Background Falls are a leading cause of injury and death in older adults (age ≥ 65 years). The onset of the COVID-19 pandemic in the United States (US) marked a transition into a period of greater s...

Additive electronic air cleaners like ionizers, photocatalytic oxidizers, and plasma devices intentionally release reactive species into indoor air so that they may inactivate infectious airborne pathogens. Third-party commercial testing and peer-reviewed studies alike typically report inactivation metrics in terms of percent- or log-reductions observed from chamber experiments that imply a nearly complete elimination of infection risks. However, these metrics are highly dependent upon the experimental volume and duration, so they do not directly translate to actual effectiveness indoors. We reviewed 45 experiments across 14 published studies and converted reported reduction metrics into equivalent clean airflow rates (ECA). Different studies yielded distinct ECA distributions, suggesting that differences in experimental procedures, device specifications, or environmental conditions may be more important ECA determinants than the target pathogen or the underlying device technology. Study-averaged ECAs spanned between 1.4 and 134 m3/h, with the median study having an average ECA = 31 m3/h. Even small off-the-shelf HEPA-filter air cleaners typically provide ECAs that exceed the best-performing additive devices analyzed herein. Their low efficacy relative to alternatives, environmental factors that can affect performance, and chemical byproduct concerns are discussed in the context of test standard development and system selection.

This Primer by Wilson and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of neurological and psychiatric manifestations of COVID-19.

Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives cytokine-induced cardiac injury.

This JAMA Pediatrics Patient Page describes the symptoms of long COVID in children.

Robert F. Kennedy Jr.'s vaccine advisers will vote this week on whether to delay hepatitis B shots for most American children, the new chair of the committee said, a move that would be the most conseq...

Post-acute sequelae of SARS-CoV-2 (PASC) have been linked to brain alterations, but association with cognitive problems are not well understood. Here, the authors analyze blood proteins and brain MRI ...

Nature - Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.