Gladstone Institutes
@gladstoneinst.bsky.social
To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
Bruce Conklin and his team demonstrate that manipulating DNA repair pathways in nondividing cells can direct outcomes and improve efficiency of #CRISPR genome editing.
News: Neurons repair CRISPR damage with unique timing - CRISPR Medicine
Neurons show slow and distinct DNA repair responses after CRISPR editing, challenging assumptions based on dividing cells. Researchers demonstrate that manipulating these repair pathways in nondividing cells can direct outcomes and improve editing effic...
bit.ly
November 29, 2025 at 8:49 PM
Bruce Conklin and his team demonstrate that manipulating DNA repair pathways in nondividing cells can direct outcomes and improve efficiency of #CRISPR genome editing.
Scientists at Gladstone and @ucsanfrancisco.bsky.social have discovered a new way to outsmart COVID-19. Their study reveals that the molecule AVI-4206 blocks a key viral protein called Mac1—stopping the virus from hiding from our immune system.
@theottlab.bsky.social
https://bit.ly/3Xi6ldm
@theottlab.bsky.social
https://bit.ly/3Xi6ldm
YouTube
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November 28, 2025 at 9:13 PM
Scientists at Gladstone and @ucsanfrancisco.bsky.social have discovered a new way to outsmart COVID-19. Their study reveals that the molecule AVI-4206 blocks a key viral protein called Mac1—stopping the virus from hiding from our immune system.
@theottlab.bsky.social
https://bit.ly/3Xi6ldm
@theottlab.bsky.social
https://bit.ly/3Xi6ldm
🧡🍁 Happy Thanksgiving from Gladstone! 🧡🍁
We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.
We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.
November 27, 2025 at 4:09 PM
🧡🍁 Happy Thanksgiving from Gladstone! 🧡🍁
We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.
We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.
Scientists from Alex Marson’s lab have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.
Regulating this gene is essential to immune system balance
Researchers have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.
www.biotechniques.com
November 26, 2025 at 5:13 PM
Scientists from Alex Marson’s lab have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
Read more about this new study on our website: https://bit.ly/4nUtpcT
Read more about this new study on our website: https://bit.ly/4nUtpcT
November 26, 2025 at 3:55 PM
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
Read more about this new study on our website: https://bit.ly/4nUtpcT
Read more about this new study on our website: https://bit.ly/4nUtpcT
In honor of World AIDS Day, take an inside look at an HIV cure research lab to meet the scientists bringing us closer to ending HIV.
Join the live tour on TikTok on December 1.
Join the live tour on TikTok on December 1.
HIV Cure Lab Tour + Q&A | LIVE Event
2 people registered for this event. See what's going on there!
bit.ly
November 25, 2025 at 6:15 PM
In honor of World AIDS Day, take an inside look at an HIV cure research lab to meet the scientists bringing us closer to ending HIV.
Join the live tour on TikTok on December 1.
Join the live tour on TikTok on December 1.
Reposted by Gladstone Institutes
What does the fox say? 🦊 Dr. Alex Marson (@marsonlab.bsky.social) and scientists have the answer! Using CRISPR-based gene silencing technology, they mapped the network of genetic switches that immune cells use to fine-tune FOXP3 levels.
@gladstoneinst.bsky.social @ucsanfrancisco.bsky.social
@gladstoneinst.bsky.social @ucsanfrancisco.bsky.social
Researchers Reveal Intricate Control System for Key Immune Gene
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
gladstone.org
November 21, 2025 at 4:10 PM
What does the fox say? 🦊 Dr. Alex Marson (@marsonlab.bsky.social) and scientists have the answer! Using CRISPR-based gene silencing technology, they mapped the network of genetic switches that immune cells use to fine-tune FOXP3 levels.
@gladstoneinst.bsky.social @ucsanfrancisco.bsky.social
@gladstoneinst.bsky.social @ucsanfrancisco.bsky.social
Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.
CRISPR Behaves Differently in the Brain Than Anywhere Else
A new study shows that neurons repair CRISPR-Cas9 cuts in unique, highly predictable ways, unlike dividing cells. Researchers found Cas9 persists far longer in neurons and triggers unexpected repair p...
www.technologynetworks.com
November 24, 2025 at 6:05 PM
Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.
Exciting news! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize on December 1.
Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬
Register: https://bit.ly/4gNhf3z
Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬
Register: https://bit.ly/4gNhf3z
November 24, 2025 at 4:49 PM
Exciting news! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize on December 1.
Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬
Register: https://bit.ly/4gNhf3z
Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬
Register: https://bit.ly/4gNhf3z
In our November newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for the 2025 Ogawa-Yamanaka Stem Cell Prize Award Ceremony.
https://bit.ly/44jCdC7
https://bit.ly/44jCdC7
Cell Signals〡The Genome Editing Playbook Is Different in Neurons
In today’s newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for ...
bit.ly
November 23, 2025 at 6:43 PM
In our November newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for the 2025 Ogawa-Yamanaka Stem Cell Prize Award Ceremony.
https://bit.ly/44jCdC7
https://bit.ly/44jCdC7
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
https://bit.ly/4oc6dXU
https://bit.ly/4oc6dXU
YouTube
Share your videos with friends, family, and the world
bit.ly
November 22, 2025 at 8:51 PM
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
https://bit.ly/4oc6dXU
https://bit.ly/4oc6dXU
From her home on Potrero Hill to her lab just a few blocks away, Katie Pollard is using AI to teach computers how to read DNA — with the goal of predicting disease risk long before symptoms show up.
Cracking the Code of Life from the Top of Potrero Hill - Potrero View
Most mornings, Katie Pollard walks from her Connecticut Street home to her Owens Street laboratory; a pleasant commute that bridges two worlds. At one end, neighbors chat over coffee, plan movie night...
www.potreroview.net
November 21, 2025 at 9:19 PM
From her home on Potrero Hill to her lab just a few blocks away, Katie Pollard is using AI to teach computers how to read DNA — with the goal of predicting disease risk long before symptoms show up.
🚨 🚨 NEW STUDY 🚨 🚨 "CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology"
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.
bit.ly
November 21, 2025 at 6:55 PM
🚨 🚨 NEW STUDY 🚨 🚨 "CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology"
Reposted by Gladstone Institutes
New from IGI's @bruceconklin.bsky.social!
🚨 NEW PUBLICATION 🚨 "Characterizing and controlling #CRISPR repair outcomes in nondividing human cells"
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
Characterizing and controlling CRISPR repair outcomes in nondividing human cells - Nature Communications
Genome editing tools can precisely introduce a specified lesion into the DNA, but ultimately rely on the cell’s DNA repair machinery to determine the editing outcome. Here, authors demonstrate how neu...
www.nature.com
November 19, 2025 at 5:22 PM
New from IGI's @bruceconklin.bsky.social!
Lennart Mucke reflects on how Alzheimer’s research has evolved since the founding of the Gladstone Institute of Neurological Disease.
#AlzheimersAwarenessMonth
#AlzheimersAwarenessMonth
November 20, 2025 at 4:52 PM
Lennart Mucke reflects on how Alzheimer’s research has evolved since the founding of the Gladstone Institute of Neurological Disease.
#AlzheimersAwarenessMonth
#AlzheimersAwarenessMonth
New research from the Gladstone reveals that the mitochondrial protein CHCHD2 may play a key role in triggering Parkinson’s disease, highlighting a new direction in understanding how the disease begins.
Late-Onset Parkinson's Linked to Mitochondrial Protein CHCHD2
The mitochondrial protein CHCHD2 can drive a sequence of cellular events that lead to the development Parkinson’s disease (PD).
bit.ly
November 20, 2025 at 3:48 PM
New research from the Gladstone reveals that the mitochondrial protein CHCHD2 may play a key role in triggering Parkinson’s disease, highlighting a new direction in understanding how the disease begins.
🚨 NEW PUBLICATION 🚨 "Characterizing and controlling #CRISPR repair outcomes in nondividing human cells"
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
Characterizing and controlling CRISPR repair outcomes in nondividing human cells - Nature Communications
Genome editing tools can precisely introduce a specified lesion into the DNA, but ultimately rely on the cell’s DNA repair machinery to determine the editing outcome. Here, authors demonstrate how neu...
www.nature.com
November 19, 2025 at 5:13 PM
🚨 NEW PUBLICATION 🚨 "Characterizing and controlling #CRISPR repair outcomes in nondividing human cells"
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
@natcomms.nature.com
@ucberkeleyofficial.bsky.social
@ucsanfrancisco.bsky.social
@innovativegenomics.bsky.social
https://go.nature.com/4plheqJ
Reposted by Gladstone Institutes
Characterizing and controlling CRISPR repair outcomes in nondividing human cells @natcomms.nature.com @gladstoneinst.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 18, 2025 at 6:07 PM
Characterizing and controlling CRISPR repair outcomes in nondividing human cells @natcomms.nature.com @gladstoneinst.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The secret to Gladstone’s impact? A tight-knit community of top scientists, a laser focus on disease, and partnerships that stretch around the world.
Dive in at gladstonenow.org.
Dive in at gladstonenow.org.
November 18, 2025 at 6:11 PM
The secret to Gladstone’s impact? A tight-knit community of top scientists, a laser focus on disease, and partnerships that stretch around the world.
Dive in at gladstonenow.org.
Dive in at gladstonenow.org.
Gladstone Investigator Ken Nakamura led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment.
Evidence Builds for Disrupted Mitochondria as Cause of Parkinson's
A new study from Gladstone Institutes strengthens the links between energy breakdown in cells and the onset of Parkinson's, potentially illuminating new paths for treatment.
gladstone.org
November 18, 2025 at 5:36 PM
Gladstone Investigator Ken Nakamura led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment.
A new study by scientists from Gladstone, Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases.
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
The Genome Editing Playbook Is Different in Neurons
The striking findings of a new study could influence how gene therapies are designed for many genetic diseases.
gladstone.org
November 17, 2025 at 8:51 PM
A new study by scientists from Gladstone, Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases.
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
Reposted by Gladstone Institutes
FOXP3—identified decades ago in work that won this year's @nobelprize.org—prevents autoimmune disease.
Now @marsonlab.bsky.social & colleagues at @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social have mapped how immune cells fine-tune FOXP3 levels. gladstone.org/news/researc...
Now @marsonlab.bsky.social & colleagues at @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social have mapped how immune cells fine-tune FOXP3 levels. gladstone.org/news/researc...
Researchers Reveal Intricate Control System for Key Immune Gene
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
gladstone.org
November 14, 2025 at 7:10 PM
FOXP3—identified decades ago in work that won this year's @nobelprize.org—prevents autoimmune disease.
Now @marsonlab.bsky.social & colleagues at @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social have mapped how immune cells fine-tune FOXP3 levels. gladstone.org/news/researc...
Now @marsonlab.bsky.social & colleagues at @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social have mapped how immune cells fine-tune FOXP3 levels. gladstone.org/news/researc...
Reposted by Gladstone Institutes
New from IGI's @marsonlab.bsky.social!
🚨NEW PUBLICATION 🚨 "FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry"
@cp-immunity.bsky.social
@ucsanfrancisco.bsky.social
@parkerici.bsky.social
@innovativegenomics.bsky.social
@arcinstitute.org
https://bit.ly/4paigFO
@cp-immunity.bsky.social
@ucsanfrancisco.bsky.social
@parkerici.bsky.social
@innovativegenomics.bsky.social
@arcinstitute.org
https://bit.ly/4paigFO
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
FOXP3 is a transcription factor critical for immune homeostasis. Using a broad CRISPR
toolkit, Umhoefer et al. elucidate the cis- and trans-regulatory circuitry governing
FOXP3 expression in human Tre...
www.cell.com
November 14, 2025 at 8:34 PM
New from IGI's @marsonlab.bsky.social!
Researchers from Gladstone were part of a team that discovered a way to efficiently deliver therapeutic messenger RNA into heart muscle cells.
Heart-on-a-chip may lead to new treatments for heart failure - Berkeley Engineering
Model helps identify nanoparticles that can deliver mRNA directly into heart muscle cells
bit.ly
November 16, 2025 at 6:42 PM
Researchers from Gladstone were part of a team that discovered a way to efficiently deliver therapeutic messenger RNA into heart muscle cells.
Discover how Gladstone scientists combined stem cells, gene editing, and AI to uncover a gene linked to heart defects in Down syndrome—and restored normal heart development in mice, opening doors to new treatments.
Science in Seconds | Researchers Pinpoint Key Gene Behind Heart Defects in Down Syndrome
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome--and how reducing its levels in mice restored normal heart development, offering hope for future treatments
bit.ly
November 15, 2025 at 8:52 PM
Discover how Gladstone scientists combined stem cells, gene editing, and AI to uncover a gene linked to heart defects in Down syndrome—and restored normal heart development in mice, opening doors to new treatments.