Without the mathematical model that she helped refine, “the extraordinary positioning, navigation, and timing accuracy of GPS would be impossible to achieve.”

The agency plays a key role in tracking the disease spread and vaccination rates. Last year, it seemed to back away from some of that work, according to new research.

Rolling debt and seven-year loans are leaving households underwater on their car, making ownership unaffordable.

G-protein-coupled receptors act as guanine nucleotide exchange factors (GEFs) and facilitate the activation of heterotrimeric G proteins by exchanging GDP for GTP1. This exchange function is not unidirectional2. Here we demonstrate that an agonist can show selective affinity for an active state that prefers the release of GTP. Specifically, for the mu opioid receptor, we show that several agonists have state-selective affinities for promoting GTP release versus GTP binding. We identify two agonists that show a marked preference for promoting release. In mice, marginally efficacious doses of the release-preferring agonist enhance and prolong the antinociceptive effects of morphine and fentanyl without enhancing the respiratory and cardiac effects of fentanyl. Although these observations are limited to simple measures of thermal nociception, they may point to a way to bifurcate physiological responses to such agonists. We propose that the active-state selectivity of an agonist may determ

Even brief exposure can trigger lung injury, infections, and long-term breathing problems in the public.

He views the entire world as a private club he owns and profits from.

As many as four vervet monkeys were spotted in a neighborhood in North St. Louis on Thursday, city officials said. No one knows how they got there.

Song · 1995 · Duration 3:30