Six Pasteur scientists win 2025 L’Oréal-UNESCO Young Talents! 🌟 Yolène: Caribbean plants vs dengue mozzies; Leah: gastruloid biophysics; Marion: cancer immunotherapy; Eulalie: menstruation genetics; Sabrina: fixing hearing nerve; Marie: TB & sarcoid immunity. #WomenInScience
October 15, 2025 at 7:41 AM
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Also in Issue 18:
▪️4 Research highlights on cellular junctions, dendrite branching, teeth formation and gastruloid patterning
▪️3 People behind the paper interviews
▪️Transitions in development interview
▪️2 Perspectives
▪️Hypothesis on plant circadian genes
journals.biologists.com/dev/issue/15...
▪️4 Research highlights on cellular junctions, dendrite branching, teeth formation and gastruloid patterning
▪️3 People behind the paper interviews
▪️Transitions in development interview
▪️2 Perspectives
▪️Hypothesis on plant circadian genes
journals.biologists.com/dev/issue/15...
October 7, 2025 at 10:06 AM
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Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
journals.biologists.com
October 3, 2025 at 9:54 AM
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Modifying mechanical constraint guides gastruloid patterning
This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 2, 2025 at 12:10 PM
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Finally, we tested if the AP-gastruloid model can model the neural tube defects by treating Rock inhibitor and Folic acid antagonist. Interestingly, those two treatments demonstrated distinct patterns of defects. (7/n)
September 26, 2025 at 6:10 PM
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scRNA-seq revealed that the AP-gastruloid contained 26 cell types (CS 11 stage), including regionalized neural crest (cranial, vagal, trunk), head and paraxial mesoderm, cardiomyocytes, renal epithelium, and early neurons. (5/n)
September 26, 2025 at 6:10 PM
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Stem-cell-based embryo models (SCBEMs), including Gastruloid models, have pioneered a new avenue in the field of experimental developmental biology. However, the existing human gastruloid models primarily capture posterior embryonic fates. (2/n)
September 26, 2025 at 6:07 PM
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New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
September 26, 2025 at 6:06 PM
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In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
September 26, 2025 at 5:17 PM
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Marvellous send off for @amartinezarias.bsky.social ‘s lab, perfectly located in Gaudi’s La Pedrera. I took no pictures as I was too busy hugging old friends, but the organisers incl @dias-andre.bsky.social pulled off something rly special. Community in science is the real joy of the work we do! 💕
September 22, 2025 at 7:16 AM
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Ever wondered how to get a gastruloid to grow a head?
The Bulut-Karslioğlu lab figured out that by growing different stem cell aggregates in high and low oxygen and later assembling them, you can get gastruloids with a fully formed neural tube. Check out our "In preprints": doi.org/10.1242/dev....
The Bulut-Karslioğlu lab figured out that by growing different stem cell aggregates in high and low oxygen and later assembling them, you can get gastruloids with a fully formed neural tube. Check out our "In preprints": doi.org/10.1242/dev....
In preprints: gastruloids get (a)head
A major breakthrough in the field of mammalian embryology is the development of stem-cell based embryo models. Derived from pluripotent stem cells, such as embryonic stem cells or induced pluripotent ...
doi.org
September 16, 2025 at 8:31 AM
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(11/14)
Building on this we can identify features that correlate with the observed patterning classes. The 3D patterning maps thus provide framework to systematically investigate gastruloid patterning spaces!
Building on this we can identify features that correlate with the observed patterning classes. The 3D patterning maps thus provide framework to systematically investigate gastruloid patterning spaces!
September 12, 2025 at 12:44 PM
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(4/14) Using manual annotations to benchmark the spine is a crucial but in 3D annotation can be challenging. To have a second method of verification I generated synthetic gastruloids with some Perlin noise to generate realistic structures (like this wobbly gastruloid)
September 12, 2025 at 12:44 PM
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For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
September 5, 2025 at 5:30 PM
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Experiments showed NHC significantly disrupted morphological progression and gene expression in mouse and human gastruloid models at concentrations comparable to human plasma levels.
September 3, 2025 at 7:07 PM
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Molnupiravir, a COVID-19 drug, may pose developmental risks. Gastruloid models reveal it impairs embryo-like growth at clinically relevant doses, offering a faster, animal-free way to ass...
🧵 Thread below
Full analysis: https://helixbrief.com/article/b54d85f2-8218-4094-ac75-59b9bbb9d30d
🧵 Thread below
Full analysis: https://helixbrief.com/article/b54d85f2-8218-4094-ac75-59b9bbb9d30d
September 3, 2025 at 7:07 PM
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Huge congrats to our very first PhD student David Xiang for successful defense!
Kudoso to our team, committee members, collaborators to support his work on human gastruloid and critical genes for transcriptional regulation in organogenesis
Kudoso to our team, committee members, collaborators to support his work on human gastruloid and critical genes for transcriptional regulation in organogenesis
September 3, 2025 at 10:15 AM
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We've updated our biorxiv! Check it out if you're interested in a new technique co-profiling RNA and epigenetics in single cells, extended gastruloid culture, and our proposed model for an epigenetic timer determining sequential perceptiveness to different lineages! ➡️ www.biorxiv.org/content/10.1...
August 30, 2025 at 3:12 PM
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Did you know we have a new 'Browse by subject' page?
Explore Development's content, now easily accessible by subject area:
journals.biologists.com/dev/pages/br...
Explore Development's content, now easily accessible by subject area:
journals.biologists.com/dev/pages/br...
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:btitwyhiegkb6f62oguxt6m6/bafkreidodsogogxj5buby6i664734er4erkr6bvnx2afc5iyreugc7pcqa@jpeg)
August 17, 2025 at 12:55 PM
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In sum, our findings highlight polyadenylation-mediated control of transcript stability as a critical mechanism in shaping the mammalian body plan and position gastruloid-based single-cell CRISPR screening as a powerful platform for systematic discovery of developmental regulators.
August 6, 2025 at 4:14 PM
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Our screen revealed several novel regulators of germ layer differentiation, including a strong paraxial mesoderm-specific role of the CCR4-NOT component Cnot8. Loss of Cnot8 resulted in gastruloid patterning defects such as the formation of multiple Brachyury poles and aberrant growth.
August 6, 2025 at 4:14 PM
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Further evidence that the #gastruloid system models the natural embryo from this spatiotemporal map of mouse #gastrulation
www.cell.com/cell-reports...
important as it provides a context for the, some times surprising, findings that the model is providing.
www.cell.com/cell-reports...
important as it provides a context for the, some times surprising, findings that the model is providing.
August 3, 2025 at 10:04 PM
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Pre-gastruloid era.
Learnt a lot and got all the questions for which Drosophila did not have an answer to but maybe PSCs would......then we got more questions....and some answers.
Learnt a lot and got all the questions for which Drosophila did not have an answer to but maybe PSCs would......then we got more questions....and some answers.
July 31, 2025 at 1:33 PM
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….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
July 23, 2025 at 3:20 PM
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Did you know we have a new 'Browse by subject' page?
Explore Development's content, now easily accessible by subject area:
journals.biologists.com/dev/pages/br...
Explore Development's content, now easily accessible by subject area:
journals.biologists.com/dev/pages/br...
July 17, 2025 at 12:55 PM
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