Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
December 3, 2025 at 8:15 PM
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
December 3, 2025 at 7:45 PM
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
December 3, 2025 at 7:15 PM
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
December 3, 2025 at 6:45 PM
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
December 3, 2025 at 6:15 PM
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
December 3, 2025 at 5:45 PM
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
Reposted by Rockefeller University Press
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wed. December 31. Don’t miss your chance to have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025
#CellBio2025
December 3, 2025 at 4:30 PM
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wed. December 31. Don’t miss your chance to have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025
#CellBio2025
Reposted by Rockefeller University Press
Attending #CellBio2025 this weekend and interested in discussing your research with JCB editors? Our editorial team will be available:
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
December 3, 2025 at 4:02 PM
Attending #CellBio2025 this weekend and interested in discussing your research with JCB editors? Our editorial team will be available:
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
🗓️ Sunday, Dec. 7, 1:00 pm–4:00 pm
🗓️ Monday, Dec. 8, 12:00 pm–4:00 pm
🗓️ Tuesday, Dec. 9, 12:00 pm–3:00 pm
📍 Booth #1224
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
December 3, 2025 at 5:15 PM
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
Reposted by Rockefeller University Press
Attending #CellBio2025 this weekend? Be sure to visit us at Journal of Cell Biology Booth #1224 to chat about the journal, pick up a copy of The Year in Cell Biology: 2025 magazine 📕, and grab one of our exclusive puzzles 🧩
See our annual collection: rupress.org/jcb/collecti...
See our annual collection: rupress.org/jcb/collecti...
December 3, 2025 at 3:45 PM
Attending #CellBio2025 this weekend? Be sure to visit us at Journal of Cell Biology Booth #1224 to chat about the journal, pick up a copy of The Year in Cell Biology: 2025 magazine 📕, and grab one of our exclusive puzzles 🧩
See our annual collection: rupress.org/jcb/collecti...
See our annual collection: rupress.org/jcb/collecti...
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
December 3, 2025 at 4:45 PM
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
December 2, 2025 at 8:15 PM
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
December 2, 2025 at 7:30 PM
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
December 2, 2025 at 7:00 PM
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
December 2, 2025 at 6:30 PM
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
December 2, 2025 at 5:45 PM
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
December 2, 2025 at 5:00 PM
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
@jem.org's December Issue is here! rupress.org/jem/issue/22...
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
December 1, 2025 at 3:15 PM
@jem.org's December Issue is here! rupress.org/jem/issue/22...
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
@jcb.org December issue is here! rupress.org/jcb/issue/22...
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
December 1, 2025 at 3:02 PM
@jcb.org December issue is here! rupress.org/jcb/issue/22...
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
🔔 @jhumimmunity.org is delighted to share the abstracts from the 2025 Conference of the Australasian Society of Clinical Immunology and Allergy (#ASCIA). Explore the latest advancements in clinical grand rounds and inborn errors of immunity 👉 rupress.org/jhi/issue/1/...
November 26, 2025 at 7:45 PM
🔔 @jhumimmunity.org is delighted to share the abstracts from the 2025 Conference of the Australasian Society of Clinical Immunology and Allergy (#ASCIA). Explore the latest advancements in clinical grand rounds and inborn errors of immunity 👉 rupress.org/jhi/issue/1/...
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
November 26, 2025 at 7:15 PM
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
Spotlight @jcb.org: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
November 26, 2025 at 6:45 PM
Spotlight @jcb.org: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
In @jem.org, Kurz et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
November 26, 2025 at 6:00 PM
In @jem.org, Kurz et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
@jgp.org: Zhou, @chris-lingle.bsky.social et al ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent w/ a trinomial model of random mixing of β subunits rupress.org/jgp/article/...
November 25, 2025 at 8:00 PM
@jgp.org: Zhou, @chris-lingle.bsky.social et al ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent w/ a trinomial model of random mixing of β subunits rupress.org/jgp/article/...
In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
November 25, 2025 at 7:30 PM
In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology