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Daniel Peeper Lab

@peeperlab.bsky.social

1.5K followers 80 following 5 posts

Cancer researcher @NKI_nl and @oncodeinstitute, Cofounder of Flindr Tx; developing rational cancer & immune cell combination treatments using functional genomics

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Reposted by Daniel Peeper Lab

Netherlands Cancer Institute @nkinl.bsky.social · Jul 7

In a new Nature Genetics paper our researchers identified a synthetic lethal interaction in 50% of cancers. Tumors lacking CDS1 depend entirely on CDS2. Blocking CDS2 kills cancer cells while sparing healthy tissue ➡️ www.nki.nl/news-events/...

High-resolution microscopy of a mesenchymal cancer cell that has been killed by inactivating the CDS2 gene. Prior to cell death, tiny lipid droplets accumulated, which are still visible as cyan-colored dots, visualized using fluorescence microscopy. The DNA of the dead cancer cells (magenta) is dispersed throughout the surrounding area.
Processed image by Tim Arnoldus, Gemma Driessen and Marjolein Mertz. Legend: magenta = DNA from dead cancer, cyan = lipid droplets

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Daniel Peeper Lab @peeperlab.bsky.social · Jul 4

The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research of international top investigators. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to network. Join us! smrcongress.org

Society Melanoma Research Congress

smrcongress.org

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Daniel Peeper Lab @peeperlab.bsky.social · Jul 4

Major congratulations to my PhD student Tim Arnoldus @nkinl.bsky.social @oncodeinstitute.bsky.social ‬on publishing his exciting discovery today in Nature Genetics! 🎉
By computational mining Tim found a synthetic lethal target that may impact future treatment of half of all cancers.👏
t.co/cQdeYQinsX

https://www.nature.com/articles/s41588-025-02221-2

t.co

Daniel Peeper Lab @peeperlab.bsky.social · Jan 24

Congrats to Sofía Ibáñez Molero @NKI_nl and
@oncodeinstitute for excellently defending her PhD thesis, on functional interactions between cancer and the immune system, with several interesting papers already published and under review. Great work Sofía and best of luck with your postdoc!

Daniel Peeper Lab @peeperlab.bsky.social · Jan 14

📢 Applications for the NKI PhD program now open till Feb 28. Several exciting positions available, including one in my lab on discovering new biology and therapeutic opportunities of a population of enriched tumor-reactive T cells we recently identified.

www.nki.nl/careers-stud...

NKI PhD program 2025 | Cancer Biology | Netherlands Cancer Institute

We are looking for outstanding candidates who want to become our new generation of ambitious PhD students, and join our lively international research community.

www.nki.nl

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Reposted by Daniel Peeper Lab

Netherlands Cancer Institute @nkinl.bsky.social · Dec 13

More knowledge about immunotherapy, advanced diagnostics, and reducing overtreatment. Thanks to financial support from KWF Dutch Cancer Society, 13 research teams from the Netherlands Cancer Institute are launching new projects ➡️ www.nki.nl/news-events/...

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Reposted by Daniel Peeper Lab

Netherlands Cancer Institute @nkinl.bsky.social · Nov 29

📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq

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Daniel Peeper Lab @peeperlab.bsky.social · Nov 17

My first post here: Congrats to David Vredevoogd from my lab @NKI_nl
@oncodeinstitute + collaborators for reporting on TMED, a new regulator of both immune checkpoints PD-1 and CTLA-4, which is amenable to therapeutic intervention. Read the paper here jitc.bmj.com/content/12/1...

TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction

Background Blockade of the programmed cell death protein 1 (PD-1) immune checkpoint (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression on CD8 T ...

jitc.bmj.com

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