Joshua Frenster
@joshifrenster.bsky.social
Cell competition in development/gastruloids (postdoc Alfonso Martinez Arias lab)
Previously: adhesion GPCRs in Glioblastoma (PhD Placantonakis Lab NYU)
Previously: adhesion GPCRs in Glioblastoma (PhD Placantonakis Lab NYU)
Pinned
Let's get the discussion rolling with a starter pack that will grow over time!
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
Reposted by Joshua Frenster
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
September 25, 2025 at 2:17 PM
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
Reposted by Joshua Frenster
Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
July 8, 2025 at 10:54 AM
Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
Reposted by Joshua Frenster
Save the date 📅! Our TriNational #devbio #stemcell Meeting 2025 will be held in Freiburg on Sept. 19th. As always, participation is free and talks will be selected from early career scientists. Joun us 😊
Info: devstemcell.org/home
@biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social
Info: devstemcell.org/home
@biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social
June 16, 2025 at 6:44 AM
Save the date 📅! Our TriNational #devbio #stemcell Meeting 2025 will be held in Freiburg on Sept. 19th. As always, participation is free and talks will be selected from early career scientists. Joun us 😊
Info: devstemcell.org/home
@biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social
Info: devstemcell.org/home
@biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social
Big news! "researchers will be eligible to apply for a Starting Grant immediately after successfully defending their PhD, and at any time within the following ten-year period." #ERC #ERCstarting
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
erc.europa.eu
June 4, 2025 at 8:59 AM
Big news! "researchers will be eligible to apply for a Starting Grant immediately after successfully defending their PhD, and at any time within the following ten-year period." #ERC #ERCstarting
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Reposted by Joshua Frenster
I'm excited to join @pritiagarwal.bsky.social and @tarafinegan.bsky.social as a co-organizer for the International Developmental Mechanics Seminar Series. The series will resume in September 2025, and call for speakers is now open! More info is on our new website: sites.google.com/view/devmech...
May 9, 2025 at 3:06 AM
I'm excited to join @pritiagarwal.bsky.social and @tarafinegan.bsky.social as a co-organizer for the International Developmental Mechanics Seminar Series. The series will resume in September 2025, and call for speakers is now open! More info is on our new website: sites.google.com/view/devmech...
Reposted by Joshua Frenster
📢 Fresh off the press and featuring new exciting experiments! 🧪
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊
doi.org/10.1016/j.st...
B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊
doi.org/10.1016/j.st...
B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩
April 16, 2025 at 5:40 PM
📢 Fresh off the press and featuring new exciting experiments! 🧪
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊
doi.org/10.1016/j.st...
B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊
doi.org/10.1016/j.st...
B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩
I'm really grateful for the large turnout of our Gastruloid meeting in Barcelona. Close to 100 researchers from 9 countries. With the gastruloid field expanding, I hope that the community stays this close and that the meeting becomes an annual tradition! #gastruloids #conference
March 23, 2025 at 5:04 PM
I'm really grateful for the large turnout of our Gastruloid meeting in Barcelona. Close to 100 researchers from 9 countries. With the gastruloid field expanding, I hope that the community stays this close and that the meeting becomes an annual tradition! #gastruloids #conference
Reposted by Joshua Frenster
The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.
March 21, 2025 at 10:03 PM
The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.
Reposted by Joshua Frenster
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
March 20, 2025 at 12:13 PM
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference
March 20, 2025 at 2:45 PM
First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference
Reposted by Joshua Frenster
Excited to share our latest paper in DevCell! We show how EOMES and the SWI/SNF complex collaborate to drive chromatin remodeling, establishing mesoderm and endoderm differentiation potential.
Read the full paper here: www.cell.com/developmenta...
Read the full paper here: www.cell.com/developmenta...
EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together
with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility
at mesoderm and endoderm (ME...
www.cell.com
March 13, 2025 at 2:07 PM
Excited to share our latest paper in DevCell! We show how EOMES and the SWI/SNF complex collaborate to drive chromatin remodeling, establishing mesoderm and endoderm differentiation potential.
Read the full paper here: www.cell.com/developmenta...
Read the full paper here: www.cell.com/developmenta...
Reposted by Joshua Frenster
Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response
SIRF: Sergio Acebron @acebronsp.bsky.social @cosheidelberg.bsky.social and colleagues develop a new #biosensor reporting on functional interactions between dsDNA sensor STING and #IRF3, allowing to capture STING activation upon various triggers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 26, 2025 at 7:44 AM
Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response
Thinking about the Spanish word "anoche", I realized that we forgot the English word "yestereve". Bring back concise words!
January 30, 2025 at 6:25 PM
Thinking about the Spanish word "anoche", I realized that we forgot the English word "yestereve". Bring back concise words!
Reposted by Joshua Frenster
1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵
January 26, 2025 at 4:36 PM
1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵
Reposted by Joshua Frenster
www.biorxiv.org/content/10.1...
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.
A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian body plan
Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation and primitive streak formation. While the literature suggests that ...
www.biorxiv.org
January 13, 2025 at 11:36 AM
www.biorxiv.org/content/10.1...
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.
Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.
Reposted by Joshua Frenster
We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis
#IInNumbersWeTrust #NotInTheGenes
#IInNumbersWeTrust #NotInTheGenes
December 17, 2024 at 6:52 PM
We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis
#IInNumbersWeTrust #NotInTheGenes
#IInNumbersWeTrust #NotInTheGenes
Reposted by Joshua Frenster
For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...
Please RT !!
research.pasteur.fr/fr/call/call...
Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur
research.pasteur.fr
December 8, 2024 at 9:54 PM
For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...
Please RT !!
research.pasteur.fr/fr/call/call...
When late science-nights reward you with those types of views, it makes it all worth it!
December 4, 2024 at 10:04 PM
When late science-nights reward you with those types of views, it makes it all worth it!
Reposted by Joshua Frenster
Next week, we’re back with two unique development talks: mouse gastruloids 🐭 with Kristina Stapornwongkul and turtles 🐢 with Agáta Horáčková & Barbora Straková. Mark your calendar—you won’t want to miss this!
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
November 28, 2024 at 1:22 AM
Next week, we’re back with two unique development talks: mouse gastruloids 🐭 with Kristina Stapornwongkul and turtles 🐢 with Agáta Horáčková & Barbora Straková. Mark your calendar—you won’t want to miss this!
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
Reposted by Joshua Frenster
We recently uncovered that morphogenetic signals not only read our blueprints, but are key to maintain them, particularly in stem cells. Joint effort of numerous collaborations and the lead of Prof. Sergio Acebrón at @cosheidelberg.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress - Nature Communications
Here the authors show that the patterning signals WNT, BMP, and FGF control chromosome segregation fidelity during early lineage specification and neurogenesis, which could provide a rationale for the...
www.nature.com
November 25, 2024 at 9:42 PM
We recently uncovered that morphogenetic signals not only read our blueprints, but are key to maintain them, particularly in stem cells. Joint effort of numerous collaborations and the lead of Prof. Sergio Acebrón at @cosheidelberg.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joshua Frenster
i'm begging y'all to stop reporting centrifuge speeds in RPM. plz stop.
November 14, 2024 at 6:18 PM
i'm begging y'all to stop reporting centrifuge speeds in RPM. plz stop.
Let's get the discussion rolling with a starter pack that will grow over time!
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
November 20, 2024 at 5:45 PM
Let's get the discussion rolling with a starter pack that will grow over time!
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
go.bsky.app/JyvbmXA
#gastruloid #stembryo #gastruloids
🚨 The Gastruloid Meeting will take place in Barcelona, Spain on March 20-21st 2025. Registration will be free but mandatory. Please let us know if you plan on attending, using this link:
forms.gle/EtHZukwqgyN6...
(Pre-registration is closing soon)
Spread the word! #gastruloid #conference
forms.gle/EtHZukwqgyN6...
(Pre-registration is closing soon)
Spread the word! #gastruloid #conference
Gastruloid meeting Barcelona 20-21.03.2025
Dear all,
The lab of Alfonso Martinez Arias is organizing a gastruloid meeting at the Barcelona Biomedical Research Park (PRBB), in Barcelona (Spain), on March 20th-21st, 2025 (Thursday afternoon and...
forms.gle
November 20, 2024 at 9:07 AM
🚨 The Gastruloid Meeting will take place in Barcelona, Spain on March 20-21st 2025. Registration will be free but mandatory. Please let us know if you plan on attending, using this link:
forms.gle/EtHZukwqgyN6...
(Pre-registration is closing soon)
Spread the word! #gastruloid #conference
forms.gle/EtHZukwqgyN6...
(Pre-registration is closing soon)
Spread the word! #gastruloid #conference