Jase Gehring
@skyjase.bsky.social
scientist at UC Berkeley inventing advanced genomic technologies
lover of molecules, user of computers
https://scholar.google.com/citations?user=63ZRebIAAAAJ&hl=en
lover of molecules, user of computers
https://scholar.google.com/citations?user=63ZRebIAAAAJ&hl=en
these podcasts gettin real cavalier with the ads. we got the ad burden of a primetime football game with the production value of a quarterly earnings call
November 27, 2025 at 7:38 PM
these podcasts gettin real cavalier with the ads. we got the ad burden of a primetime football game with the production value of a quarterly earnings call
Give em giant fokkin solar sails. stick lil nuclear reactors in em. Mobile floating fokkin power plants that charge up the port when they dock
‘The narwhals stop calling’: how the noise from ships is silencing wildlife in the Arctic #Canada
Evidence that the whales and other marine animals are particularly vulnerable to sound is driving calls for quieter vessels
www.theguardian.com/environment/...
Evidence that the whales and other marine animals are particularly vulnerable to sound is driving calls for quieter vessels
www.theguardian.com/environment/...
‘The narwhals stop calling’: how the noise from ships is silencing wildlife in the Arctic
Evidence that the whales and other marine animals are particularly vulnerable to sound is driving calls for quieter vessels
www.theguardian.com
November 27, 2025 at 5:24 PM
Give em giant fokkin solar sails. stick lil nuclear reactors in em. Mobile floating fokkin power plants that charge up the port when they dock
Reposted by Jase Gehring
we got boomer chimps now?
November 27, 2025 at 2:11 PM
we got boomer chimps now?
ok i'm a lil insomniacky so i'll play
@fabiankloltz on the BRCA2 gene cycle path connecting the Addenbrookes Biomedical campus to the @wellcometrust.bsky.social Hinton campus in Cambridge UK.
November 27, 2025 at 12:01 PM
ok i'm a lil insomniacky so i'll play
plasma bonding PDMS/glass. also running a bunch of silanizations. aurora in a box never gets old
November 26, 2025 at 11:58 PM
plasma bonding PDMS/glass. also running a bunch of silanizations. aurora in a box never gets old
trying out a new-to-me chip design today. my depth perception is abysmal
November 26, 2025 at 7:25 PM
trying out a new-to-me chip design today. my depth perception is abysmal
I once tried to build on some results from an RSC journal. a microfluidic cell concentrator that was published without device designs (!🚩🚩!)
Contacted the authors and they were like ya it doesn’t really work, wouldn’t recommend building it. Now you tell me!
Contacted the authors and they were like ya it doesn’t really work, wouldn’t recommend building it. Now you tell me!
I’ll also add, anecdotally, their papers often lack sufficient supplementary materials. Good place to drop off some junk if you’re just looking for a line on the CV
royal society of chemistry (RSC) has been and continues to be one of the worst outlets for science. consistently difficult to access papers. i cringe when i land on their webpage.
November 26, 2025 at 4:53 PM
I once tried to build on some results from an RSC journal. a microfluidic cell concentrator that was published without device designs (!🚩🚩!)
Contacted the authors and they were like ya it doesn’t really work, wouldn’t recommend building it. Now you tell me!
Contacted the authors and they were like ya it doesn’t really work, wouldn’t recommend building it. Now you tell me!
I’ll also add, anecdotally, their papers often lack sufficient supplementary materials. Good place to drop off some junk if you’re just looking for a line on the CV
royal society of chemistry (RSC) has been and continues to be one of the worst outlets for science. consistently difficult to access papers. i cringe when i land on their webpage.
November 26, 2025 at 4:48 PM
I’ll also add, anecdotally, their papers often lack sufficient supplementary materials. Good place to drop off some junk if you’re just looking for a line on the CV
royal society of chemistry (RSC) has been and continues to be one of the worst outlets for science. consistently difficult to access papers. i cringe when i land on their webpage.
November 26, 2025 at 4:42 PM
royal society of chemistry (RSC) has been and continues to be one of the worst outlets for science. consistently difficult to access papers. i cringe when i land on their webpage.
Bit of a tangent but love an opportunity to share this great short essay pmc.ncbi.nlm.nih.gov/articles/PMC...
November 26, 2025 at 2:54 PM
Bit of a tangent but love an opportunity to share this great short essay pmc.ncbi.nlm.nih.gov/articles/PMC...
This is going to be OpenAI’s refrain from here out, and they’ve got the political juice to never get called on it.
“Our tools are cool and good, we told you not to use them like that”
“Our tools are cool and good, we told you not to use them like that”
"It is against the TOS to be talked into suicide by our LLM" is possibly the most evil tech bro thing I've ever read
Additionally, OpenAI argues its not liable because Raine, by using ChatGPT for self-harm, broke its terms of service
November 26, 2025 at 2:38 PM
This is going to be OpenAI’s refrain from here out, and they’ve got the political juice to never get called on it.
“Our tools are cool and good, we told you not to use them like that”
“Our tools are cool and good, we told you not to use them like that”
The marginal cost of software engineering is trending to zero. As scientists, we need to drive the marginal cost of discovery to zero. We need to build systems with this specific intention
November 25, 2025 at 6:42 PM
The marginal cost of software engineering is trending to zero. As scientists, we need to drive the marginal cost of discovery to zero. We need to build systems with this specific intention
Hark! A particle accelerator
November 25, 2025 at 5:28 PM
Hark! A particle accelerator
I'm working through this latest Brian Hie paper. i say it's much more impressive than their recent synthetic bacteriophage work. they demonstrate much higher novelty/diversity, even though one of their main evaluations is sequence recovery (i.e. memorization).
it's a huge paper. i'm still chewing
it's a huge paper. i'm still chewing
Semantic design of functional de novo genes from a genomic language model - Nature
By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined acti...
www.nature.com
November 25, 2025 at 4:38 PM
I'm working through this latest Brian Hie paper. i say it's much more impressive than their recent synthetic bacteriophage work. they demonstrate much higher novelty/diversity, even though one of their main evaluations is sequence recovery (i.e. memorization).
it's a huge paper. i'm still chewing
it's a huge paper. i'm still chewing
Anthropic claims AI models are on the cusp of greatly accelerating laboratory research by designing new experiments, enacting process improvements, and lowering technical barriers. Junior researchers will be far more capable, they claim.
Has anyone seen any evidence of this in practice?
Has anyone seen any evidence of this in practice?
November 25, 2025 at 2:22 PM
Anthropic claims AI models are on the cusp of greatly accelerating laboratory research by designing new experiments, enacting process improvements, and lowering technical barriers. Junior researchers will be far more capable, they claim.
Has anyone seen any evidence of this in practice?
Has anyone seen any evidence of this in practice?
why pick the clothes people wear instead of the noisemaking that is widely considered problematic. tell people to stop driving loud vehicles and to wear headphones
Duffy on his demand that air travelers not wear slippers or pajamas: "It honors our country ... don't take your shoes off and put your feet on the chair ahead of you"
November 24, 2025 at 11:29 PM
why pick the clothes people wear instead of the noisemaking that is widely considered problematic. tell people to stop driving loud vehicles and to wear headphones
learned that Peter Thiel is worried about 'bioweapons' and a lot of tumblers clicked into place
November 24, 2025 at 6:16 PM
learned that Peter Thiel is worried about 'bioweapons' and a lot of tumblers clicked into place
how braindead and cowardly do you gotta be as a member of Congress to retire rather than wield the great power bestowed on you by your constituents
PUNCHBOWL: “.. GOP members messaged us over the weekend saying that they, too, are considering retiring in the middle of the term. Here’s one particularly exercised senior House Republican:
@punchbowlnews.bsky.social
@punchbowlnews.bsky.social
November 24, 2025 at 4:38 PM
how braindead and cowardly do you gotta be as a member of Congress to retire rather than wield the great power bestowed on you by your constituents
I use iPhone 12 mini from 2020. Smallest iPhone ever. I will upgrade when apple does
November 24, 2025 at 1:35 AM
I use iPhone 12 mini from 2020. Smallest iPhone ever. I will upgrade when apple does
working with a grad student on a powerful preprocessing technique for single-cell omics (coming soon!)
i'm emphasizing the meta-science of how to disseminate the workflow and drive adoption. she is resistant ("people will just use it cuz it works"), but marketing is v important i fear
i'm emphasizing the meta-science of how to disseminate the workflow and drive adoption. she is resistant ("people will just use it cuz it works"), but marketing is v important i fear
November 23, 2025 at 6:47 PM
working with a grad student on a powerful preprocessing technique for single-cell omics (coming soon!)
i'm emphasizing the meta-science of how to disseminate the workflow and drive adoption. she is resistant ("people will just use it cuz it works"), but marketing is v important i fear
i'm emphasizing the meta-science of how to disseminate the workflow and drive adoption. she is resistant ("people will just use it cuz it works"), but marketing is v important i fear
no consequences when tech companies lie and break the law and no consequences when government officials lie and break the law
these are fundamentally equivalent and upstream of pretty much all of our problems
these are fundamentally equivalent and upstream of pretty much all of our problems
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
November 23, 2025 at 6:32 PM
no consequences when tech companies lie and break the law and no consequences when government officials lie and break the law
these are fundamentally equivalent and upstream of pretty much all of our problems
these are fundamentally equivalent and upstream of pretty much all of our problems
It’s chemicals. Chemicals and heavy machinery and hard labor. And genetics
what do you think enables food production at scale if not advances in microprocessors, transportation, telecommunications, wireless networking, biomedical sciences, even data centers and machine learning?
Food production is efficient, we make more than we need.
It's all the other useless crap that we need to reduce.
It's all the other useless crap that we need to reduce.
November 23, 2025 at 4:47 PM
It’s chemicals. Chemicals and heavy machinery and hard labor. And genetics
Our system is based on the idea that profits equate to value generation, but these are no longer coupled, if they ever were. profits equate to wealth concentration. value is a byproduct
Why is startup culture always “I am inventing a coffeeproof phone you can put in your coffee cup to keep it warm with cell radiation” and never “I’m inventing a new library wholesaler to replace the single company that is shutting down and sending libraries into crisis”
November 22, 2025 at 6:50 PM
Our system is based on the idea that profits equate to value generation, but these are no longer coupled, if they ever were. profits equate to wealth concentration. value is a byproduct
Claude came up with a plausible original research idea. first time I've seen an LLM succeed at this task.
It proposed coupling mechanosensing with cellular recording to track mechanical history of a cell.
this project is feasible and would be a top-tier paper if successfully demonstrated
It proposed coupling mechanosensing with cellular recording to track mechanical history of a cell.
this project is feasible and would be a top-tier paper if successfully demonstrated
November 22, 2025 at 5:46 PM
Claude came up with a plausible original research idea. first time I've seen an LLM succeed at this task.
It proposed coupling mechanosensing with cellular recording to track mechanical history of a cell.
this project is feasible and would be a top-tier paper if successfully demonstrated
It proposed coupling mechanosensing with cellular recording to track mechanical history of a cell.
this project is feasible and would be a top-tier paper if successfully demonstrated