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Rockefeller University Press @rupress.org · 15h

See companion study from Grech et al. @jimenezruizlab.bsky.social @meissnerlab.bsky.social: rupress.org/jcb/article/...

Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery

Cubillán-Marín et al. find that the vesicle adaptors AP-1, AP-3, and AP-4 are all important for the survival of malaria blood-stage parasites and that thes

rupress.org

Rockefeller University Press @rupress.org · 15h

@jcb.org: Cubillán-Marín et al find that the vesicle adaptors AP-1, AP-3 & AP-4 are all important for the survival of #malaria blood-stage parasites w/ an unexpected degree of similarity but also surprising differences to the vesicle adaptor machinery in model organisms rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 15h

See companion study from the Tobias Spielmann group: rupress.org/jcb/article/...

Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery

Cubillán-Marín et al. find that the vesicle adaptors AP-1, AP-3, and AP-4 are all important for the survival of malaria blood-stage parasites and that thes

rupress.org

Rockefeller University Press @rupress.org · 15h

In @jcb.org, Grech, @meissnerlab.bsky.social et al. show that #Toxoplasma gondii tepsin interacts with the AP4 adaptor complex & #clathrin to mediate #actin- and #myosin F–dependent vesicle trafficking from the trans-#Golgi to the parasite’s #lysosome-like PLVAC rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 16h

In @jem.org, Yang, Farber and colleagues @columbiamed.bsky.social show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. rupress.org/jem/article/...

#InnateImmunity #MucosalImmunology

Rockefeller University Press @rupress.org · 18h

In @jem.org, the Jinyang Gu group show that ADK removes adenosine to license PRMT5-mediated RIPK1 R606 symmetric dimethylation. The methylation inhibits death domain–mediated RIPK1 dimerization, which suppresses TNFα-induced cell death. rupress.org/jem/article/...

#Metabolism

Rockefeller University Press @rupress.org · 3d

Spotlight @jcb.org: Anant Menon @weillcornell.bsky.social discusses recent advances by Li, Suzuki et al. (rupress.org/jcb/article/...), identifying a DLO-pyrophosphatase (Llp1), which maintains DLO quality control in eukaryotes. rupress.org/jcb/article/...

#lipid #Organelles #Glycosylation

Rockefeller University Press @rupress.org · 3d

@jgp.org Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. From Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

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Rockefeller University Press @rupress.org · 3d

In @jcb.org, Hongli Li, Marc Fransen et al. identify PEX14 as a key link between optineurin and the autophagic machinery in #pexophagy, the selective degradation of #peroxisomes. This discovery advances our understanding of #peroxisome clearance and disease. rupress.org/jcb/article/...

#Autophagy

Rockefeller University Press @rupress.org · 4d

@anne-puel.bsky.social @casanovalab.bsky.social

Rockefeller University Press @rupress.org · 4d

In @jhumimmunity.org, Vemula, Pinzon-Charry et al. describe a novel heterozygous variant in AIRE in 3 individuals w/ mild #APECED. This variant was validated as being pathogenic by a mechanism of negative dominance. This represents new cases of autosomal dominant APECED. rupress.org/jhi/article/...

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Rockefeller University Press @rupress.org · 4d

In @jem.org, Idorn, Paludan et al. @au.dk characterize a mouse strain harboring a mutation found in a herpes simplex encephalitis patient. Defective IFN-driven antiviral responses led to hyperactivation of #inflammation, contributing to disease development. rupress.org/jem/article/...

Rockefeller University Press @rupress.org · 4d

Virus imprinting matters: OC43-primed S2 antibodies show neutralizing potential and broad activity across five beta-#coronavirus subgenera, while #SARSCoV2-primed S2 antibodies remain narrow to sarbecoviruses and are largely non-neutralizing. @jem.org from Changrob et al. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 4d

New in @jcb.org: Magliozzi, Goode and colleagues @brandeisuniversity.bsky.social report that fungal proteins form a 'composite' #actin nucleator and pointed end capper. rupress.org/jcb/article/...

#Cytoskeleton #Biochemistry

Rockefeller University Press @rupress.org · 5d

New @jcb.org study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...

#membrane #lipid

Rockefeller University Press @rupress.org · 6d

New in @jhumimmunity.org: Noori et al. use recently developed in vitro technology to define the function of a previously uncharacterized STX11 mutation L135P in a patient w/ atypical familial hemophagocytic lymphohistiocytosis. rupress.org/jhi/article/...
@petermaccc.bsky.social

Partial STX11 deficiency due to a hypomorphic variant—self-limiting inflammatory disease preceding HLH onset | Journal of Human Immunity | Rockefeller University Press

Recently developed in vitro technology was used to define the function of a previously uncharacterized STX11 mutation L135P present in a patient with atypi

rupress.org

Rockefeller University Press @rupress.org · 6d

Xu et al show in @jem.org that the cGAS-TREX1 axis forms a critical feedback loop in MSI-H/dMMR tumors. Trex1 loss amplifies tumor-intrinsic cGAS–STING signaling & activates CD8+ T cell–mediated antitumor immunity, highlighting TREX1 inhibition’s therapeutic potential

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

This study demonstrates that the cGAS-TREX1 axis forms a critical negative feedback loop, enabling immune evasion in MSI-H/dMMR tumors. They revealed that

rupress.org

Rockefeller University Press @rupress.org · 6d

In @jgp.org, Scala et al @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles show enhanced fatiguing that was reversed by the KATP inhibitor glibenclamide

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

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Rockefeller University Press @rupress.org · 6d

In @jgp.org, Scala et al @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles show enhanced fatiguing that was reversed by the KATP channel inhibitor glibenclamide

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

Rockefeller University Press @rupress.org · 6d

In @jgp.org, Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, & Rubem Carlos Araújo Guedes reveal that dopaminergic signaling influences cortical excitability and cortical spreading depression dynamics, offering new mechanistic insights into dopamine’s cortical role.

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Topical application of D2 receptor ligands modulates CSD propagation in a ligand- and time-dependent manner. Electrophysiological and immunohistochemical a

rupress.org

Rockefeller University Press @rupress.org · 7d

Congratulations to @jem.org advisory editor Shimon Sakaguchi, along with Mary Brunkow and Fred Ramsdell, on winning the 2025 #Nobel Prize in Physiology or Medicine for their groundbreaking discoveries on peripheral immune tolerance

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Rockefeller University Press @rupress.org · 7d

In @jhumimmunity.org Tiago Santos de Oliveira, Antonio Condino-Neto et al. describe #CGD #epidemiology in Latin America, highlighting high infection risks, limited treatment options, & poor survival rates, esp. for males w/ XL-CGD rupress.org/jhi/article/...

@lasidofficial.bsky.social

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Rockefeller University Press @rupress.org · 7d

@jcb.org's October issue is out! rupress.org/jcb/issue/22...
The cover shows early postnatal mouse cortex w/ #astrocytes (magenta) & their #mitochondria (green) in a model of inhibited astrocytic mitochondrial fission. See Rodriguez Salazar @caglaeroglu.bsky.social et al rupress.org/jcb/article/...

Rockefeller University Press @rupress.org · 7d

@jem.org's October issue is here! rupress.org/jem/issue/22...
The cover image shows the lung of a mouse infected with M. #tuberculosis stained for #neutrophils (orange) normal lung parenchyma (blue), collagen (white) & CD4 T cells (green). See @bengern.bsky.social et al rupress.org/jem/article/...

Rockefeller University Press @rupress.org · 10d

#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...

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