼️

www.nature.com/articles/s41...
SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability - Cell Death & Disease
Cell Death & Disease - SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability
www.nature.com
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 8d
That's exactly why we have pushed back against GET and CBT for Long C-19.

Fine for mere mortals....

.... Poison for Long C-19 ☠️
kianopoly.bsky.social
kianopoly.bsky.social @kianopoly.bsky.social · 8d
@davidjoffe64.bsky.social these studies are saying the exact opposite and might confuse people :((( www.lboro.ac.uk/news-events/...
Exercise could promote recovery following COVID-19, study finds
New research has found that exercise can help restore the immune system after COVID-19, easing symptoms such as fatigue, joint pain, and other long-term effects.
www.lboro.ac.uk
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 9d
😮😮
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 9d
I'm completely without words!!

Professor Hotez named me in his acknowledgements 😳😳

My Goodness... I'm just a Lung and Sleep Dude🤦🏻‍♂️

What an awesome honour😊🙏🏻
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 9d
Arrived today 👏🏻👏🏻‼️

Looking forward to reading it!

In the darkest hours... There are still amazing humans 💖
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davidjoffe64.bsky.social
Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 10d
I would suggest the evidence for MECSF isn't strong. The viral/environmental triggers are many and not often identifed.

COVID? The evidence for pathways of altered gene expression are plentiful. P53 and many involved in the hosts immune response to infection.
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