Katreya Lovrenert
@katreya.bsky.social
Computational Biology Manager for the Institute for Glial Sciences at Case Western Reserve University
Reposted by Katreya Lovrenert
Psilocybin reshapes how the brain is connected. 🧠⚡️
Using viral tracing methods, the study found the psychedelic strengthens pathways related to sensory processing and weakened those tied to rumination.
@thetransmitter.bsky.social dives deeper into the study: https://bit.ly/4aD13AS
#neuroskyence
Using viral tracing methods, the study found the psychedelic strengthens pathways related to sensory processing and weakened those tied to rumination.
@thetransmitter.bsky.social dives deeper into the study: https://bit.ly/4aD13AS
#neuroskyence
December 9, 2025 at 5:00 PM
Psilocybin reshapes how the brain is connected. 🧠⚡️
Using viral tracing methods, the study found the psychedelic strengthens pathways related to sensory processing and weakened those tied to rumination.
@thetransmitter.bsky.social dives deeper into the study: https://bit.ly/4aD13AS
#neuroskyence
Using viral tracing methods, the study found the psychedelic strengthens pathways related to sensory processing and weakened those tied to rumination.
@thetransmitter.bsky.social dives deeper into the study: https://bit.ly/4aD13AS
#neuroskyence
Reposted by Katreya Lovrenert
tidyomics project 🔛 R-bloggers!
www.r-bloggers.com/2025/10/the-...
Thanks to @stemang.bsky.social, Maria Doyle @bioconductor.bsky.social, @jhsanchez.bsky.social, Mengyuan Shen, Jonathan Carroll and others in tidyomics for testing and getting this up and running
www.r-bloggers.com/2025/10/the-...
Thanks to @stemang.bsky.social, Maria Doyle @bioconductor.bsky.social, @jhsanchez.bsky.social, Mengyuan Shen, Jonathan Carroll and others in tidyomics for testing and getting this up and running
December 8, 2025 at 5:28 PM
tidyomics project 🔛 R-bloggers!
www.r-bloggers.com/2025/10/the-...
Thanks to @stemang.bsky.social, Maria Doyle @bioconductor.bsky.social, @jhsanchez.bsky.social, Mengyuan Shen, Jonathan Carroll and others in tidyomics for testing and getting this up and running
www.r-bloggers.com/2025/10/the-...
Thanks to @stemang.bsky.social, Maria Doyle @bioconductor.bsky.social, @jhsanchez.bsky.social, Mengyuan Shen, Jonathan Carroll and others in tidyomics for testing and getting this up and running
Reposted by Katreya Lovrenert
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted by Katreya Lovrenert
you know how i know im a 44yo dad? how much i laughed at this shit
December 6, 2025 at 3:31 AM
you know how i know im a 44yo dad? how much i laughed at this shit
Reposted by Katreya Lovrenert
We got Weird Al out here singing Killing In The Name, the time for moderation is over
December 6, 2025 at 2:45 PM
We got Weird Al out here singing Killing In The Name, the time for moderation is over
Reposted by Katreya Lovrenert
AAAAAAAAAAAAAAAHHHHHHHHHHHHHH
December 5, 2025 at 12:47 AM
AAAAAAAAAAAAAAAHHHHHHHHHHHHHH
Reposted by Katreya Lovrenert
Reposted by Katreya Lovrenert
It's with heavy hearts that we share that Claude, our beloved albino alligator, has passed away at the age of 30. Claude brought joy to millions of people at the Academy and across the world during his 17 year tenure. We will miss him dearly. 🤍
December 2, 2025 at 10:22 PM
It's with heavy hearts that we share that Claude, our beloved albino alligator, has passed away at the age of 30. Claude brought joy to millions of people at the Academy and across the world during his 17 year tenure. We will miss him dearly. 🤍
Reposted by Katreya Lovrenert
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 2, 2025 at 2:28 AM
Reposted by Katreya Lovrenert
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by Katreya Lovrenert
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...
www.science.org
November 27, 2025 at 7:10 PM
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Reposted by Katreya Lovrenert
This is Bear. He is in charge of supervising Thanksgiving dinner preparation. Appointed himself to the role, but takes it very seriously. 14/10 (TT: emileebellant)
November 27, 2025 at 5:25 PM
This is Bear. He is in charge of supervising Thanksgiving dinner preparation. Appointed himself to the role, but takes it very seriously. 14/10 (TT: emileebellant)
Reposted by Katreya Lovrenert
Frog and Toad ate many cookies, one after another.
“You know, Toad,” said Frog, with his mouth full, “I think we should stop eating. We will soon be sick.”
“You are right,” said Toad. “Let us eat one last cookie, and then we will stop.”
“You know, Toad,” said Frog, with his mouth full, “I think we should stop eating. We will soon be sick.”
“You are right,” said Toad. “Let us eat one last cookie, and then we will stop.”
November 27, 2025 at 5:37 AM
Frog and Toad ate many cookies, one after another.
“You know, Toad,” said Frog, with his mouth full, “I think we should stop eating. We will soon be sick.”
“You are right,” said Toad. “Let us eat one last cookie, and then we will stop.”
“You know, Toad,” said Frog, with his mouth full, “I think we should stop eating. We will soon be sick.”
“You are right,” said Toad. “Let us eat one last cookie, and then we will stop.”
Reposted by Katreya Lovrenert
Reposted by Katreya Lovrenert
1/ Public datasets feel like a goldmine.
But look closer—there are landmines hidden inside.
Especially for single-cell RNA-seq.
A thread 🧵
But look closer—there are landmines hidden inside.
Especially for single-cell RNA-seq.
A thread 🧵
November 27, 2025 at 2:15 PM
1/ Public datasets feel like a goldmine.
But look closer—there are landmines hidden inside.
Especially for single-cell RNA-seq.
A thread 🧵
But look closer—there are landmines hidden inside.
Especially for single-cell RNA-seq.
A thread 🧵
Reposted by Katreya Lovrenert
1/ One of the biggest hidden killer in bioinformatics?
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
November 27, 2025 at 2:45 PM
1/ One of the biggest hidden killer in bioinformatics?
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
Reposted by Katreya Lovrenert
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 26, 2025 at 11:15 AM
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
Reposted by Katreya Lovrenert
We are excited to share our online book and preprint on “Orchestrating Spatial Transcriptomics Analysis with Bioconductor”!
Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA.
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
November 22, 2025 at 12:38 PM
We are excited to share our online book and preprint on “Orchestrating Spatial Transcriptomics Analysis with Bioconductor”!
Reposted by Katreya Lovrenert
me: ok six weeks left of 2025 let's get stuff done!
my brain cells:
my brain cells:
November 13, 2025 at 8:56 PM
me: ok six weeks left of 2025 let's get stuff done!
my brain cells:
my brain cells:
Reposted by Katreya Lovrenert
Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.
CRISPR Behaves Differently in the Brain Than Anywhere Else
A new study shows that neurons repair CRISPR-Cas9 cuts in unique, highly predictable ways, unlike dividing cells. Researchers found Cas9 persists far longer in neurons and triggers unexpected repair p...
www.technologynetworks.com
November 24, 2025 at 6:05 PM
Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.
Reposted by Katreya Lovrenert
I was loving Claude Code... until I tried it with #rstats. Constant errors, wouldn't use the tidyverse even when asked, "optimized" functions were slower.
Frustrated, I started a session just to teach R to Claude and summarize what it learned into a CLAUDE.md file gist.github.com/sj-io/3828d6...
Frustrated, I started a session just to teach R to Claude and summarize what it learned into a CLAUDE.md file gist.github.com/sj-io/3828d6...
Claude R Tidyverse Expert
Claude R Tidyverse Expert. GitHub Gist: instantly share code, notes, and snippets.
gist.github.com
August 21, 2025 at 10:18 AM
I was loving Claude Code... until I tried it with #rstats. Constant errors, wouldn't use the tidyverse even when asked, "optimized" functions were slower.
Frustrated, I started a session just to teach R to Claude and summarize what it learned into a CLAUDE.md file gist.github.com/sj-io/3828d6...
Frustrated, I started a session just to teach R to Claude and summarize what it learned into a CLAUDE.md file gist.github.com/sj-io/3828d6...
Reposted by Katreya Lovrenert
cleveland.thanksgivingheroes.org/flower-enter...
Please help families get Thanksgiving dinner this year. thank you. #Thanksgiving
Please help families get Thanksgiving dinner this year. thank you. #Thanksgiving
Flower Entertainment Inc's Virtual Drive - Thanksgiving Heroes Cleveland
Welcome to Flower Entertainment Inc's Virtual Turkey Drive At FEI, we are deeply committed to making a difference in our community, especially during the holiday season. This year, we are excited to p...
cleveland.thanksgivingheroes.org
November 18, 2025 at 8:24 PM
cleveland.thanksgivingheroes.org/flower-enter...
Please help families get Thanksgiving dinner this year. thank you. #Thanksgiving
Please help families get Thanksgiving dinner this year. thank you. #Thanksgiving
Reposted by Katreya Lovrenert
Reposted by Katreya Lovrenert
What happens when you combine 10 years of brain data with one of the world’s fastest supercomputers?
A virtual mouse cortex simulation, thanks to a global collaboration.
🧠📈 https://alleninstitute.org/news/one-of-worlds-most-detailed-virtual-brain-simulations-is-changing-how-we-study-the-brain/
A virtual mouse cortex simulation, thanks to a global collaboration.
🧠📈 https://alleninstitute.org/news/one-of-worlds-most-detailed-virtual-brain-simulations-is-changing-how-we-study-the-brain/
November 17, 2025 at 7:26 PM
What happens when you combine 10 years of brain data with one of the world’s fastest supercomputers?
A virtual mouse cortex simulation, thanks to a global collaboration.
🧠📈 https://alleninstitute.org/news/one-of-worlds-most-detailed-virtual-brain-simulations-is-changing-how-we-study-the-brain/
A virtual mouse cortex simulation, thanks to a global collaboration.
🧠📈 https://alleninstitute.org/news/one-of-worlds-most-detailed-virtual-brain-simulations-is-changing-how-we-study-the-brain/
Reposted by Katreya Lovrenert
What if inflammation doesn’t just bring in immune cells, but changes the entire neighborhood?
Our new preprint led by brilliant MD/PhD student @kateletai.bsky.social in collaboration with the Cominelli lab and @biancaislam.bsky.social explores this question:
www.biorxiv.org/content/10.1...
Our new preprint led by brilliant MD/PhD student @kateletai.bsky.social in collaboration with the Cominelli lab and @biancaislam.bsky.social explores this question:
www.biorxiv.org/content/10.1...
Epithelial and stromal remodeling in murine Crohn’s disease-like ileitis
Background and Aims Inflammatory bowel disease is characterized by progressive epithelial, immune, and stromal dysfunction. Human datasets yield important insights yet are inherently descriptive, requ...
www.biorxiv.org
November 13, 2025 at 1:53 AM
What if inflammation doesn’t just bring in immune cells, but changes the entire neighborhood?
Our new preprint led by brilliant MD/PhD student @kateletai.bsky.social in collaboration with the Cominelli lab and @biancaislam.bsky.social explores this question:
www.biorxiv.org/content/10.1...
Our new preprint led by brilliant MD/PhD student @kateletai.bsky.social in collaboration with the Cominelli lab and @biancaislam.bsky.social explores this question:
www.biorxiv.org/content/10.1...