Nature Reviews Molecular Cell Biology, Published online: 08 December 2025; doi:10.1038/s41580-025-00941-1Jamieson and colleagues report the effects of spaceflight on haematopoietic stem and progenitor cells isolated from astronauts.

Nature Reviews Molecular Cell Biology, Published online: 08 December 2025; doi:10.1038/s41580-025-00941-1Jamieson and colleagues report the effects of spaceflight on haematopoietic stem and progenitor cells isolated from astronauts.

Nature Reviews Molecular Cell Biology, Published online: 05 December 2025; doi:10.1038/s41580-025-00937-xTarget-directed miRNA degradation through interaction with non-coding parts of mRNAs is required for proper mammalian development.

Nature Reviews Molecular Cell Biology, Published online: 04 December 2025; doi:10.1038/s41580-025-00938-wThe transmembrane protein lunpark is enriched at endoplasmic reticulum junctions where it acts as an organization hub, integrating translation initiation control with nutrient sensing through association with lysosomes.

Nature Reviews Molecular Cell Biology, Published online: 04 December 2025; doi:10.1038/s41580-025-00939-9Following skin injury, macrophages infiltrate the adipose tissue, promoting adipocyte lipolysis, and the released fatty acids induce hair regrowth by activating hair follicle stem cells.

Nature Reviews Molecular Cell Biology, Published online: 05 December 2025; doi:10.1038/s41580-025-00937-xTarget-directed miRNA degradation through interaction with non-coding parts of mRNAs is required for proper mammalian development.

Nature Reviews Molecular Cell Biology, Published online: 04 December 2025; doi:10.1038/s41580-025-00938-wThe transmembrane protein lunpark is enriched at endoplasmic reticulum junctions where it acts as an organization hub, integrating translation initiation control with nutrient sensing through association with lysosomes.

Nature Reviews Molecular Cell Biology, Published online: 04 December 2025; doi:10.1038/s41580-025-00939-9Following skin injury, macrophages infiltrate the adipose tissue, promoting adipocyte lipolysis, and the released fatty acids induce hair regrowth by activating hair follicle stem cells.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00934-0In this Comment, Na Sun explores how artificial intelligence-driven methodologies are poised to transform systems biology, particularly in the realm of tissue modelling, and outlines the key challenges that must be overcome to enable the development of truly predictive biological systems.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00921-5The centriole is crucial for fundamental cellular processes in eukaryotes, including cell polarity, signalling and motility. This Review discusses recent insights into the molecular architecture of centrioles and the principles governing their assembly, with a focus on human cells.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00935-zShiri Gur-Cohen discusses a 2007 paper from the Cotsarelis laboratory that reported that new hair follicles can arise de novo in response to wound-induced stress, indicating that in adulthood cells can assume new fate trajectories in response to microenvironmental pressures.

Nature Reviews Molecular Cell Biology, Published online: 26 November 2025; doi:10.1038/s41580-025-00909-1The endosomal sorting complex required for transport machinery supports key cellular functions including cell division, autophagy and membrane repair. This Review presents recent mechanistic and structural insights into the assembly and remodelling of endosomal sorting complex required for transport complexes in different cellular contexts.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00934-0In this Comment, Na Sun explores how artificial intelligence-driven methodologies are poised to transform systems biology, particularly in the realm of tissue modelling, and outlines the key challenges that must be overcome to enable the development of truly predictive biological systems.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00921-5The centriole is crucial for fundamental cellular processes in eukaryotes, including cell polarity, signalling and motility. This Review discusses recent insights into the molecular architecture of centrioles and the principles governing their assembly, with a focus on human cells.

Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00935-zShiri Gur-Cohen discusses a 2007 paper from the Cotsarelis laboratory that reported that new hair follicles can arise de novo in response to wound-induced stress, indicating that in adulthood cells can assume new fate trajectories in response to microenvironmental pressures.

Nature Reviews Molecular Cell Biology, Published online: 26 November 2025; doi:10.1038/s41580-025-00909-1The endosomal sorting complex required for transport machinery supports key cellular functions including cell division, autophagy and membrane repair. This Review presents recent mechanistic and structural insights into the assembly and remodelling of endosomal sorting complex required for transport complexes in different cellular contexts.

Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.

Nature Reviews Molecular Cell Biology, Published online: 18 November 2025; doi:10.1038/s41580-025-00915-3Transcription-blocking DNA lesions lead to transcription stress that is associated with neurodegeneration and accelerated ageing. Recent structural and other findings have clarified how different obstructing lesions are recognized and removed and shed new light on the causes of various pathologies of repair deficiencies.

Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.

Nature Reviews Molecular Cell Biology, Published online: 17 November 2025; doi:10.1038/s41580-025-00931-3In this Tools of the Trade article, Ding (Wang lab) describes the development of tissue expansion-enhanced mass-spectrometry imaging (TEMI), which combines an optimized tissue expansion method with mass spectrometry imaging to obtain multi-omic data at high spatial resolution and is compatible with expansion microscopy.

Nature Reviews Molecular Cell Biology, Published online: 18 November 2025; doi:10.1038/s41580-025-00915-3Transcription-blocking DNA lesions lead to transcription stress that is associated with neurodegeneration and accelerated ageing. Recent structural and other findings have clarified how different obstructing lesions are recognized and removed and shed new light on the causes of various pathologies of repair deficiencies.

Nature Reviews Molecular Cell Biology, Published online: 17 November 2025; doi:10.1038/s41580-025-00931-3In this Tools of the Trade article, Ding (Wang lab) describes the development of tissue expansion-enhanced mass-spectrometry imaging (TEMI), which combines an optimized tissue expansion method with mass spectrometry imaging to obtain multi-omic data at high spatial resolution and is compatible with expansion microscopy.