Josiah
@stackjanton99.bsky.social
|unfortunately very sincere|Jeopardy alum|big fan of the yorkshire dales|space🚀|🇺🇸🏴 🇨🇲| |#GoHabsGo
Reposted by Josiah
It's that time of year when Americans set up quaint, walkable Christmas villages in their living rooms, dreaming of living in such a cozy place.
Meanwhile, they'll show up to city council meetings to fiercely oppose any plan that would actually build that kind of car-lite community in real life.
Meanwhile, they'll show up to city council meetings to fiercely oppose any plan that would actually build that kind of car-lite community in real life.
November 23, 2025 at 3:13 AM
It's that time of year when Americans set up quaint, walkable Christmas villages in their living rooms, dreaming of living in such a cozy place.
Meanwhile, they'll show up to city council meetings to fiercely oppose any plan that would actually build that kind of car-lite community in real life.
Meanwhile, they'll show up to city council meetings to fiercely oppose any plan that would actually build that kind of car-lite community in real life.
Reposted by Josiah
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
November 26, 2025 at 9:10 PM
Prof. Laura Dassama (Stanford Chem) is developing a small-molecule therapy for sickle cell disease that removes BCL11A, restoring fetal hemoglobin without gene editing. Her goal is a simpler, more affordable sickle cell therapy. brnw.ch/21wXP8k
Reposted by Josiah
REVIEW | R Mancina, L Valenti, @stefano-romeo.bsky.social (U Rome, U Milan, U Gothenburg):
The genetic underpinnings of MASLD and causal associations with T2D and insulin resistance. 🧪
The genetic underpinnings of MASLD and causal associations with T2D and insulin resistance. 🧪
Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism - Nature Metabolism
This Review summarizes our current knowledge about the genetic underpinnings of metabolic-dysfunction-associated steatotic liver disease and highlights its causal association with type 2 diabetes and insulin resistance.
bit.ly
November 25, 2025 at 8:01 PM
REVIEW | R Mancina, L Valenti, @stefano-romeo.bsky.social (U Rome, U Milan, U Gothenburg):
The genetic underpinnings of MASLD and causal associations with T2D and insulin resistance. 🧪
The genetic underpinnings of MASLD and causal associations with T2D and insulin resistance. 🧪
Reposted by Josiah
This new gene editing strategy ignores nonsense mutations that produce a truncated protein instead of "repairing" the gene. This allows more patients to be treated.
There is some hope cystic fibrosis & Duchenne muscular dystrophy. This study was #NIH funded.
🧪🎁🔗 www.nytimes.com/2025/11/19/h...
There is some hope cystic fibrosis & Duchenne muscular dystrophy. This study was #NIH funded.
🧪🎁🔗 www.nytimes.com/2025/11/19/h...
New Gene-Editing Strategy Could Help Development of Treatments for Rare Diseases
www.nytimes.com
November 25, 2025 at 9:09 PM
This new gene editing strategy ignores nonsense mutations that produce a truncated protein instead of "repairing" the gene. This allows more patients to be treated.
There is some hope cystic fibrosis & Duchenne muscular dystrophy. This study was #NIH funded.
🧪🎁🔗 www.nytimes.com/2025/11/19/h...
There is some hope cystic fibrosis & Duchenne muscular dystrophy. This study was #NIH funded.
🧪🎁🔗 www.nytimes.com/2025/11/19/h...
Reposted by Josiah
+ every $1 invested in NIH research returns ~$1.47 to the economy
Every $1 invested in women’s health returns $3! to the economy.
It’s clear who is not valued in this society.
Every $1 invested in women’s health returns $3! to the economy.
It’s clear who is not valued in this society.
To recap:
•Universal healthcare would save 68,000 lives & $450B annually
•Every $1 spent on SNAP results in $1.80 boost to local economies & small businesses
•The child tax credit decreased child poverty to a historic low of 5.2%, abolishing it increased it by 45%
1/2
•Universal healthcare would save 68,000 lives & $450B annually
•Every $1 spent on SNAP results in $1.80 boost to local economies & small businesses
•The child tax credit decreased child poverty to a historic low of 5.2%, abolishing it increased it by 45%
1/2
November 25, 2025 at 5:00 PM
+ every $1 invested in NIH research returns ~$1.47 to the economy
Every $1 invested in women’s health returns $3! to the economy.
It’s clear who is not valued in this society.
Every $1 invested in women’s health returns $3! to the economy.
It’s clear who is not valued in this society.
Reposted by Josiah
An uptick in peanut allergies in children around the turn of the century prompted parents to avoid peanut exposure. But updated research showed that early introduction is both safe and effective at reducing allergies.
🎙️ @drdavidhill.bsky.social
🎧 podcast.publichealth.jhu.edu/980-why-earl...
🎙️ @drdavidhill.bsky.social
🎧 podcast.publichealth.jhu.edu/980-why-earl...
November 25, 2025 at 5:07 PM
An uptick in peanut allergies in children around the turn of the century prompted parents to avoid peanut exposure. But updated research showed that early introduction is both safe and effective at reducing allergies.
🎙️ @drdavidhill.bsky.social
🎧 podcast.publichealth.jhu.edu/980-why-earl...
🎙️ @drdavidhill.bsky.social
🎧 podcast.publichealth.jhu.edu/980-why-earl...
Reposted by Josiah
🎯 CTCA: Enlarged right atrium and ventricle with a wide secundum ASD. Coronaries show multifocal calcification and the aortic root is dilated.
🎯 Secundum ASD is the commonest interatrial septal defect, located at the fossa ovalis.
👤 Craig Hacking, radiopaedia.org/cases/206028
🎯 Secundum ASD is the commonest interatrial septal defect, located at the fossa ovalis.
👤 Craig Hacking, radiopaedia.org/cases/206028
November 25, 2025 at 5:08 PM
🎯 CTCA: Enlarged right atrium and ventricle with a wide secundum ASD. Coronaries show multifocal calcification and the aortic root is dilated.
🎯 Secundum ASD is the commonest interatrial septal defect, located at the fossa ovalis.
👤 Craig Hacking, radiopaedia.org/cases/206028
🎯 Secundum ASD is the commonest interatrial septal defect, located at the fossa ovalis.
👤 Craig Hacking, radiopaedia.org/cases/206028
Reposted by Josiah
A new theory helps explain blood clots complications in COVID-19
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
November 25, 2025 at 5:15 PM
A new theory helps explain blood clots complications in COVID-19
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
Reposted by Josiah
this is what ten years of obsession with "wokeness" in the media was trying to get to btw bsky.app/profile/mari...
November 25, 2025 at 4:04 PM
this is what ten years of obsession with "wokeness" in the media was trying to get to btw bsky.app/profile/mari...
Reposted by Josiah
An education in tolerance: the 2025 Nobel Prize in Physiology or Medicine
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
November 20, 2025 at 10:13 AM
An education in tolerance: the 2025 Nobel Prize in Physiology or Medicine
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
ship of FOOLS
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 11:33 AM
ship of FOOLS
HAITI ARE GOING TO THE WORLD CUP FOR THE FIRST TIME SINCE 1974
C'EST BONNNNNNNN
C'EST BONNNNNNNN
November 19, 2025 at 3:03 AM
HAITI ARE GOING TO THE WORLD CUP FOR THE FIRST TIME SINCE 1974
C'EST BONNNNNNNN
C'EST BONNNNNNNN
Reposted by Josiah
Why do we vaccinate newborns for Hepatitis B?
It SAVES LIVES. It prevents infection & acute illness but ALSO
• Chronic Hepatitis
• Liver failure
• Cancer
• Death
Babies are at HIGHEST risk for severe outcomes from hepatitis B if infected.
Watch:
youtu.be/W8CMfMuN1bI?si
1/
It SAVES LIVES. It prevents infection & acute illness but ALSO
• Chronic Hepatitis
• Liver failure
• Cancer
• Death
Babies are at HIGHEST risk for severe outcomes from hepatitis B if infected.
Watch:
youtu.be/W8CMfMuN1bI?si
1/
Newborn Hepatitis B Vaccination Prevents Chronic Disease And Saves Lives
YouTube video by Andrea Love, PhD
youtu.be
November 5, 2025 at 1:15 AM
Why do we vaccinate newborns for Hepatitis B?
It SAVES LIVES. It prevents infection & acute illness but ALSO
• Chronic Hepatitis
• Liver failure
• Cancer
• Death
Babies are at HIGHEST risk for severe outcomes from hepatitis B if infected.
Watch:
youtu.be/W8CMfMuN1bI?si
1/
It SAVES LIVES. It prevents infection & acute illness but ALSO
• Chronic Hepatitis
• Liver failure
• Cancer
• Death
Babies are at HIGHEST risk for severe outcomes from hepatitis B if infected.
Watch:
youtu.be/W8CMfMuN1bI?si
1/
Reposted by Josiah
There's also a weird conventional wisdom forming that the Democratic agenda is toxically unpopular and that Republicans are delivering what voters want.
This is laughably false. Trump is the most unpopular president in modern history and his entire agenda is underwater.
This is laughably false. Trump is the most unpopular president in modern history and his entire agenda is underwater.
November 2, 2025 at 1:51 PM
There's also a weird conventional wisdom forming that the Democratic agenda is toxically unpopular and that Republicans are delivering what voters want.
This is laughably false. Trump is the most unpopular president in modern history and his entire agenda is underwater.
This is laughably false. Trump is the most unpopular president in modern history and his entire agenda is underwater.
Presented without comment
October 31, 2025 at 8:46 PM
Presented without comment
Reposted by Josiah
This review highlights how #mtDNA integrity influences #Cardiomyocyte injury in #Ischemia/#Reperfusion and explores therapeutic approaches that target #mtDNA to protect the #Heart. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
October 28, 2025 at 12:51 AM
This review highlights how #mtDNA integrity influences #Cardiomyocyte injury in #Ischemia/#Reperfusion and explores therapeutic approaches that target #mtDNA to protect the #Heart. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Reposted by Josiah
Things are at a standstill with the govt shutdown, the year has been one of 'constant chaos' at the NIH — & the worst may be yet to come folks said on my panel
Read a recap of our talk w/ @jeremymberg.bsky.social @malar0ne.bsky.social & Eric Green here
www.statnews.com/2025/10/16/f...
Read a recap of our talk w/ @jeremymberg.bsky.social @malar0ne.bsky.social & Eric Green here
www.statnews.com/2025/10/16/f...
Former NIH leaders lament ‘constant chaos’ at the agency, and caution it’s not over
“It's been like living in a washing machine, it's been constant chaos,” former NIH official Jeremy Berg said at the #STATSummit
www.statnews.com
October 16, 2025 at 8:31 PM
Things are at a standstill with the govt shutdown, the year has been one of 'constant chaos' at the NIH — & the worst may be yet to come folks said on my panel
Read a recap of our talk w/ @jeremymberg.bsky.social @malar0ne.bsky.social & Eric Green here
www.statnews.com/2025/10/16/f...
Read a recap of our talk w/ @jeremymberg.bsky.social @malar0ne.bsky.social & Eric Green here
www.statnews.com/2025/10/16/f...
Reposted by Josiah
In the rural South where Medicaid has been a lifeline, residents brace for cuts www.npr.org/sections/sho...
In the rural South where Medicaid has been a lifeline, residents brace for cuts
With Medicaid cutbacks on the horizon, millions in the U.S. are expected to go uninsured. In the Mississippi Delta region — one of the poorest places in the U.S. — people are stressed and mad.
www.npr.org
October 25, 2025 at 7:23 PM
In the rural South where Medicaid has been a lifeline, residents brace for cuts www.npr.org/sections/sho...
Reposted by Josiah
Three points. Four goals. Three Premier League wins in a row.
Another 3-4-3 Ruben Amorim can get behind...
Analysis of Manchester United 4-2 Brighton from @mjcritchley.bsky.social ⤵️
Another 3-4-3 Ruben Amorim can get behind...
Analysis of Manchester United 4-2 Brighton from @mjcritchley.bsky.social ⤵️
Man Utd 4 Brighton 2 – What has Ruben Amorim improved to earn three successive wins?
Analysis of Manchester United's victory over Brighton in the Premier League
www.nytimes.com
October 25, 2025 at 6:50 PM
Three points. Four goals. Three Premier League wins in a row.
Another 3-4-3 Ruben Amorim can get behind...
Analysis of Manchester United 4-2 Brighton from @mjcritchley.bsky.social ⤵️
Another 3-4-3 Ruben Amorim can get behind...
Analysis of Manchester United 4-2 Brighton from @mjcritchley.bsky.social ⤵️
Reposted by Josiah
Manchester United have won three Premier League matches in a row.
Goals from Matheus Cunha, Casemiro and a Bryan Mbeumo brace secure all three points, despite a late Brighton rally.
Goals from Matheus Cunha, Casemiro and a Bryan Mbeumo brace secure all three points, despite a late Brighton rally.
October 25, 2025 at 6:30 PM
Manchester United have won three Premier League matches in a row.
Goals from Matheus Cunha, Casemiro and a Bryan Mbeumo brace secure all three points, despite a late Brighton rally.
Goals from Matheus Cunha, Casemiro and a Bryan Mbeumo brace secure all three points, despite a late Brighton rally.
Reposted by Josiah
I’m in Paris right now and have noticed “school street” mentioned as a desirable feature in real estate ads. No cars = higher property value, it seems
“In a city once choked with cars and infamous for its traffic snarls, Paris has pulled off a remarkable turnaround…the French capital has officially become Europe’s best city for children to walk, cycle, and move around independently.” Via @momentummag.bsky.social
A victory for FAST leadership.
A victory for FAST leadership.
Paris Pedals to the Top: How the City of Light Became Europe’s Best for Young Cyclists
The French capital has officially become Europe’s best city for children to walk, cycle, and move around independently
momentummag.com
October 9, 2025 at 7:56 PM
I’m in Paris right now and have noticed “school street” mentioned as a desirable feature in real estate ads. No cars = higher property value, it seems
Reposted by Josiah
not to start a discourse here (really) but i think dems actually have been doing a pretty good job working the ballroom into their public complaints and communications, even if it's not really breaking through in the media
October 25, 2025 at 7:15 PM
not to start a discourse here (really) but i think dems actually have been doing a pretty good job working the ballroom into their public complaints and communications, even if it's not really breaking through in the media
Reposted by Josiah
no word of a lie
It’s the greatest week of football season: the week where my team doesn’t play
October 25, 2025 at 7:33 PM
no word of a lie