Mari Chiritoiu
@marichiritoiu.bsky.social
Cell biologist interested in unconventional protein secretion in health and disease. Affiliated to Institute of Biochemistry of the Romanian Academy. Mother. (She/her) Opinions my own
Reposted by Mari Chiritoiu
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 1:27 AM
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Reposted by Mari Chiritoiu
Reposted by Mari Chiritoiu
Congratulations to João Mello-Vieira on his important contribution to @natrevimmunol.nature.com, providing an in-depth analysis of how #ubiquitination and #autophagy coordinate host-pathogen interactions, spanning immune surveillance mechanisms to antimicrobial #immunity. 👏
Review @natrevimmunol.nature.com @idikic.bsky.social
Ubiquitination and autophagy in host–pathogen interactions: from immune surveillance to therapeutic targeting
www.nature.com/articles/s41...
Ubiquitination and autophagy in host–pathogen interactions: from immune surveillance to therapeutic targeting
www.nature.com/articles/s41...
January 6, 2026 at 8:57 PM
Congratulations to João Mello-Vieira on his important contribution to @natrevimmunol.nature.com, providing an in-depth analysis of how #ubiquitination and #autophagy coordinate host-pathogen interactions, spanning immune surveillance mechanisms to antimicrobial #immunity. 👏
Reposted by Mari Chiritoiu
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
ProxiCapture Reveals Context-Dependent CRBN Interactore Landscape of Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.01.05.697692v1
January 6, 2026 at 8:54 PM
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
Reposted by Mari Chiritoiu
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
doi.org
January 5, 2026 at 5:50 PM
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Reposted by Mari Chiritoiu
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
November 25, 2025 at 4:22 PM
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
Reposted by Mari Chiritoiu
Reposted by Mari Chiritoiu
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
www.embopress.org
November 20, 2025 at 3:15 PM
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Mari Chiritoiu
Join us at @icfo.eu in Barcelona next February for the 1st @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology". I am convinced it will be very interesting! We have extended the abstract submission deadline to December 8, so no excuses :) #EMBOmechanobio
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
November 12, 2025 at 4:34 PM
Join us at @icfo.eu in Barcelona next February for the 1st @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology". I am convinced it will be very interesting! We have extended the abstract submission deadline to December 8, so no excuses :) #EMBOmechanobio
Reposted by Mari Chiritoiu
ICYMI: New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus
Mechanistic insights into cargo sorting and export from the Golgi apparatus
Nature Reviews Molecular Cell Biology, Published online: 10 November 2025; doi:10.1038/s41580-025-00907-3Protein and lipid cargoes are modified and sorted in the Golgi apparatus and packaged for delivery to diverse cellular destinations at the trans-Golgi network (TGN). This Review discusses recent insights into Golgi transport mechanisms and carrier biogenesis at the TGN.
bit.ly
November 13, 2025 at 10:04 AM
ICYMI: New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus
Reposted by Mari Chiritoiu
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
Reposted by Mari Chiritoiu
Reposted by Mari Chiritoiu
If you are interested in membrane trafficking and IDPRs, please join us!
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 16, 2025 at 6:35 PM
If you are interested in membrane trafficking and IDPRs, please join us!
Reposted by Mari Chiritoiu
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 7:36 AM
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
Reposted by Mari Chiritoiu
Hard to overstate what incredible news this is.
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 3:36 PM
Hard to overstate what incredible news this is.
Reposted by Mari Chiritoiu
@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 16, 2025 at 7:03 PM
@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome
#Inflammasome
Reposted by Mari Chiritoiu
An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio
The generation of vaccines that stimulate T cell activities is an unmet need for the
scientific community, as T cells are the primary mediators of immune memory. In this
study, we report a new vaccine...
journals.asm.org
September 8, 2025 at 7:19 PM
An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
Reposted by Mari Chiritoiu
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
August 11, 2025 at 9:10 AM
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
Reposted by Mari Chiritoiu
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
www.nature.com
May 27, 2025 at 8:40 AM
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mari Chiritoiu
When the CRG's Vivek Malhotra first identified a handful of protein-coding genes called TANGO in 2006, he had no idea that one of them, TANGO2, would eventually be linked to a life-threatening disorder in children. His team has continued to study the protein since.
Science finds explanation for disease that leaves children ‘frozen’
A team from the Center for Genomic Regulation in Barcelona details the molecular mechanism of a rare illness that causes transient paralysis and dangerous arrhythmias
english.elpais.com
March 1, 2025 at 7:51 AM
When the CRG's Vivek Malhotra first identified a handful of protein-coding genes called TANGO in 2006, he had no idea that one of them, TANGO2, would eventually be linked to a life-threatening disorder in children. His team has continued to study the protein since.
Reposted by Mari Chiritoiu
Today is Rare disease day!
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
February 28, 2025 at 5:15 PM
Today is Rare disease day!
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
Reposted by Mari Chiritoiu
1/ From Brazil to South Korea, we’re excited to welcome 107 early-career researchers who are looking to promote responsible behaviours in science to the eLife Community Ambassador programme 🎉
https://buff.ly/3EYNfmE
https://buff.ly/3EYNfmE
February 27, 2025 at 3:03 PM
1/ From Brazil to South Korea, we’re excited to welcome 107 early-career researchers who are looking to promote responsible behaviours in science to the eLife Community Ambassador programme 🎉
https://buff.ly/3EYNfmE
https://buff.ly/3EYNfmE
Reposted by Mari Chiritoiu
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach
https://go.nature.com/41duwuO
https://go.nature.com/41duwuO
Woman in cancer remission for record 19 years after CAR-T immune treatment
Nature - CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.
go.nature.com
February 22, 2025 at 12:12 PM
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach
https://go.nature.com/41duwuO
https://go.nature.com/41duwuO
Reposted by Mari Chiritoiu
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
February 2, 2025 at 11:08 AM
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
Reposted by Mari Chiritoiu
This is tomorrow (Thursday) at 5pm CET, looking forward to it! cc/ @ishier.bsky.social @franbottanelli.bsky.social
January 29, 2025 at 10:36 AM
This is tomorrow (Thursday) at 5pm CET, looking forward to it! cc/ @ishier.bsky.social @franbottanelli.bsky.social