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wythelab.bsky.social
Wythe Lab at UVA School of Medicine
@wythelab.bsky.social
1.8K followers 650 following 430 posts
Vascular biologist. Brain AVMs and Kras, glioblastoma and angiogenesis, lymphatics, and developmental biology.

https://www.wythelab.com
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wythelab.bsky.social
Wythe Lab at UVA School of Medicine @wythelab.bsky.social · Mar 17
Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh
Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
Nature Cardiovascular Research - Cantu Gutierrez et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs throughout development, and...
go.nature.com
Reposted by Wythe Lab at UVA School of Medicine
qasimrashid.com
The first time terrorists used planes to attack Americans wasn’t on 9/11 or at Pearl Harbor. It was the Tulsa Race Massacre of 1921 when white supremacists flew a dozen planes to drop turpentine or nitroglycerin bombs on Black Americans.

Viola Fletcher was there.
www.qasimrashid.com/p/viola-flet...
Viola Fletcher, Among Last Known Survivors of Tulsa Race Massacre, Dies at 111
Mother Fletcher's legacy will live on as the epitome of honor, courage, strength, and resilience in the face of violent terrorism, white supremacy, and cowardice
www.qasimrashid.com
November 25, 2025 at 11:14 PM
Reposted by Wythe Lab at UVA School of Medicine
devbiol.bsky.social
#DBfeature 🐠

A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.

By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss

tinyurl.com/ve5vzp6c
A. Schematic of imaging experiment, with drawings of zebrafish larvae at 3dpf and 7dpf underneath a timeline of imaging every 8 hours. B. (Top) Heatmap of Erk activity at single cell resolution; (Bottom) Raw images of Erk-KTR-mCerulean signal. Scale bar: 100 μm.
November 25, 2025 at 12:35 PM
Reposted by Wythe Lab at UVA School of Medicine
phillewis.bsky.social
Breaking: Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old
Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died
Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old.
www.whatimreading.net
November 24, 2025 at 8:45 PM
Reposted by Wythe Lab at UVA School of Medicine
jeremymberg.bsky.social
This is concerning.

NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).

1/2
An internal document from NIH which states that documentation must be provide for each funded grant but that no documentation need be provided for applications that are not selected for funding including those that are skipped back on overall impact scores.
November 24, 2025 at 12:29 AM
Reposted by Wythe Lab at UVA School of Medicine
epimechfc.bsky.social
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
Reposted by Wythe Lab at UVA School of Medicine
joachimgoedhart.bsky.social
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
Fig. 1: Rapid degradation of postsynaptic scaffold proteins fused to mTurquoise2 and a mAID degron.
November 22, 2025 at 7:59 PM
Reposted by Wythe Lab at UVA School of Medicine
owoolnough.bsky.social
As it's hiring season again I'm resharing the NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for an RA, PhD, Postdoc, or faculty position in Neuro or an adjacent field.

bsky.app/profile/did:...
September 3, 2025 at 3:25 PM
Reposted by Wythe Lab at UVA School of Medicine
tedpricethepainguy.bsky.social
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Reposted by Wythe Lab at UVA School of Medicine
clarajeffery.bsky.social
MAHA

www.washingtonpost.com/climate-envi...
EPA just approved new ‘forever chemical’ pesticides for use on food
Critics warn the EPA’s approvals of new PFAS pesticides could expose more Americans to “forever chemicals” through their food.
www.washingtonpost.com
November 22, 2025 at 11:00 AM
Reposted by Wythe Lab at UVA School of Medicine
maxkozlov.bsky.social
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.

Here's what I saw. 🧵 🧪

www.nature.com/articles/d41...
A glorious selfie with the official MAHA lanyard seconds after I made it past Secret Service screening.
November 21, 2025 at 5:01 PM
Reposted by Wythe Lab at UVA School of Medicine
drugmonkey.bsky.social
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important.
A new webpage on the NIH site called “Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions” is causing a small kerfuffle on the socials. As per us…
drugmonkey.wordpress.com
November 22, 2025 at 12:26 AM
wythelab.bsky.social
November 21, 2025 at 10:55 PM
Reposted by Wythe Lab at UVA School of Medicine
septinlab.bsky.social
"Going forward, ICOs will be considering peer review information in its entirety. NIH ICOs will NOT rely on funding paylines in developing pay plans. Rather, ICOs will consider these scores in context of their and NIH’s priorities, strategic plans, and budgets..."

grants.nih.gov/news-events/...
Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding
grants.nih.gov
November 21, 2025 at 10:51 PM
Reposted by Wythe Lab at UVA School of Medicine
haoyin.bsky.social
Do Not miss this great @navbo.bsky.social online event😆

Specification of Endothelial Cell Phenotypes

Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch

Abstract deadline November 20

members.navbo.org/calendar-of-...
November 13, 2025 at 7:51 PM
Reposted by Wythe Lab at UVA School of Medicine
wythelab.bsky.social
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.

Open access @dev-journal.bsky.social

journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
Reposted by Wythe Lab at UVA School of Medicine
aaronparnas.bsky.social
NEW: Epstein survivors release the most powerful PSA I have ever seen.

Make this go viral so every member of the House of Representatives sees it.
November 16, 2025 at 11:43 PM
Reposted by Wythe Lab at UVA School of Medicine
kwolbachia.bsky.social
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
Reposted by Wythe Lab at UVA School of Medicine
haoyin.bsky.social
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater

#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
November 15, 2025 at 11:20 PM
wythelab.bsky.social
Such an iconic album. Insane.
dytsras.bsky.social Ida B Wells' Winchester Rifle @dytsras.bsky.social · 11d
In a world long forgotten, Jay-Z released his final album 22 years ago today.

And ill never forget the first time I heard "What More Can I Say."

Music just dont feel the same anymore. I rode the bus to Best Buy to get this album. What a time

"Ayo wassup pimp, this threats!!"
Screenshot of Jay-Z "The Black Album" cover. Released November 14, 2003
November 15, 2025 at 1:45 AM
Reposted by Wythe Lab at UVA School of Medicine
bakerdphd.bsky.social
"The Cavalier Daily corresponded with former Rector Robert Hardie, whose term ended June 30, regarding the two accounts. He confirmed that he agreed with Ryan’s account.

'I concur fully with President Ryan’s recollection of events,' Hardie said."

Welp

www.cavalierdaily.com/article/2025...
Ryan and Sheridan provide full accounts of Ryan’s resignation. They differ significantly
“I concur fully with President Ryan’s recollection of events,” former Board Rector Robert Hardie said.
www.cavalierdaily.com
November 14, 2025 at 7:46 PM
Reposted by Wythe Lab at UVA School of Medicine
addgene.bsky.social
MAGIC Toolbox: MultiSite Assembly of Gateway Induced Clones ✨🧬 Thanks for sharing @wythelab.bsky.social!
Find the plasmids here: www.addgene.org/browse/artic...
November 14, 2025 at 7:28 PM
wythelab.bsky.social
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.

Open access @dev-journal.bsky.social

journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
Reposted by Wythe Lab at UVA School of Medicine
dytsras.bsky.social
108 years ago, the US military carried out the largest mass execution in American history. In December 1917, the military hanged 13 soldiers. Another 6 were hanged less than a year later.

Yes...they were all Black soldiers.

It's best known as the Houston Riot of 1917

🧵
November 13, 2025 at 10:37 PM
Reposted by Wythe Lab at UVA School of Medicine
tomonroe.bsky.social
See my pinned thread. Happy to have this version out!
November 12, 2025 at 10:20 PM
Reposted by Wythe Lab at UVA School of Medicine
travisyork.bsky.social
Proud to share L'Oréal USA’s 2025 For Women in Science awardees — five brilliant women driving discovery & innovation in STEM. Honored to be quoted in the release. 🌍🧪
Read: prn.to/3Xsnila
@aaas.org @aaascsew.bsky.social #WomenInSTEM #ForWomenInScience #L'OrealUSA
L'Oréal USA Announces 2025 For Women in Science Awardees, Underscoring Commitment to Advancing Careers in STEM
/PRNewswire/ -- Today, L'Oréal USA revealed the 2025 For Women in Science (FWIS) awardees, providing five women postdoctoral scientists grants to advance their...
prn.to
November 12, 2025 at 11:09 PM