Hao Yin
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haoyin.bsky.social
Hao Yin
@haoyin.bsky.social
4.6K followers 7.5K following 1.9K posts
Twitter/X @haoyin20
Vascular biologist
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haoyin.bsky.social
Hao Yin @haoyin.bsky.social · 5d
“Time is brain” for cell therapies?🧠

Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social

#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock

advanced.onlinelibrary.wiley.com/doi/10.1002/...
haoyin.bsky.social
Single-nucleus profiling of Ossabaw pig🐷#Atherosclerosis model
Castrated♂️ 16-mo
+High fat & high fructose diet for 9 mo

Smooth muscle cell subclusters
⏬ACAA2+ SMC
⏬TRPC4+ SMC
⏫SPP1+ SMC
⏫NFATC2+ SMC

⏫Pericyte BDNF TGFβ Oncostatin M

⏫Myeloid SEMA3C

#iScience 2025
www.cell.com/iscience/ful...
November 23, 2025 at 8:00 PM
Reposted by Hao Yin
slavov-n.bsky.social
miRNA have multiple functions beyond their role in modulating translation.
November 23, 2025 at 3:18 PM
haoyin.bsky.social
#RNAEditing #PulmonaryArterialHypertension

ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)

SMC ADAR1 KO🐭 excerbates PAH

SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation

@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
November 23, 2025 at 12:37 PM
Reposted by Hao Yin
cardioob.bsky.social
🚀 Excited to launch a new series to keep #CardioObstetrics community updated with high-yield research in under 90 seconds.

“90-Second Cardio-OB Journal Scan”
with @cardioobdoc.bsky.social

Nov 14, 2025 article from @AJOG_thegray
🔗 www.ajog.org/article/S000...

#CardioSky #ACCRepOB #ACCCardioOB
November 14, 2025 at 2:23 PM
Reposted by Hao Yin
aaandmoore.bsky.social
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
November 21, 2025 at 3:54 AM
Reposted by Hao Yin
ekatrukha.bsky.social
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 9:29 AM
Reposted by Hao Yin
aaandmoore.bsky.social
vimeo.com/1139537563?s...

I uploaded a version of that vimentin IF movie to my vimeo page. It's still compressed, but looks a lot better. Best results when you set the quality to 4k.
24FPS_VimentinCos7GIF_4320p_ultraHQ
This is "24FPS_VimentinCos7GIF_4320p_ultraHQ" by Andy Moore on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
November 22, 2025 at 4:25 AM
Reposted by Hao Yin
svi.nl
Happy #FluorescenceFriday! LSCM images of mixed species of Radiolaria, zooplankton. Huygens deconvolved to lure out elusive weak autofluorescence signal and noisy background. Thank you Outi Paloheimo (Imaging Facility of Tampere University)!

Interested in participating? Join: svi.nl/ImageContest
November 21, 2025 at 8:48 AM
haoyin.bsky.social
PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery

PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis

#CardiovascRes 2023
academic.oup.com/cardiovascre...
November 22, 2025 at 8:22 PM
Reposted by Hao Yin
kaminskimed.bsky.social
Finally a good animal model of human Pulmonary Fibrosis?
The Ferret bleomycin shares IPF features including: patchy distribution of fibrotic foci, honeycomb cyst-likes, ⬆️ blood MMP7, KL6, presence aberrant epithelial basaloid cells.
Kudos DrsWu, Liu & team
#CureIPF
www.nature.com/articles/s41...
Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis - npj Regenerative Medicine
npj Regenerative Medicine - Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis
www.nature.com
November 22, 2025 at 5:25 PM
Reposted by Hao Yin
abeisaw.bsky.social
Come join us in Heidelberg for the first German fish meeting 👩‍🔬👨‍🔬🧬🔬🐟🐠
November 22, 2025 at 4:03 PM
Reposted by Hao Yin
lozanzi.bsky.social
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology
Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.
www.nature.com
November 22, 2025 at 3:58 PM
Reposted by Hao Yin
craigagoodman1.bsky.social
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis
skeletalmusclejournal.biomedcentral.com/articles/10....
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis - Skeletal Muscle
Background Skeletal muscle is a dynamic tissue capable of structural and metabolic remodeling in response to physiological and pathological stimuli. These adaptations are central to understanding the ...
skeletalmusclejournal.biomedcentral.com
November 22, 2025 at 4:12 PM
Reposted by Hao Yin
craigagoodman1.bsky.social
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications
Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...
www.nature.com
November 22, 2025 at 4:13 PM
Reposted by Hao Yin
jytinevez.bsky.social
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.

It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
Reposted by Hao Yin
manuelthery.bsky.social
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
November 21, 2025 at 1:07 PM
haoyin.bsky.social
CellWhisperer

From Transcriptome to Text

A great LLM-Chatbot explorer for CELLxGENE & GEO & your own data!

Contrastive language image pretraining
Geneformer
BioBERT
>1 million bulk/pseudo-bulk transcriptomes

cellwhisperer.bocklab.org

#NatBiotech 2025
www.nature.com/articles/s41...
November 22, 2025 at 12:14 PM
haoyin.bsky.social
Senolytic CAR-T

"Ablation of uPAR+ intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged intestinal stem cells", improves gut barrier integrity & mucosal immune function

bioRxiv 2025
www.biorxiv.org/content/10.1...
November 21, 2025 at 7:52 PM
Reposted by Hao Yin
markelindsay.bsky.social
Guy who looks and talks like Krang doesn't want you to protect your kids
nytimes.com The New York Times @nytimes.com · 2d
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
RFK Jr. Says He Instructed CDC to Change Vaccines and Autism Language on Website
In an interview, Health Secretary Robert F. Kennedy Jr. cited gaps in vaccine safety research. His critics say he is ignoring a larger point: Vaccines save lives.
nyti.ms
November 21, 2025 at 7:16 PM
Reposted by Hao Yin
ericchevet.bsky.social
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
bims-proteo 2025-11-16 papers
biomed.news
November 21, 2025 at 7:46 PM
Reposted by Hao Yin
jeffhsumd.bsky.social
Very proud to share our lab’s recently published work in AJP-Heart

Early in my NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNF

🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @haoyin.bsky.social for summary!)

journals.physiology.org/doi/full/10....
Few select images from linked paper
November 21, 2025 at 1:54 PM
Reposted by Hao Yin
devbiol.bsky.social
#DBfeature 🧠🐣

Distinct functional domains of ASCL1 uniquely control neuronal differentiation and subtype identity, revealing the structural code behind neural fate decisions.

By Yuji Nakada, Madison Martinez, and Jane Johnson

tinyurl.com/3b6b325m
HH14-16 chick neural tubes were electroporated in ovo with constructs expressing MYC-tagged vectors: control empty vector (A, A′), ASCL1 (B, B′), ASCL1NR−AQ (C, C′), ASCL1E−G (D, D′), ASCL1N−A (E, E′), ASCL1R−Q (F, F′), or ASCL1E−G/NR−AQ (G, G′), and harvested 24 h later (HH23-24). A cartoon of a chick embryo and a transverse section of the neural tube is shown in the top middle, with the boxed region representing that imaged in A-G’ (+ is the electroporated side). (A-G′) Immunofluorescence with anti-MYC antibody indicating transgene expression in the electroporated cells (red). BrdU incorporation was used to detect proliferating cells (A-G, green), and RBFOX3 identifies differentiating neurons (A′-G′, green). (H–I) The percentage of electroporated cells (red) co-expressing BrdU (H) and RBFOX3 (I) is shown. ASCL1 induces cells to move laterally out of the ventricular zone, express the neuronal marker RBFOX3, and exit the cell cycle. Black asterisks indicate those cases significantly different from wild-type ASCL1 overexpression. Red asterisks highlight the mutants that decrease co-expression with RBFOX3 relative to control (I). Each data point represents a biological replicate, and the error bars are SEM around the mean, unpaired t-test, ∗∗p 0.001, ∗p 0.01, ns = not significant.
November 21, 2025 at 2:20 PM
Reposted by Hao Yin
sorengrubb.bsky.social
In 🐁🧠, #ultrastructure shows that #pericyte #cilia are often ensheathed by #astrocytic #endfeet. In 🚶‍♀️🧠, #astrocytes are swollen and cilia stay confined within the basal lamina. What are they sensing from the astrocytes?
🧪🧵4/8
November 20, 2025 at 9:04 PM
Reposted by Hao Yin
sorengrubb.bsky.social
🗺️We mapped #MuralCells — including #pericytes and #smoothmuscle — as vectors➡️ to visualize where #PrimaryCilia🌟 occur across the 🐁🧠 #microvasculature.
The result? A striking pattern: #cilia are abundant on #capillaries and #venules, but almost absent on #arterioles.
🧪🧵3/8
November 20, 2025 at 9:04 PM
Reposted by Hao Yin
sorengrubb.bsky.social
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM