Mariano F. Zacarías-Fluck
@marianozf.bsky.social
Ph.D. in Biomedical Sciences, Senior Researcher @lsouceklab.bsky.social in Vall d'Hebron Institute of Oncology @VHIO.bsky.social , Barcelona. Amateur musician/genealogist/photographer. #Dataviz lover.
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We are hiring! If you are interested in joining our Models of Cancer Therapy Laboratory lab at @vhio.bsky.social as a Research Laboratory Technician / Lab Manager, apply here: jobs.vhio.net/en/jobs/7018...
2026-002-01 Research Laboratory Technician / Lab Manager - VHIO
Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.
jobs.vhio.net
January 13, 2026 at 11:33 AM
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Reposted by Mariano F. Zacarías-Fluck
We need to talk about salaries in science www.nature.com/articles/d41...
We need to talk about salaries in science
Academia too often has a ‘passion first, money second’ culture. Overcoming this mindset is crucial for building a happy career.
www.nature.com
January 12, 2026 at 3:01 PM
We need to talk about salaries in science www.nature.com/articles/d41...
fantastic work from Fabio Giuntini and @lsoucek.bsky.social and @lsouceklab.bsky.social and a micro-collaboration from myself 😊. @vhio.bsky.social
MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
Giuntini et al. demonstrate that Omomyc, the only direct MYC inhibitor currently in phase 2 clinical trials, causes DNA damage and synergizes with PARPis in triple-negative breast cancer. Their findings provide compelling evidence for clinical exploration of this combination to overcome PARPi resistance.
dlvr.it
January 9, 2026 at 2:07 PM
fantastic work from Fabio Giuntini and @lsoucek.bsky.social and @lsouceklab.bsky.social and a micro-collaboration from myself 😊. @vhio.bsky.social
Reposted by Mariano F. Zacarías-Fluck
You know that thing Coco Chanel said about accessories?
“Before you leave the house, look in the mirror and take one thing off”
We should all do that but with about 50% of the text we put in slide decks.
TAKE. IT. OUT.
“Before you leave the house, look in the mirror and take one thing off”
We should all do that but with about 50% of the text we put in slide decks.
TAKE. IT. OUT.
December 3, 2025 at 7:06 PM
You know that thing Coco Chanel said about accessories?
“Before you leave the house, look in the mirror and take one thing off”
We should all do that but with about 50% of the text we put in slide decks.
TAKE. IT. OUT.
“Before you leave the house, look in the mirror and take one thing off”
We should all do that but with about 50% of the text we put in slide decks.
TAKE. IT. OUT.
Reposted by Mariano F. Zacarías-Fluck
Language models cannot reliably distinguish belief from knowledge and fact www.nature.com/articles/s42...
November 25, 2025 at 9:54 AM
Language models cannot reliably distinguish belief from knowledge and fact www.nature.com/articles/s42...
Reposted by Mariano F. Zacarías-Fluck
Reproducible processing of TCGA regulatory networks academic.oup.com/gigascience/... 🧬🖥️🧪
Reproducible processing of TCGA regulatory networks
AbstractBackground. Technological advances in sequencing and computation have allowed deep exploration of the molecular basis of diseases. Biological netwo
academic.oup.com
October 27, 2025 at 5:55 PM
Reproducible processing of TCGA regulatory networks academic.oup.com/gigascience/... 🧬🖥️🧪
Reposted by Mariano F. Zacarías-Fluck
🔴 Stay tuned‼️ The second call of our VIDA Postdoctoral COFUND Programme opens on Monday 🔜
Funded by a Marie Skłodowska-Curie Actions COFUND Grant, #VHIOVIDAEU is recruiting 8️⃣ postdocs.
👉 https://linke.to/VHIOVIDAprogramme25
#VHIOVIDA #TranslationalResearch #VHIOAcademy
@ec.europa.eu @cerca.cat
Funded by a Marie Skłodowska-Curie Actions COFUND Grant, #VHIOVIDAEU is recruiting 8️⃣ postdocs.
👉 https://linke.to/VHIOVIDAprogramme25
#VHIOVIDA #TranslationalResearch #VHIOAcademy
@ec.europa.eu @cerca.cat
September 12, 2025 at 5:03 PM
🔴 Stay tuned‼️ The second call of our VIDA Postdoctoral COFUND Programme opens on Monday 🔜
Funded by a Marie Skłodowska-Curie Actions COFUND Grant, #VHIOVIDAEU is recruiting 8️⃣ postdocs.
👉 https://linke.to/VHIOVIDAprogramme25
#VHIOVIDA #TranslationalResearch #VHIOAcademy
@ec.europa.eu @cerca.cat
Funded by a Marie Skłodowska-Curie Actions COFUND Grant, #VHIOVIDAEU is recruiting 8️⃣ postdocs.
👉 https://linke.to/VHIOVIDAprogramme25
#VHIOVIDA #TranslationalResearch #VHIOAcademy
@ec.europa.eu @cerca.cat
Reposted by Mariano F. Zacarías-Fluck
I'd say this is a great guide for detecting LLM-generated text anywhere, not just Wikipedia. ⬇️
Wikipedia editors trying to fend off the onslaught of AI crap have crowdsourced some telltale signs of LLM-generated writing; it might be handy for editors and proofreaders generally. Thanks to @ellenrykers.com for pointing me to it. en.wikipedia.org/wiki/Wikiped...
Wikipedia:Signs of AI writing - Wikipedia
en.wikipedia.org
September 1, 2025 at 6:50 AM
I'd say this is a great guide for detecting LLM-generated text anywhere, not just Wikipedia. ⬇️
Reposted by Mariano F. Zacarías-Fluck
I've recently started compiling a list of data science related resources that I use or recommend frequently! 📊
Link: nrennie.rbind.io/data-science...
#RStats #Python #DataViz #DataScience
Link: nrennie.rbind.io/data-science...
#RStats #Python #DataViz #DataScience
October 18, 2024 at 1:58 PM
I've recently started compiling a list of data science related resources that I use or recommend frequently! 📊
Link: nrennie.rbind.io/data-science...
#RStats #Python #DataViz #DataScience
Link: nrennie.rbind.io/data-science...
#RStats #Python #DataViz #DataScience
Reposted by Mariano F. Zacarías-Fluck
We are hiring!
We are searching for a motivated bioinformatics scientist interested in joining our team!
Apply below:
jobs.vhio.net/jobs/6203915...
We are searching for a motivated bioinformatics scientist interested in joining our team!
Apply below:
jobs.vhio.net/jobs/6203915...
2025-040-01 Bioinformatics Scientist - VHIO
Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.
jobs.vhio.net
July 21, 2025 at 10:01 AM
We are hiring!
We are searching for a motivated bioinformatics scientist interested in joining our team!
Apply below:
jobs.vhio.net/jobs/6203915...
We are searching for a motivated bioinformatics scientist interested in joining our team!
Apply below:
jobs.vhio.net/jobs/6203915...
Reposted by Mariano F. Zacarías-Fluck
📣 The 3rd edition of the Master in Health & Science Management is coming 🔜
Don’t miss the opportunity to build your profile as a Scientific Manager and work at high-ranked research institutions through our internship program.
🚨 Enrolment is now open ➡️ https://linke.to/MasterUAB25_VHIO
Don’t miss the opportunity to build your profile as a Scientific Manager and work at high-ranked research institutions through our internship program.
🚨 Enrolment is now open ➡️ https://linke.to/MasterUAB25_VHIO
July 29, 2025 at 12:35 PM
📣 The 3rd edition of the Master in Health & Science Management is coming 🔜
Don’t miss the opportunity to build your profile as a Scientific Manager and work at high-ranked research institutions through our internship program.
🚨 Enrolment is now open ➡️ https://linke.to/MasterUAB25_VHIO
Don’t miss the opportunity to build your profile as a Scientific Manager and work at high-ranked research institutions through our internship program.
🚨 Enrolment is now open ➡️ https://linke.to/MasterUAB25_VHIO
Reposted by Mariano F. Zacarías-Fluck
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
May 15, 2025 at 6:05 PM
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
fantastic news!
🚨🚨 Another lovely and welcome present from Donald #Trump: @ec.europa.eu invests 1,25 BILLION euro in researchers and invites them to choose #Europe for #science. Excellent decision by Commission. #europeforscience ec.europa.eu/commission/p...
Commission invests €1.25 billion in researchers and invites them to ‘Choose Europe for Science\'
Europe is stepping up its ambition to cement the position of a global leader in research. New calls worth over €1.25 billion in 2025 under the Marie Skłodowska-Curie Actions (MSCA) open doors for new ...
ec.europa.eu
May 15, 2025 at 6:15 PM
fantastic news!
Reposted by Mariano F. Zacarías-Fluck
This is another big loss at NIH. He explains why in the thread below.
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
April 16, 2025 at 10:26 PM
This is another big loss at NIH. He explains why in the thread below.
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
Reposted by Mariano F. Zacarías-Fluck
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
April 10, 2025 at 1:38 PM
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
Reposted by Mariano F. Zacarías-Fluck
A saliva test, which analyses men's DNA, could be used in helping to identify those at greater risk of #ProstateCancer, according to a new study led by the ICR's Professor Ros Eeles.
Full story ⬇️
www.icr.ac.uk/about-us/icr...
Full story ⬇️
www.icr.ac.uk/about-us/icr...
April 10, 2025 at 2:57 PM
A saliva test, which analyses men's DNA, could be used in helping to identify those at greater risk of #ProstateCancer, according to a new study led by the ICR's Professor Ros Eeles.
Full story ⬇️
www.icr.ac.uk/about-us/icr...
Full story ⬇️
www.icr.ac.uk/about-us/icr...
Reposted by Mariano F. Zacarías-Fluck
When I convinced the Dutch Science funder to create funding specifically for Replication Studies (www.science.org/content/arti...) I stressed the need to let scientists select the studies to replicate.
And in our paper we point out replications should focus on high impact uncertain results.
And in our paper we point out replications should focus on high impact uncertain results.
Make replication studies ‘a normal and essential part of science,' Dutch science academy says
Scientists, universities, funding agencies, and journals should do more to increase reproducibility, a new report says
www.science.org
March 25, 2025 at 3:57 AM
When I convinced the Dutch Science funder to create funding specifically for Replication Studies (www.science.org/content/arti...) I stressed the need to let scientists select the studies to replicate.
And in our paper we point out replications should focus on high impact uncertain results.
And in our paper we point out replications should focus on high impact uncertain results.
Reposted by Mariano F. Zacarías-Fluck
Was watching Vaiana 2 (or Moana 2 outside of Europe) and the statement by Loto, the engineer character in the movie, is such good advice for early career researchers!
'Perfection's a myth. There is only failing, then learning, then death'.
'Perfection's a myth. There is only failing, then learning, then death'.
March 16, 2025 at 5:47 AM
Was watching Vaiana 2 (or Moana 2 outside of Europe) and the statement by Loto, the engineer character in the movie, is such good advice for early career researchers!
'Perfection's a myth. There is only failing, then learning, then death'.
'Perfection's a myth. There is only failing, then learning, then death'.
Reposted by Mariano F. Zacarías-Fluck
🎙 Nuevo capítulo de #Cancer360 ‼️
🔹 Inteligencia artificial y el uso de datos en la investigación
💬 Adam Martín charla con José Antonio Seoane, Lara Nonell, Francisco Martínez Jiménez y Adrià Marcos.
🎧 👉 https://linke.to/Cancer360IA
#SOMMVHIO
🔹 Inteligencia artificial y el uso de datos en la investigación
💬 Adam Martín charla con José Antonio Seoane, Lara Nonell, Francisco Martínez Jiménez y Adrià Marcos.
🎧 👉 https://linke.to/Cancer360IA
#SOMMVHIO
March 13, 2025 at 4:17 PM
🎙 Nuevo capítulo de #Cancer360 ‼️
🔹 Inteligencia artificial y el uso de datos en la investigación
💬 Adam Martín charla con José Antonio Seoane, Lara Nonell, Francisco Martínez Jiménez y Adrià Marcos.
🎧 👉 https://linke.to/Cancer360IA
#SOMMVHIO
🔹 Inteligencia artificial y el uso de datos en la investigación
💬 Adam Martín charla con José Antonio Seoane, Lara Nonell, Francisco Martínez Jiménez y Adrià Marcos.
🎧 👉 https://linke.to/Cancer360IA
#SOMMVHIO
año 2025, han pasado 41 años y #Microsoft #Word es incapaz de reconocer un cambio de idioma entre párrafos; le entran ataques de pánico y subraya todo en rojo.
#Office es la suite de software más desesperante y probablemente, peor pensada. Pero hegemónica...
#Office es la suite de software más desesperante y probablemente, peor pensada. Pero hegemónica...
March 13, 2025 at 4:53 PM
año 2025, han pasado 41 años y #Microsoft #Word es incapaz de reconocer un cambio de idioma entre párrafos; le entran ataques de pánico y subraya todo en rojo.
#Office es la suite de software más desesperante y probablemente, peor pensada. Pero hegemónica...
#Office es la suite de software más desesperante y probablemente, peor pensada. Pero hegemónica...
Reposted by Mariano F. Zacarías-Fluck
Cancer recurrence predicted by spatial biology of the immune response nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Liver cancer recurrence predicted by immune-cell location and gene expression
Immune cells called natural killer cells can target and eliminate tumours. The gene expression and spatial distribution of the immune cells in the tumour microenvironment indicates whether liver cance...
nature.com
March 12, 2025 at 4:31 PM
Cancer recurrence predicted by spatial biology of the immune response nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Mariano F. Zacarías-Fluck
El @vhio.bsky.social es un centro de investigación del cáncer con una visión integral y reputación internacional.
Ha sido designado por la @ageinves.bsky.social como Centro de Excelencia Severo Ochoa 2020 por lo que se le ha concedido una subvención de 4 M€.
🔗 www.aei.gob.es/ayudas-conce...
Ha sido designado por la @ageinves.bsky.social como Centro de Excelencia Severo Ochoa 2020 por lo que se le ha concedido una subvención de 4 M€.
🔗 www.aei.gob.es/ayudas-conce...
February 27, 2025 at 9:57 AM
El @vhio.bsky.social es un centro de investigación del cáncer con una visión integral y reputación internacional.
Ha sido designado por la @ageinves.bsky.social como Centro de Excelencia Severo Ochoa 2020 por lo que se le ha concedido una subvención de 4 M€.
🔗 www.aei.gob.es/ayudas-conce...
Ha sido designado por la @ageinves.bsky.social como Centro de Excelencia Severo Ochoa 2020 por lo que se le ha concedido una subvención de 4 M€.
🔗 www.aei.gob.es/ayudas-conce...
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Register to attend this talk by immunologist Gabriel Rabinovich, Group Leader at the #CaixaResearchInstitute.
He will walk us through his research journey—from the discovery of galectins to their clinical applications.
📅 March 12—18:30
📍 CosmoCaixa
🎟 Registration link: lnkd.in/epCGcc_3
He will walk us through his research journey—from the discovery of galectins to their clinical applications.
📅 March 12—18:30
📍 CosmoCaixa
🎟 Registration link: lnkd.in/epCGcc_3
February 25, 2025 at 12:16 PM
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