Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
In @jhumimmunity.org, Moratti et al. exemplify how an effective management of IEI-related LPD demands close collaboration among immunologists, hematologists, and pathologists. rupress.org/jhi/article-...
February 13, 2026 at 6:30 PM
In @jhumimmunity.org, Moratti et al. exemplify how an effective management of IEI-related LPD demands close collaboration among immunologists, hematologists, and pathologists. rupress.org/jhi/article-...
New @jhumimmunity.org Editorial: @petterbrodin.bsky.social, @macattacklab.bsky.social, @casanovalab.bsky.social, alongside JHI's Associate, Consulting, as well as Society Editors, outline a broader scope for the journal.
Expanding the scope of human immunology in the Journal of Human Immunity
A broader scope for the Journal of Human Immunity.
rupress.org
February 13, 2026 at 5:45 PM
New @jhumimmunity.org Editorial: @petterbrodin.bsky.social, @macattacklab.bsky.social, @casanovalab.bsky.social, alongside JHI's Associate, Consulting, as well as Society Editors, outline a broader scope for the journal.
#InMemoriam @jcb.org: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...
February 13, 2026 at 5:00 PM
#InMemoriam @jcb.org: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...
In @jgp.org, McGuinness, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
February 12, 2026 at 6:00 PM
In @jgp.org, McGuinness, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
In @jcb.org, Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
#CellSignaling #Cytoskeleton #Development
February 12, 2026 at 5:00 PM
In @jcb.org, Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
#CellSignaling #Cytoskeleton #Development
In @jcb.org Spotlight, Pacheco and @drericabiophd.bsky.social discuss new study from @mayorlab.bsky.social (rupress.org/jcb/article/...) which reveals the distinct force-generating mechanisms used by epithelial and mesenchymal cells during collective cell migration rupress.org/jcb/article/...
February 11, 2026 at 7:01 PM
In @jcb.org Spotlight, Pacheco and @drericabiophd.bsky.social discuss new study from @mayorlab.bsky.social (rupress.org/jcb/article/...) which reveals the distinct force-generating mechanisms used by epithelial and mesenchymal cells during collective cell migration rupress.org/jcb/article/...
Latest in @jgp.org Research News: a recent JGP study from Antonella Dapino and Sebastián Curti (rupress.org/jgp/article/...) reveals that the D-type K⁺ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. rupress.org/jgp/article/...
February 11, 2026 at 6:30 PM
Latest in @jgp.org Research News: a recent JGP study from Antonella Dapino and Sebastián Curti (rupress.org/jgp/article/...) reveals that the D-type K⁺ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. rupress.org/jgp/article/...
In a new opinion article @jem.org, Silva-Santos, @rafaelblancodom.bsky.social et al. @gimminstitute.bsky.social discuss the potential of Vδ1⁺ γδ T cells for #cancer #immunotherapy, focusing on delta one T (DOT) cells. rupress.org/jem/article/...
#FoundInTranslation #TumorImmunology
#FoundInTranslation #TumorImmunology
February 11, 2026 at 5:45 PM
In a new opinion article @jem.org, Silva-Santos, @rafaelblancodom.bsky.social et al. @gimminstitute.bsky.social discuss the potential of Vδ1⁺ γδ T cells for #cancer #immunotherapy, focusing on delta one T (DOT) cells. rupress.org/jem/article/...
#FoundInTranslation #TumorImmunology
#FoundInTranslation #TumorImmunology
Spotlight @jcb.org: Ball and Röper @pdncambridge.bsky.social discuss recent findings by Almasoud, Franz et al. (rupress.org/jcb/article/...) describing how apical–basal polarity regulates cell–cell adhesion in the #Drosophila fat body rupress.org/jcb/article/...
#Adhesion #Cytoskeleton #Development
#Adhesion #Cytoskeleton #Development
February 11, 2026 at 5:00 PM
Spotlight @jcb.org: Ball and Röper @pdncambridge.bsky.social discuss recent findings by Almasoud, Franz et al. (rupress.org/jcb/article/...) describing how apical–basal polarity regulates cell–cell adhesion in the #Drosophila fat body rupress.org/jcb/article/...
#Adhesion #Cytoskeleton #Development
#Adhesion #Cytoskeleton #Development
Nasal vaccination aims to generate protection from pathogens. In @jem.org, Liu, Stoler-Barak & @zivshulman.bsky.social demonstrate that B cells in the nasal lymph nodes depend on BCR affinity & CCR6 for positioning in the NALT subepithelial dome and class switching to IgA rupress.org/jem/article/...
February 10, 2026 at 6:45 PM
Nasal vaccination aims to generate protection from pathogens. In @jem.org, Liu, Stoler-Barak & @zivshulman.bsky.social demonstrate that B cells in the nasal lymph nodes depend on BCR affinity & CCR6 for positioning in the NALT subepithelial dome and class switching to IgA rupress.org/jem/article/...
In @jhumimmunity.org, Akalu et al. @bogunoviclab.bsky.social report new and long-term follow-up cases of human #TBK1 deficiency, revealing that, beyond systemic #autoinflammation, affected individuals are also vulnerable to severe viral #encephalitis. rupress.org/jhi/article/...
Human TBK1 deficiency: An expanded spectrum from autoinflammation to viral encephalitis
Akalu et al. report new and long-term follow-up cases of human TBK1 deficiency, revealing that, beyond systemic autoinflammation, affected individuals are
rupress.org
February 10, 2026 at 6:30 PM
In @jhumimmunity.org, Akalu et al. @bogunoviclab.bsky.social report new and long-term follow-up cases of human #TBK1 deficiency, revealing that, beyond systemic #autoinflammation, affected individuals are also vulnerable to severe viral #encephalitis. rupress.org/jhi/article/...
In @jgp.org: Using a prepulse protocol on insect Caᵥ4 calcium channel, Cens, Charnet et al. report a current facilitation restricted to the descending branch of the I–V curve. Facilitation was less pronounced when a loop III-IV inactivation motif was mutated rupress.org/jgp/article/...
February 10, 2026 at 5:45 PM
In @jgp.org: Using a prepulse protocol on insect Caᵥ4 calcium channel, Cens, Charnet et al. report a current facilitation restricted to the descending branch of the I–V curve. Facilitation was less pronounced when a loop III-IV inactivation motif was mutated rupress.org/jgp/article/...
In @jem.org, @ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
February 10, 2026 at 5:00 PM
In @jem.org, @ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
A recent JEM @jem.org study from Aroca-Crevillén, @drusqui.bsky.social et al. (rupress.org/jem/article/...) may provide a novel clue into the connection between neutrophils and the severity of daytime heart attacks. More in @jama.com: jamanetwork.com/journals/jama/fullarticle/2844961
February 9, 2026 at 3:30 PM
A recent JEM @jem.org study from Aroca-Crevillén, @drusqui.bsky.social et al. (rupress.org/jem/article/...) may provide a novel clue into the connection between neutrophils and the severity of daytime heart attacks. More in @jama.com: jamanetwork.com/journals/jama/fullarticle/2844961
In @jhumimmunity.org, Guarnieri, Elfeky et al. @greatormondst.bsky.social report long-term outcomes after #HSCT in children with chronic granulomatous disease. While survival is excellent, a wide range of autoimmune and organ-specific late effects emerge. rupress.org/jhi/article/...
#CGD
#CGD
February 6, 2026 at 6:30 PM
In @jhumimmunity.org, Guarnieri, Elfeky et al. @greatormondst.bsky.social report long-term outcomes after #HSCT in children with chronic granulomatous disease. While survival is excellent, a wide range of autoimmune and organ-specific late effects emerge. rupress.org/jhi/article/...
#CGD
#CGD
New work @jgp.org from Palloni, DiFrancesco et al. shows that AMPK inhibits HCN4 membrane expression by direct channel phosphorylation, and shows that this process contributes to age-dependent intrinsic cardiac rate slowing. rupress.org/jgp/article/...
February 6, 2026 at 6:01 PM
New work @jgp.org from Palloni, DiFrancesco et al. shows that AMPK inhibits HCN4 membrane expression by direct channel phosphorylation, and shows that this process contributes to age-dependent intrinsic cardiac rate slowing. rupress.org/jgp/article/...
In @jem.org, Birui Pan, Chen Dong et al. identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. rupress.org/jem/article/...
February 6, 2026 at 5:30 PM
In @jem.org, Birui Pan, Chen Dong et al. identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. rupress.org/jem/article/...
In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
February 6, 2026 at 5:00 PM
In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
In @jhumimmunity.org, Duintjer, Blom et al. @unileiden.bsky.social present clinical follow-up data of 6.5 years of #NewbornScreening for #SCID, underscoring the importance of preventing overtreatment and avoiding unnecessary prolonged follow-up. rupress.org/jhi/article/...
#Immunodeficiencies
#Immunodeficiencies
February 5, 2026 at 5:15 PM
In @jhumimmunity.org, Duintjer, Blom et al. @unileiden.bsky.social present clinical follow-up data of 6.5 years of #NewbornScreening for #SCID, underscoring the importance of preventing overtreatment and avoiding unnecessary prolonged follow-up. rupress.org/jhi/article/...
#Immunodeficiencies
#Immunodeficiencies
In @jhumimmunity.org, Takeuchi, Okada et al. report that hemorrhage detected on imaging may predict poor outcomes in acute necrotizing encephalopathy associated w/ #COVID19 and that RANBP2 mutations could contribute to disease susceptibility. rupress.org/jhi/article/...
#InfectiousDiseases #SarsCoV2
#InfectiousDiseases #SarsCoV2
February 4, 2026 at 5:00 PM
In @jhumimmunity.org, Takeuchi, Okada et al. report that hemorrhage detected on imaging may predict poor outcomes in acute necrotizing encephalopathy associated w/ #COVID19 and that RANBP2 mutations could contribute to disease susceptibility. rupress.org/jhi/article/...
#InfectiousDiseases #SarsCoV2
#InfectiousDiseases #SarsCoV2
In @jcb.org, Ambrosio, Di Pietro et al. discover GRIPAP1 is a component of the cellular machinery that produces the #platelet α-granule, a member of the #lysosome-related organelle family. rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking
#Biochemistry #Disease #Organelles #Trafficking
February 3, 2026 at 8:15 PM
In @jcb.org, Ambrosio, Di Pietro et al. discover GRIPAP1 is a component of the cellular machinery that produces the #platelet α-granule, a member of the #lysosome-related organelle family. rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking
#Biochemistry #Disease #Organelles #Trafficking
In @jcb.org, Zych, Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
February 3, 2026 at 7:45 PM
In @jcb.org, Zych, Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
In @jcb.org, Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #lipid #ER_literature #LipidDroplets
#Organelles #Virology #lipid #ER_literature #LipidDroplets
February 3, 2026 at 7:01 PM
In @jcb.org, Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #lipid #ER_literature #LipidDroplets
#Organelles #Virology #lipid #ER_literature #LipidDroplets
In @jcb.org, Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle
#Chromatin #epigenetics #Genetics #CellCycle
February 3, 2026 at 6:45 PM
In @jcb.org, Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle
#Chromatin #epigenetics #Genetics #CellCycle
@jem.org's February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
February 2, 2026 at 3:15 PM
@jem.org's February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)