Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Pinned
Jeff Mold
@jeffmold.bsky.social
· Nov 15
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
Reposted by Jeff Mold
'As we observe in our paper ‘[w]hile rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work.’'
blogs.lse.ac.uk/impactofsoci...
blogs.lse.ac.uk/impactofsoci...
Money, Time, Trust, Control – How commercial publishers drain science - Impact of Social Sciences
Have the interests of commercial publishers now become antithetical to the pursuit of knowledge?
blogs.lse.ac.uk
November 19, 2025 at 5:04 PM
'As we observe in our paper ‘[w]hile rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work.’'
blogs.lse.ac.uk/impactofsoci...
blogs.lse.ac.uk/impactofsoci...
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
November 24, 2025 at 7:58 AM
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
Reposted by Jeff Mold
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
How high are OpenAI’s compute costs? Possibly a lot higher than we thought
Inference inferred, revenue reconstructed, cash burn quantified
www.ft.com
November 22, 2025 at 2:13 PM
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
Holy crap the USA is really a full blown idiocracy now - to quote their leader SAD!!! www.nature.com/articles/d41...
Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance
The Make America Healthy Again summit, attended by health secretary Robert F. Kennedy Jr and vice-president JD Vance, gave a sense of what’s driving US health policy.
www.nature.com
November 22, 2025 at 12:01 PM
Holy crap the USA is really a full blown idiocracy now - to quote their leader SAD!!! www.nature.com/articles/d41...
Reposted by Jeff Mold
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
November 21, 2025 at 8:15 PM
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
Reposted by Jeff Mold
New midweek podcast! Check your feeds 👇
Hats off to @onthemedia.bsky.social for calling out the spam machines behind politics. Bravo! I for one, have created a series of filters and fake emails just to defeat this crapola pain in the butt money shilling. Damn, I hope Dems take the hint.
www.wnycstudios.org/podcasts/otm...
www.wnycstudios.org/podcasts/otm...
The Democratic Party's Spam Machine | On the Media | WNYC Studios
If you’ve ever donated to a Democratic candidate, you’ve probably been rewarded with a never-ending stream of pleas for more money.
www.wnycstudios.org
November 20, 2025 at 7:40 PM
New midweek podcast! Check your feeds 👇
Interesting: www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 7:36 PM
Interesting: www.science.org/doi/10.1126/...
Reposted by Jeff Mold
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 9:00 PM
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Love Kevin Mitchell’s views on big data - open.spotify.com/episode/01w8...
Autism, Microbiomes, & Mice Burying Marbles with Kevin Mitchell
open.spotify.com
November 19, 2025 at 10:14 AM
Love Kevin Mitchell’s views on big data - open.spotify.com/episode/01w8...
Reposted by Jeff Mold
"academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it... The dominant four collectively generated... $12 billion in profits between 2019 and 2024."
November 18, 2025 at 6:48 AM
"academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it... The dominant four collectively generated... $12 billion in profits between 2019 and 2024."
Reposted by Jeff Mold
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by Jeff Mold
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
November 18, 2025 at 7:22 AM
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
Ohhhhh mammoth atlases en route. In 5 years when they get some nuclei we may get spatiotemporal mammoth multiomic data revealing conserved and non conserved patterns of differentiation!
Scientists have extracted the oldest RNA molecules out of a wooly mammoth, gaining a snapshot into the processes at work in the extinct mammal's body just before it died. n.pr/4patABW
Scientists pull ancient RNA from a wooly mammoth's body
Scientists have extracted the oldest RNA molecules out of a wooly mammoth, gaining a snapshot into the processes at work in the extinct mammal's body just before it died.
n.pr
November 14, 2025 at 6:02 PM
Ohhhhh mammoth atlases en route. In 5 years when they get some nuclei we may get spatiotemporal mammoth multiomic data revealing conserved and non conserved patterns of differentiation!
One of the worst things that can happen to you as a scientist is to have a long non-coding RNA show up as your grad student’s favorite gene in a differential expression analysis
rick morty from rick and morty is sitting on a couch with a serious look on his face .
ALT: rick morty from rick and morty is sitting on a couch with a serious look on his face .
media.tenor.com
November 14, 2025 at 4:42 PM
One of the worst things that can happen to you as a scientist is to have a long non-coding RNA show up as your grad student’s favorite gene in a differential expression analysis
November 13, 2025 at 7:57 PM
Reposted by Jeff Mold
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Jeff Mold
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 5:47 PM
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I wish there was an AI tool where one could give it IF microscopy images from a known tissue and get a list of likely proteins that have the precise distribution of the fluorescent signal
November 9, 2025 at 4:08 PM
I wish there was an AI tool where one could give it IF microscopy images from a known tissue and get a list of likely proteins that have the precise distribution of the fluorescent signal
Reposted by Jeff Mold
Have you no decency?
It's time to start asking questions
open.substack.com
October 27, 2025 at 3:03 AM
Reposted by Jeff Mold
There is something deeply rotten at the heart of modern tech that goes well beyond the corruptions produced by capitalism.
“authors & publishers who filed a lawsuit against the Sam Altman-led firm have secured access to internal Slack messages… discussing the mass deletion of a pirated books dataset… A NY district court ordered OpenAI to hand over the communications regarding data deletion”
futurism.com/artificial-i...
futurism.com/artificial-i...
OpenAI in Danger After Authors Suing It Gain Access to Its Internal Slack Messages
Authors and publishers, who are suing OpenAI, secured access to internal Slack messages and emails discussing the deletion of pirated books.
futurism.com
November 9, 2025 at 12:00 PM
There is something deeply rotten at the heart of modern tech that goes well beyond the corruptions produced by capitalism.