Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
In @jem.org, Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology
#Hematopoiesis #LymphocyteBiology
December 4, 2025 at 5:00 PM
In @jem.org, Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology
#Hematopoiesis #LymphocyteBiology
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
December 3, 2025 at 8:15 PM
Hiro Furukawa @lab-furukawa.bsky.social provides commentary on new @jgp.org study by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
December 3, 2025 at 7:45 PM
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. In @jem.org, Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
December 3, 2025 at 7:15 PM
In @jcb.org, Kun Gao et al. show that a specific long noncoding RNA EGFR-AS1 directly facilitates the repair of broken DNA. Targeting this RNA effectively sensitizes lung #cancer cells to #chemotherapy, offering a promising strategy to overcome treatment resistance. rupress.org/jcb/article/...
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
December 3, 2025 at 6:45 PM
In @jhumimmunity.org, Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...
@casanovalab.bsky.social
@casanovalab.bsky.social
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
December 3, 2025 at 6:15 PM
New study in @jgp.org from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
December 3, 2025 at 5:45 PM
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
December 3, 2025 at 5:15 PM
In @jcb.org, @valthomas.bsky.social et al. @sophiemartinlab.bsky.social provide a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
December 3, 2025 at 4:45 PM
@jcb.org's annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
#CellBio2025
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
December 2, 2025 at 8:15 PM
In @jcb.org, Arends, Bennett, & Tapscott @fredhutch.org show that DUX4-induction of stable intranuclear RNA, including pericentromeric HSATII repeat RNA, leads to nuclear protein aggregation. HSATII RNP complexes impact RNA processing downstream of DUX4 expression rupress.org/jcb/article/...
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
December 2, 2025 at 7:30 PM
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
#Membrane #lipid
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
December 2, 2025 at 7:00 PM
In @jcb.org, Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
December 2, 2025 at 6:30 PM
In @jgp.org, Sharma, Goldfarb et al. show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
December 2, 2025 at 5:45 PM
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
December 2, 2025 at 5:00 PM
In @jcb.org, Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
@jem.org's December Issue is here! rupress.org/jem/issue/22...
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
December 1, 2025 at 3:15 PM
@jem.org's December Issue is here! rupress.org/jem/issue/22...
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See @wjbranchett.bsky.social et al.: doi.org/10.1084/jem....
@jcb.org December issue is here! rupress.org/jcb/issue/22...
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
December 1, 2025 at 3:02 PM
@jcb.org December issue is here! rupress.org/jcb/issue/22...
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
Cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
🔔 @jhumimmunity.org is delighted to share the abstracts from the 2025 Conference of the Australasian Society of Clinical Immunology and Allergy (#ASCIA). Explore the latest advancements in clinical grand rounds and inborn errors of immunity 👉 rupress.org/jhi/issue/1/...
November 26, 2025 at 7:45 PM
🔔 @jhumimmunity.org is delighted to share the abstracts from the 2025 Conference of the Australasian Society of Clinical Immunology and Allergy (#ASCIA). Explore the latest advancements in clinical grand rounds and inborn errors of immunity 👉 rupress.org/jhi/issue/1/...
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
November 26, 2025 at 7:15 PM
In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
Spotlight @jcb.org: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
November 26, 2025 at 6:45 PM
Spotlight @jcb.org: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
In @jem.org, Kurz et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
November 26, 2025 at 6:00 PM
In @jem.org, Kurz et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
@jgp.org: Zhou, @chris-lingle.bsky.social et al ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent w/ a trinomial model of random mixing of β subunits rupress.org/jgp/article/...
November 25, 2025 at 8:00 PM
@jgp.org: Zhou, @chris-lingle.bsky.social et al ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent w/ a trinomial model of random mixing of β subunits rupress.org/jgp/article/...
In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
November 25, 2025 at 7:30 PM
In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
In @jcb.org, Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...
#lysosomes
#lysosomes
November 25, 2025 at 7:00 PM
In @jcb.org, Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...
#lysosomes
#lysosomes
🎉 Congratulations to Yu Deng, winner of the @jcb.org 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter Devreotes’ lab at @jhu.edu. Be sure to catch Yu’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...
November 24, 2025 at 3:45 PM
🎉 Congratulations to Yu Deng, winner of the @jcb.org 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter Devreotes’ lab at @jhu.edu. Be sure to catch Yu’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...