Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
In @jem.org, Gervais et al show that, in 149 int'l fulminant viral hepatitis patients, auto-Abs neutralizing type I interferons are found in 37.5% of HSV-triggered cases & are absent in hepatitis A & B virus–triggered cases, increasing the risk of HSV-FVH by >1,800-fold rupress.org/jem/article/...
December 5, 2025 at 7:00 PM
In @jem.org, Gervais et al show that, in 149 int'l fulminant viral hepatitis patients, auto-Abs neutralizing type I interferons are found in 37.5% of HSV-triggered cases & are absent in hepatitis A & B virus–triggered cases, increasing the risk of HSV-FVH by >1,800-fold rupress.org/jem/article/...
In @jem.org, Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/...
(1/2) 🧵 👇
(1/2) 🧵 👇
December 5, 2025 at 6:45 PM
In @jem.org, Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/...
(1/2) 🧵 👇
(1/2) 🧵 👇
In @jem.org, Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 5, 2025 at 6:30 PM
In @jem.org, Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social identified peptide sequence principles that drive dendritic cell maturation and broaden tumor-reactive T cell clones, even with non-tumor sequences. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
In @jhumimmunity.org, Martins-Ferreira and @eballestar.bsky.social review how ICF syndrome serves as a paradigm of epigenetic #immunodeficiency. They show how alterations in DNA methylation and chromatin remodeling disrupt genome stability and B cell maturation. rupress.org/jhi/article/...
December 5, 2025 at 6:01 PM
In @jhumimmunity.org, Martins-Ferreira and @eballestar.bsky.social review how ICF syndrome serves as a paradigm of epigenetic #immunodeficiency. They show how alterations in DNA methylation and chromatin remodeling disrupt genome stability and B cell maturation. rupress.org/jhi/article/...
In @jem.org, Rhodehouse, Siliciano @jhu.edu and colleagues characterize a nonhuman primate model of natural control of SIV infection in which the immune system blocks new infection events with an efficiency approaching that of antiretroviral therapy. rupress.org/jem/article/...
#Virology
#Virology
December 5, 2025 at 5:30 PM
In @jem.org, Rhodehouse, Siliciano @jhu.edu and colleagues characterize a nonhuman primate model of natural control of SIV infection in which the immune system blocks new infection events with an efficiency approaching that of antiretroviral therapy. rupress.org/jem/article/...
#Virology
#Virology
In @jcb.org, Ferby et al. show that ErbB3 regulates Integrin β1 recycling in breast epithelial cells independently of ligand signaling. Its loss redirects cargo to extracellular vesicles, impairs migration, & reveals a novel role for pseudo-RTKs in vesicular trafficking. rupress.org/jcb/article/...
December 5, 2025 at 5:00 PM
In @jcb.org, Ferby et al. show that ErbB3 regulates Integrin β1 recycling in breast epithelial cells independently of ligand signaling. Its loss redirects cargo to extracellular vesicles, impairs migration, & reveals a novel role for pseudo-RTKs in vesicular trafficking. rupress.org/jcb/article/...
📣 Help choose @jcb.org's cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wednesday, December 31 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025 #ScienceArt
#CellBio2025 #ScienceArt
December 5, 2025 at 4:15 PM
📣 Help choose @jcb.org's cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wednesday, December 31 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025 #ScienceArt
#CellBio2025 #ScienceArt
In @jem.org, Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology
#Hematopoiesis #LymphocyteBiology
December 4, 2025 at 5:00 PM
In @jem.org, Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology
#Hematopoiesis #LymphocyteBiology
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
December 3, 2025 at 8:15 PM
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
December 3, 2025 at 7:45 PM
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
December 3, 2025 at 7:15 PM
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
December 3, 2025 at 6:45 PM
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
December 3, 2025 at 6:15 PM
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
December 3, 2025 at 5:45 PM
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
Reposted by Rockefeller University Press
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wed. December 31. Don’t miss your chance to have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025
#CellBio2025
December 3, 2025 at 4:30 PM
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wed. December 31. Don’t miss your chance to have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025
#CellBio2025
Reposted by Rockefeller University Press
Attending #CellBio2025 this weekend and interested in discussing your research with JCB editors? Our editorial team will be available:
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
December 3, 2025 at 4:02 PM
Attending #CellBio2025 this weekend and interested in discussing your research with JCB editors? Our editorial team will be available:
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
December 3, 2025 at 5:15 PM
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
Reposted by Rockefeller University Press
Attending #CellBio2025 this weekend? Be sure to visit us at Journal of Cell Biology Booth #1224 to chat about the journal, pick up a copy of The Year in Cell Biology: 2025 magazine 📕, and grab one of our exclusive puzzles 🧩
See our annual collection: rupress.org/jcb/collecti...
See our annual collection: rupress.org/jcb/collecti...
December 3, 2025 at 3:45 PM
Attending #CellBio2025 this weekend? Be sure to visit us at Journal of Cell Biology Booth #1224 to chat about the journal, pick up a copy of The Year in Cell Biology: 2025 magazine 📕, and grab one of our exclusive puzzles 🧩
See our annual collection: rupress.org/jcb/collecti...
See our annual collection: rupress.org/jcb/collecti...
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
December 3, 2025 at 4:45 PM
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
December 2, 2025 at 8:15 PM
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
December 2, 2025 at 7:30 PM
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
December 2, 2025 at 7:00 PM
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
December 2, 2025 at 6:30 PM
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
December 2, 2025 at 5:45 PM
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
December 2, 2025 at 5:00 PM
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience