Hao Yin
@haoyin.bsky.social
Twitter/X @haoyin20
Vascular biologist
Vascular biologist
Downregulated FGF9 in type 2 diabetic #SkeletalMuscle
db/db🐭
Re-analysis of Human SkM #T2D #Sarcopenia transcriptomes
Hub genes: FGF9 BDH1 LDHA
#SciRep 2025
www.nature.com/articles/s41...
db/db🐭
Re-analysis of Human SkM #T2D #Sarcopenia transcriptomes
Hub genes: FGF9 BDH1 LDHA
#SciRep 2025
www.nature.com/articles/s41...
November 25, 2025 at 8:16 PM
Downregulated FGF9 in type 2 diabetic #SkeletalMuscle
db/db🐭
Re-analysis of Human SkM #T2D #Sarcopenia transcriptomes
Hub genes: FGF9 BDH1 LDHA
#SciRep 2025
www.nature.com/articles/s41...
db/db🐭
Re-analysis of Human SkM #T2D #Sarcopenia transcriptomes
Hub genes: FGF9 BDH1 LDHA
#SciRep 2025
www.nature.com/articles/s41...
Hao's Preprint Reading List
November 25th 2025
Ion channels in Lymphatic vessels
Liver inflammation in Pulmonary arterial hypertension
Perfusable Endometriosis on a chip
Piezo1, Angiopoietin 2, Schlemm's Canal
Spiral artery remodeling in human pregnancy
docs.google.com/document/d/e...
November 25th 2025
Ion channels in Lymphatic vessels
Liver inflammation in Pulmonary arterial hypertension
Perfusable Endometriosis on a chip
Piezo1, Angiopoietin 2, Schlemm's Canal
Spiral artery remodeling in human pregnancy
docs.google.com/document/d/e...
November 25, 2025 at 1:03 PM
Hao's Preprint Reading List
November 25th 2025
Ion channels in Lymphatic vessels
Liver inflammation in Pulmonary arterial hypertension
Perfusable Endometriosis on a chip
Piezo1, Angiopoietin 2, Schlemm's Canal
Spiral artery remodeling in human pregnancy
docs.google.com/document/d/e...
November 25th 2025
Ion channels in Lymphatic vessels
Liver inflammation in Pulmonary arterial hypertension
Perfusable Endometriosis on a chip
Piezo1, Angiopoietin 2, Schlemm's Canal
Spiral artery remodeling in human pregnancy
docs.google.com/document/d/e...
#MetaplasticBreastCancer #Immunotherapy
Pathological complete response was achieved in
1⃣2/33 Neoadjuvant Chemo
2⃣2/7 Neoadjuvant Chemo + Immunotherapy
Love to see some immunopathology on tumor-infiltrating lymphocytes & PD-L1
#BreastCancer 2025
www.dovepress.com/promising-re...
Pathological complete response was achieved in
1⃣2/33 Neoadjuvant Chemo
2⃣2/7 Neoadjuvant Chemo + Immunotherapy
Love to see some immunopathology on tumor-infiltrating lymphocytes & PD-L1
#BreastCancer 2025
www.dovepress.com/promising-re...
November 24, 2025 at 8:01 PM
#MetaplasticBreastCancer #Immunotherapy
Pathological complete response was achieved in
1⃣2/33 Neoadjuvant Chemo
2⃣2/7 Neoadjuvant Chemo + Immunotherapy
Love to see some immunopathology on tumor-infiltrating lymphocytes & PD-L1
#BreastCancer 2025
www.dovepress.com/promising-re...
Pathological complete response was achieved in
1⃣2/33 Neoadjuvant Chemo
2⃣2/7 Neoadjuvant Chemo + Immunotherapy
Love to see some immunopathology on tumor-infiltrating lymphocytes & PD-L1
#BreastCancer 2025
www.dovepress.com/promising-re...
u-Segment3D
Universal consensus 3D segmentation of cells from 2D segmented stacks
Work on complex networks, organelles & even endothelial filopodia🤯
A solid step toward single-cell 3D spatial omics 👹
@natmethods.nature.com 2025
www.nature.com/articles/s41...
Universal consensus 3D segmentation of cells from 2D segmented stacks
Work on complex networks, organelles & even endothelial filopodia🤯
A solid step toward single-cell 3D spatial omics 👹
@natmethods.nature.com 2025
www.nature.com/articles/s41...
November 24, 2025 at 12:44 PM
u-Segment3D
Universal consensus 3D segmentation of cells from 2D segmented stacks
Work on complex networks, organelles & even endothelial filopodia🤯
A solid step toward single-cell 3D spatial omics 👹
@natmethods.nature.com 2025
www.nature.com/articles/s41...
Universal consensus 3D segmentation of cells from 2D segmented stacks
Work on complex networks, organelles & even endothelial filopodia🤯
A solid step toward single-cell 3D spatial omics 👹
@natmethods.nature.com 2025
www.nature.com/articles/s41...
Single-nucleus profiling of Ossabaw pig🐷#Atherosclerosis model
Castrated♂️ 16-mo
+High fat & high fructose diet for 9 mo
Smooth muscle cell subclusters
⏬ACAA2+ SMC
⏬TRPC4+ SMC
⏫SPP1+ SMC
⏫NFATC2+ SMC
⏫Pericyte BDNF TGFβ Oncostatin M
⏫Myeloid SEMA3C
#iScience 2025
www.cell.com/iscience/ful...
Castrated♂️ 16-mo
+High fat & high fructose diet for 9 mo
Smooth muscle cell subclusters
⏬ACAA2+ SMC
⏬TRPC4+ SMC
⏫SPP1+ SMC
⏫NFATC2+ SMC
⏫Pericyte BDNF TGFβ Oncostatin M
⏫Myeloid SEMA3C
#iScience 2025
www.cell.com/iscience/ful...
November 23, 2025 at 8:00 PM
Single-nucleus profiling of Ossabaw pig🐷#Atherosclerosis model
Castrated♂️ 16-mo
+High fat & high fructose diet for 9 mo
Smooth muscle cell subclusters
⏬ACAA2+ SMC
⏬TRPC4+ SMC
⏫SPP1+ SMC
⏫NFATC2+ SMC
⏫Pericyte BDNF TGFβ Oncostatin M
⏫Myeloid SEMA3C
#iScience 2025
www.cell.com/iscience/ful...
Castrated♂️ 16-mo
+High fat & high fructose diet for 9 mo
Smooth muscle cell subclusters
⏬ACAA2+ SMC
⏬TRPC4+ SMC
⏫SPP1+ SMC
⏫NFATC2+ SMC
⏫Pericyte BDNF TGFβ Oncostatin M
⏫Myeloid SEMA3C
#iScience 2025
www.cell.com/iscience/ful...
#RNAEditing #PulmonaryArterialHypertension
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
November 23, 2025 at 12:37 PM
#RNAEditing #PulmonaryArterialHypertension
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
November 22, 2025 at 8:22 PM
PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery
PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis
#CardiovascRes 2023
academic.oup.com/cardiovascre...
CellWhisperer
From Transcriptome to Text
A great LLM-Chatbot explorer for CELLxGENE & GEO & your own data!
Contrastive language image pretraining
Geneformer
BioBERT
>1 million bulk/pseudo-bulk transcriptomes
cellwhisperer.bocklab.org
#NatBiotech 2025
www.nature.com/articles/s41...
From Transcriptome to Text
A great LLM-Chatbot explorer for CELLxGENE & GEO & your own data!
Contrastive language image pretraining
Geneformer
BioBERT
>1 million bulk/pseudo-bulk transcriptomes
cellwhisperer.bocklab.org
#NatBiotech 2025
www.nature.com/articles/s41...
November 22, 2025 at 12:14 PM
CellWhisperer
From Transcriptome to Text
A great LLM-Chatbot explorer for CELLxGENE & GEO & your own data!
Contrastive language image pretraining
Geneformer
BioBERT
>1 million bulk/pseudo-bulk transcriptomes
cellwhisperer.bocklab.org
#NatBiotech 2025
www.nature.com/articles/s41...
From Transcriptome to Text
A great LLM-Chatbot explorer for CELLxGENE & GEO & your own data!
Contrastive language image pretraining
Geneformer
BioBERT
>1 million bulk/pseudo-bulk transcriptomes
cellwhisperer.bocklab.org
#NatBiotech 2025
www.nature.com/articles/s41...
Senolytic CAR-T
"Ablation of uPAR+ intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged intestinal stem cells", improves gut barrier integrity & mucosal immune function
bioRxiv 2025
www.biorxiv.org/content/10.1...
"Ablation of uPAR+ intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged intestinal stem cells", improves gut barrier integrity & mucosal immune function
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 21, 2025 at 7:52 PM
Senolytic CAR-T
"Ablation of uPAR+ intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged intestinal stem cells", improves gut barrier integrity & mucosal immune function
bioRxiv 2025
www.biorxiv.org/content/10.1...
"Ablation of uPAR+ intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged intestinal stem cells", improves gut barrier integrity & mucosal immune function
bioRxiv 2025
www.biorxiv.org/content/10.1...
Postnatal Cerebral Perivascular Fibroblast
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
November 21, 2025 at 12:08 PM
Postnatal Cerebral Perivascular Fibroblast
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
November 20, 2025 at 8:10 PM
PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
Beautiful work on renal microvascular mural cells from @ondinecleaver.bsky.social
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
November 20, 2025 at 1:02 PM
Beautiful work on renal microvascular mural cells from @ondinecleaver.bsky.social
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
Inflammatory phenotype of Smooth Muscle Cell needed for Muscular Atherosclerotic Lesion Cap formation
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
November 19, 2025 at 8:06 PM
Inflammatory phenotype of Smooth Muscle Cell needed for Muscular Atherosclerotic Lesion Cap formation
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
#Senescence #Mechanobiology
Human adult lung #Fibroblast undergoes spontaneous #Senescence on soft, viscoelastic hydrogel
Norbornene-modified #HyaluronicAcid▶️
#Stiffness
β-cyclodextrin-modified #HyaluronicAcid▶️
#Viscoelasticity
Likely #YAP independent
bioRxiv 2025
www.biorxiv.org/content/10.1...
Human adult lung #Fibroblast undergoes spontaneous #Senescence on soft, viscoelastic hydrogel
Norbornene-modified #HyaluronicAcid▶️
#Stiffness
β-cyclodextrin-modified #HyaluronicAcid▶️
#Viscoelasticity
Likely #YAP independent
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 19, 2025 at 12:35 PM
#Senescence #Mechanobiology
Human adult lung #Fibroblast undergoes spontaneous #Senescence on soft, viscoelastic hydrogel
Norbornene-modified #HyaluronicAcid▶️
#Stiffness
β-cyclodextrin-modified #HyaluronicAcid▶️
#Viscoelasticity
Likely #YAP independent
bioRxiv 2025
www.biorxiv.org/content/10.1...
Human adult lung #Fibroblast undergoes spontaneous #Senescence on soft, viscoelastic hydrogel
Norbornene-modified #HyaluronicAcid▶️
#Stiffness
β-cyclodextrin-modified #HyaluronicAcid▶️
#Viscoelasticity
Likely #YAP independent
bioRxiv 2025
www.biorxiv.org/content/10.1...
“Time is brain” for cell therapies?🧠
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
November 18, 2025 at 8:07 PM
“Time is brain” for cell therapies?🧠
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Lab-in-the-loop therapeutic antibody design with deep learning
Targets
EGFR
IL6
HER2
OSM
11 lead Ab➡️ 4 rounds with > 3X ⏫binding affinity➡️ > 1800 Ab designs
Hope this system can yield antibodies with better immunohistochemical performance as well
bioRxiv 2025
www.biorxiv.org/content/10.1...
Targets
EGFR
IL6
HER2
OSM
11 lead Ab➡️ 4 rounds with > 3X ⏫binding affinity➡️ > 1800 Ab designs
Hope this system can yield antibodies with better immunohistochemical performance as well
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 18, 2025 at 12:26 PM
Lab-in-the-loop therapeutic antibody design with deep learning
Targets
EGFR
IL6
HER2
OSM
11 lead Ab➡️ 4 rounds with > 3X ⏫binding affinity➡️ > 1800 Ab designs
Hope this system can yield antibodies with better immunohistochemical performance as well
bioRxiv 2025
www.biorxiv.org/content/10.1...
Targets
EGFR
IL6
HER2
OSM
11 lead Ab➡️ 4 rounds with > 3X ⏫binding affinity➡️ > 1800 Ab designs
Hope this system can yield antibodies with better immunohistochemical performance as well
bioRxiv 2025
www.biorxiv.org/content/10.1...
PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
November 17, 2025 at 8:04 PM
PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
Lung morphogenesis🦎 Squamate/Lizards
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
November 17, 2025 at 12:51 PM
Lung morphogenesis🦎 Squamate/Lizards
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
#SmoothMuscleCell m6A Epitranscriptomics
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
November 16, 2025 at 8:34 PM
#SmoothMuscleCell m6A Epitranscriptomics
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:20 PM
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
November 15, 2025 at 11:20 PM
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
November 15, 2025 at 12:17 PM
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
November 14, 2025 at 7:59 PM
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
In vivo two-photon microscopy for studies of #NeuroVascularCoupling in rodents
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
November 14, 2025 at 12:13 PM
In vivo two-photon microscopy for studies of #NeuroVascularCoupling in rodents
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability)
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
November 13, 2025 at 8:02 PM
#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability)
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...