Craig A. Goodman
LightNews LightNews
banner
craigagoodman1.bsky.social
Craig A. Goodman
@craigagoodman1.bsky.social
500 followers 270 following 690 posts
Senior Scientist that investigates the molecular mechanisms that regulate skeletal muscle mass and function in health and in various disease states. Protein synthesis, ubiquitin biology.
https://scholar.google.com.au/citations?user=ICAcUqUAAAAJ&hl=en
Posts Replies Media Videos
craigagoodman1.bsky.social
Proteomics-based evaluation of AAV dystrophin gene therapy outcomes in mdx skeletal muscle
insight.jci.org/articles/vie...
JCI Insight - Proteomics-based evaluation of AAV dystrophin gene therapy outcomes in mdx skeletal muscle
insight.jci.org
November 28, 2025 at 8:56 PM
craigagoodman1.bsky.social
Exercise enhances antioxidant protein levels in oxidative skeletal muscle via IL-1β
journals.physiology.org/doi/abs/10.1...
Exercise enhances antioxidant protein levels in oxidative skeletal muscle via IL-1β | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | American Physiological Society
Nrf2 activation by sequestosome1/p62 (p62) (Ser351) phosphorylation is a pivotal signal for the exercise-mediated augmentation of antioxidant protein expression in muscle. However, the molecular mecha...
journals.physiology.org
November 28, 2025 at 8:56 PM
craigagoodman1.bsky.social
Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations
We sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter-genotype fecal microbiota transplantations (FMT) between wildtype (C57....
faseb.onlinelibrary.wiley.com
November 28, 2025 at 8:54 PM
craigagoodman1.bsky.social
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism
www.nature.com/articles/s41...
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism - Nature Communications
Skeletal muscle is central to whole-body energy balance. Here, Yang et al. show that MLL4-dependent enhancer activation is a key regulatory node for the governance of muscle metabolic efficiency and s...
www.nature.com
November 27, 2025 at 7:22 PM
craigagoodman1.bsky.social
Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers
www.mdpi.com/2072-6643/17...
www.mdpi.com
November 27, 2025 at 7:21 PM
craigagoodman1.bsky.social
Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy
www.nature.com/articles/s41...
Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy - Gene Therapy
Gene Therapy - Codon-optimized human Smad7 gene therapy enhances skeletal muscle mass and function in a murine model of Duchenne muscular dystrophy
www.nature.com
November 26, 2025 at 7:30 PM
craigagoodman1.bsky.social
Fiber Type and Stimulus Determine Progression of Skeletal Muscle Atrophy
www.biorxiv.org/content/10.1...
Fiber Type and Stimulus Determine Progression of Skeletal Muscle Atrophy
Background Skeletal muscle atrophy is prevalent worldwide and is a major detractor from length and quality of life. It is often diagnosed and treated as a single disorder, but the causal stimuli and p...
www.biorxiv.org
November 26, 2025 at 7:28 PM
craigagoodman1.bsky.social
Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles
onlinelibrary.wiley.com/doi/10.1002/...
Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles
Introduction Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes.....
onlinelibrary.wiley.com
November 25, 2025 at 10:11 PM
craigagoodman1.bsky.social
Effect of Neuromuscular Electrical Stimulation for Older Critically Ill Patients in the ICU: A Randomized Controlled Trial
journals.lww.com/ccejournal/f...
journals.lww.com
November 25, 2025 at 10:09 PM
craigagoodman1.bsky.social
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 25, 2025 at 7:54 AM
craigagoodman1.bsky.social
Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 8:23 PM
craigagoodman1.bsky.social
The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 8:22 PM
craigagoodman1.bsky.social
Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues
www.sciencedirect.com/science/chap...
Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues
Communication between tissues or different cells within a tissue is often a result of secreted molecules such as metabolites, lipids, nucleic acids, o…
www.sciencedirect.com
November 24, 2025 at 8:21 PM
craigagoodman1.bsky.social
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
aacrjournals.org/cancerrescom...
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
Abstract. Preclinical models of pancreatic ductal adenocarcinoma (PDAC) can greatly benefit from noninvasive imaging for evaluating disease progression and therapeutic response. Imaging approaches tha...
aacrjournals.org
November 24, 2025 at 8:17 PM
craigagoodman1.bsky.social
Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1-Mediated Apoptosis and Pyroptosis
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Ubiquitin Specific Peptidase 51 Exacerbates Skeletal Muscle Injury by Enhancing APAF1‐Mediated Apoptosis and Pyroptosis
In the Skeletal Muscle Injury (SMI) microenvironment, Ubiquitin Specific Peptidase 51 (USP51) expression is significantly upregulated, functional studies uncovered that USP51 interacts with and deubi...
faseb.onlinelibrary.wiley.com
November 23, 2025 at 7:31 PM
craigagoodman1.bsky.social
Profiling muscle mass, function and molecular signalling in females aged 18-80 years and their associations with sex hormones
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Profiling muscle mass, function and molecular signalling in females aged 18–80 years and their associations with sex hormones
Abstract figure legend This study mapped the trajectory of muscle ageing at the whole-body, whole-muscle and cellular level in 96 healthy females aged between 18 and 80 years old, whilst controlling ...
physoc.onlinelibrary.wiley.com
November 23, 2025 at 7:29 PM
Reposted by Craig A. Goodman
aups-physiology.bsky.social
🎉 Today’s the day! AuPS 2025 has officially begun in Parramatta!
We’re ready for four days of physiology, networking, new collaborations — and lots of science in action.
📸 Don’t forget to join the social media challenge!
Post publicly using #AuPS2025 #Physiology
November 23, 2025 at 2:06 AM
craigagoodman1.bsky.social
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications
Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...
www.nature.com
November 22, 2025 at 4:13 PM
craigagoodman1.bsky.social
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis
skeletalmusclejournal.biomedcentral.com/articles/10....
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis - Skeletal Muscle
Background Skeletal muscle is a dynamic tissue capable of structural and metabolic remodeling in response to physiological and pathological stimuli. These adaptations are central to understanding the ...
skeletalmusclejournal.biomedcentral.com
November 22, 2025 at 4:12 PM
craigagoodman1.bsky.social
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice
molmed.biomedcentral.com/articles/10....
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice - Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogen...
molmed.biomedcentral.com
November 21, 2025 at 7:30 PM
craigagoodman1.bsky.social
Daily Myofibrillar Protein Synthesis Rates Do Not Differ During Interval Compared to Continuous Exercise Training Matched for Duration and Work in Healthy Young Men
journals.humankinetics.com/view/journal...
journals.humankinetics.com
November 21, 2025 at 7:27 PM
craigagoodman1.bsky.social
Effects of repetition duration on skeletal muscle hypertrophy in a rat model of resistance exercise
journals.physiology.org/doi/abs/10.1...
Effects of repetition duration on skeletal muscle hypertrophy in a rat model of resistance exercise | Journal of Applied Physiology | American Physiological Society
This study aimed to elucidate the effects of repetition duration (contraction duration for each repetition) of resistance exercise on muscle hypertrophy and its underlying mechanisms using a rat exerc...
journals.physiology.org
November 21, 2025 at 7:26 PM
craigagoodman1.bsky.social
Utilizing accelerated and delayed murine models of aging to address the "healthspan issue" - A review of skeletal muscle health
www.sciencedirect.com/science/arti...
Utilizing accelerated and delayed murine models of aging to address the “healthspan issue” – A review of skeletal muscle health
The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or …
www.sciencedirect.com
November 20, 2025 at 4:38 PM
craigagoodman1.bsky.social
HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
November 20, 2025 at 4:37 PM
craigagoodman1.bsky.social
A Single Day of Reduced Activity Alters the Next Day's Transcriptomic and Metabolic Exercise Response
journals.physiology.org/doi/abs/10.1...
A Single Day of Reduced Activity Alters the Next Day’s Transcriptomic and Metabolic Exercise Response | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society
Regular aerobic exercise decreases the risk of metabolic diseases; however, reduced physical activity may attenuate these beneficial adaptations. This study investigated the influence of a single day ...
journals.physiology.org
November 18, 2025 at 4:26 PM