🚀Tools are here:
🦠Engineered Bifidobacterium consortia!
💊Dual IDO1/TDO inhibitors!
⌛Chrono-dosing strategies!
Together, they form synergistic “smart #Protocols” that adapt in real-time using “Saliva, #Plasma & “#Stool #Metabolomics! @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...
🦠Engineered Bifidobacterium consortia!
💊Dual IDO1/TDO inhibitors!
⌛Chrono-dosing strategies!
Together, they form synergistic “smart #Protocols” that adapt in real-time using “Saliva, #Plasma & “#Stool #Metabolomics! @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...
October 29, 2025 at 6:28 AM
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🧬 Molecule of the Moment: #mRNA4359 + #pembrolizumab
At #ESMO2025, #Moderna reported early Phase 1/2 data showing mRNA-4359 may overcome checkpoint inhibitor–resistant #melanoma by targeting #PDL1 & #IDO1 pathways. Combo with pembrolizumab showed manageable safety, no new immune AEs.
At #ESMO2025, #Moderna reported early Phase 1/2 data showing mRNA-4359 may overcome checkpoint inhibitor–resistant #melanoma by targeting #PDL1 & #IDO1 pathways. Combo with pembrolizumab showed manageable safety, no new immune AEs.
October 22, 2025 at 6:20 AM
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Colon cancer reprograms tryptophan metabolism to augment VTE risk in mice, which is mitigated by an IDO1 inhibitor. Read in Blood Advances: buff.ly/SjLY4mI
October 17, 2025 at 12:44 PM
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journals.plos.org/plospathogen...
"study identifies IDO1 production as a key cell-autonomous defense mechanism that limits infection by C. burnetii, which suggests that peptides derived from hydrolysis of proteins in the CCV do not provide an adequate supply of tryptophan for bacterial replication"
"study identifies IDO1 production as a key cell-autonomous defense mechanism that limits infection by C. burnetii, which suggests that peptides derived from hydrolysis of proteins in the CCV do not provide an adequate supply of tryptophan for bacterial replication"
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
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journals.plos.org/plospathogen...
"Using differentiated THP1 macrophage-like cells it was determined that IFNγ-activation resulted in IDO1 production, and that supplementation of IFNγ-activated THP1 cells with tryptophan enhanced C. burnetii replication."
"Using differentiated THP1 macrophage-like cells it was determined that IFNγ-activation resulted in IDO1 production, and that supplementation of IFNγ-activated THP1 cells with tryptophan enhanced C. burnetii replication."
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
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journals.plos.org/plospathogen...
"Additionally, ectopic expression of IDO1 in host cells was sufficient to restrict replication of C. burnetii in the absence of IFNγ signaling."
"Additionally, ectopic expression of IDO1 in host cells was sufficient to restrict replication of C. burnetii in the absence of IFNγ signaling."
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
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journals.plos.org/plospathogen...
"Cells deficient in IDO1 function were more permissive for C. burnetii replication when treated with IFNγ, and supplementing IFNγ-treated cells with tryptophan enhanced intracellular replication."
"Cells deficient in IDO1 function were more permissive for C. burnetii replication when treated with IFNγ, and supplementing IFNγ-treated cells with tryptophan enhanced intracellular replication."
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
Everybody can reply
journals.plos.org/plospathogen...
"IDO1 is an enzyme that catabolizes cellular tryptophan to kynurenine metabolites thereby reducing tryptophan availability in cells."
"IDO1 is an enzyme that catabolizes cellular tryptophan to kynurenine metabolites thereby reducing tryptophan availability in cells."
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
Everybody can reply
journals.plos.org/plospathogen...
"This screen demonstrated that Indoleamine 2,3-dioxygenase 1 ( #IDO1) contributes to IFNγ-mediated restriction of C. burnetii."
"This screen demonstrated that Indoleamine 2,3-dioxygenase 1 ( #IDO1) contributes to IFNγ-mediated restriction of C. burnetii."
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
Everybody can reply
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 ( #IDO1) inhibits lysosomal replication of Coxiella burnetii #MECFS #LongCovid
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...
journals.plos.org
October 16, 2025 at 12:06 PM
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In @jem.org, Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...
October 15, 2025 at 6:30 PM
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Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...
October 15, 2025 at 5:00 PM
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Immune Checkpoint Molecule Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Expressed in Lymphoma Subtypes With and Without Epstein-Barr Virus
journals.lww.com/appliedimmun...
journals.lww.com/appliedimmun...
journals.lww.com
October 1, 2025 at 12:49 AM
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Just out: Ligand-induced conformations and dynamic allosteric motions of IDO1 affecting the recruitment of a protein signaling partner
Ligand-induced conformations and dynamic allosteric motions of IDO1 affecting the recruitment of a protein signaling partner
Communications Chemistry, Published online: 24 September 2025; doi:10.1038/s42004-025-01648-2Indoleamine 2,3-dioxygenase 1 (IDO1) is crucial in cancer-related immunosuppression, yet its signaling function remains underexplored in immunotherapy development. Here, the authors use second harmonic generation analysis and molecular dynamics simulations to reveal that clinical IDO1 inhibitors differentially modulate its signaling, impacting distinct transcriptomes.
bit.ly
September 24, 2025 at 11:15 PM
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'(...) subpar responses following Francisella tularensis infection were associated with the inability of T cells to readily proliferate upon re-challenge (...) these features were partially a consequence of IFN-γ driven reprogramming of endothelial cells resulting in expression of IDO1'
#Immunology
#Immunology
Non-hematopoietic tryptophan metabolism is a driver of ineffective T cell responses during secondary pulmonary bacterial infection
Abstract. Pulmonary infections often fail to produce long-lived immune memory and the underlying mechanism(s) for this are unclear. Given the complex inter
academic.oup.com
September 16, 2025 at 3:44 PM
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Your brain's neurons aren't dying in Alzheimer's - they're STARVING 🧠
Stanford achieves COMPLETE memory restoration in AD models
Neurons aren't dying, they're starving due to IDO1 hijacking metabolism.
Block IDO1 = restored memory. Completely.
The drugs already exist.
youtube.com/shorts/jqVYd...
Stanford achieves COMPLETE memory restoration in AD models
Neurons aren't dying, they're starving due to IDO1 hijacking metabolism.
Block IDO1 = restored memory. Completely.
The drugs already exist.
youtube.com/shorts/jqVYd...
Memory COMPLETELY Restored in Alzheimer's Models
YouTube video by Dr. Kevin Tran
youtube.com
September 15, 2025 at 8:52 PM
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8/ Action steps TODAY:
✓ Get a sleep study (75% chance you need it)
✓ Monitor sleep quality religiously
✓ Watch for IDO1 inhibitor trials
✓ Don't wait for symptoms
Complete analysis: youtu.be/T5E2F92tYvU
✓ Get a sleep study (75% chance you need it)
✓ Monitor sleep quality religiously
✓ Watch for IDO1 inhibitor trials
✓ Don't wait for symptoms
Complete analysis: youtu.be/T5E2F92tYvU
Scientists Find New Way to Stop Memory Loss! APOE4 carriers pay attention!
YouTube video by Dr. Kevin Tran
youtu.be
September 12, 2025 at 5:26 PM
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6/ Here's the convergence:
IDO1 inhibitors? Already passed safety trials
CPAP for OSA? Protective against cognitive decline
DORAs? FDA-approved + reduce tau phosphorylation
The treatments EXIST
IDO1 inhibitors? Already passed safety trials
CPAP for OSA? Protective against cognitive decline
DORAs? FDA-approved + reduce tau phosphorylation
The treatments EXIST
September 12, 2025 at 5:26 PM
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3/ When they blocked IDO1 in AD models:
✓ Complete restoration of spatial memory
✓ Normalized brain metabolism
✓ Worked for BOTH amyloid and tau
✓ Human AD cells showed same response
"Complete restoration to normal levels"
✓ Complete restoration of spatial memory
✓ Normalized brain metabolism
✓ Worked for BOTH amyloid and tau
✓ Human AD cells showed same response
"Complete restoration to normal levels"
September 12, 2025 at 5:26 PM
Everybody can reply
Dr. Andreasson discovered neurons aren't dying - they're STARVING
The IDO1 enzyme hijacks a critical metabolic switch, shutting down the brain's glucose-to-lactate conversion
Neurons lose their primary fuel source
The IDO1 enzyme hijacks a critical metabolic switch, shutting down the brain's glucose-to-lactate conversion
Neurons lose their primary fuel source
September 12, 2025 at 5:26 PM
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Pesquisadores da Universidade do Texas em Arlington identificaram duas enzimas, IDO1 e NOS, que afetam o metabolismo do colesterol durante a inflamação. Ao bloqueá-las, foi possível...
Matéria completa - regisandrade.com.br/cientistas-p...
#ciência #saúde #colesterol #descoberta #inovação #doenças
Matéria completa - regisandrade.com.br/cientistas-p...
#ciência #saúde #colesterol #descoberta #inovação #doenças
September 2, 2025 at 12:04 AM
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New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @mpibiochem.bsky.social our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial proteomics reveals mechanisms of cell-intrinsic tryptophan metabolism controlling ovarian cancer survival
Indole-2,3-dioxygenase (IDO1) depletes tryptophan to dampen anti‑tumor T cells, yet IDO1 inhibitors (IDO1i) have failed clinically. Using deep visual proteomics, we isolated IDO1 high, medium and low ...
www.biorxiv.org
August 20, 2025 at 5:15 AM
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University of Texas pinpointed a potential way to stop some of the deadliest modern diseases before they even start enzyme IDO1 that disrupts how immune cells called macrophages handle cholesterol during inflammation linked to heart disease, diabetes www.sciencedaily.com/releases/202...
August 16, 2025 at 11:48 AM
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Proteome and secretome profiling of the melanoma-induced transition towards immune incompetent dendritic cells reveals enhanced IDO1, cathepsin, and legumain activity #MCP #MassSpec www.mcponline.org/article/S153...
Proteome and secretome profiling of the melanoma-induced transition towards immune incompetent dendritic cells reveals enhanced IDO1, cathepsin, and legumain activity
Dendritic cells (DCs) are professional antigen-presenting cells endowed with the capacity
to initiate strong antitumor immune responses. This function is critical for effective
DC-based immunotherapie...
www.mcponline.org
August 10, 2025 at 6:22 AM
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Compelling Day 4 Plenary at #AAIC25 from Prof Katrin Andreasson of @stanfordpress.bsky.social showing "tremendous potential" for repurposing IDO1 inhibitors, trialled in cancer, for delaying progression in MCI and #AlzheimersDisease #dementiaresearch
July 30, 2025 at 6:23 PM
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