Michael Epstein
@epsteinstatgen.bsky.social
Faculty at Emory Human Genetics, periodically cool dad, typical Boston sports fan (sorry), big believer in Dunning-Kruger effect
Reposted by Michael Epstein
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
September 12, 2025 at 7:00 PM
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
Reposted by Michael Epstein
Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs.
Paper: www.nature.com/articles/s43...
Paper: www.nature.com/articles/s43...
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates - Nature Computational Science
This study introduces a cost-effective strategy called surrogate functional false discovery rates to increase power in genome-wide association studies by leveraging genetic correlations (or pleiotropy...
www.nature.com
August 25, 2025 at 5:04 PM
Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs.
Paper: www.nature.com/articles/s43...
Paper: www.nature.com/articles/s43...
RIP, Prince of Darkness. Arguably in the Top 5 of most influential artists of my lifetime
I truly thought this man was going to live forever, somehow. RIP, Ozzy, you were metal incarnate for me. news.sky.com/story/ozzy-o...
Ozzy Osbourne dies just weeks after farewell show
The heavy metal star reunited with his Black Sabbath bandmates on stage at Villa Park earlier in July.
news.sky.com
July 22, 2025 at 6:46 PM
RIP, Prince of Darkness. Arguably in the Top 5 of most influential artists of my lifetime
Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!
🚨New method!
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑🤝🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑🤝🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co
CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
CADET is a transcriptome-wide association test for admixed cohorts that leverages
local ancestry information to improve detection of trait-influencing genes. CADET
outperformed existing methods using ...
www.cell.com
June 23, 2025 at 12:33 PM
Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!
Reposted by Michael Epstein
Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!
Submission deadline is June 8th, conference July 6-11th.
Submission deadline is June 8th, conference July 6-11th.
April 19, 2025 at 12:49 AM
Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!
Submission deadline is June 8th, conference July 6-11th.
Submission deadline is June 8th, conference July 6-11th.
Reposted by Michael Epstein
Multiple Postdoc Positions available in Epidemiology, Biostatistics, or Statistical Genetics (deadline April 15)
Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark!
#Postdoc #Epidemiology #StatisticalGenetics #Biostatistics
👉 international.au.dk/about/profil...
Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark!
#Postdoc #Epidemiology #StatisticalGenetics #Biostatistics
👉 international.au.dk/about/profil...
Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University
Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University
international.au.dk
March 25, 2025 at 2:02 PM
Multiple Postdoc Positions available in Epidemiology, Biostatistics, or Statistical Genetics (deadline April 15)
Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark!
#Postdoc #Epidemiology #StatisticalGenetics #Biostatistics
👉 international.au.dk/about/profil...
Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark!
#Postdoc #Epidemiology #StatisticalGenetics #Biostatistics
👉 international.au.dk/about/profil...
Reposted by Michael Epstein
Happy Chrismukkah to all the delightful half-half situations (like me)
December 25, 2024 at 2:36 PM
Happy Chrismukkah to all the delightful half-half situations (like me)
Reposted by Michael Epstein
For those working in pathway and co-expression analysis, check out Andy’s recent preprint describing a more powerful and flexible framework for such studies!
Differential co-expression arises from shared unmodeled biological variation involving an observed risk factor and an unobserved (or latent) factor. We developed a method to detect such variation in a pathway for general gene expression studies!
A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1
December 4, 2024 at 2:16 PM
For those working in pathway and co-expression analysis, check out Andy’s recent preprint describing a more powerful and flexible framework for such studies!
Reposted by Michael Epstein
We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky
November 29, 2024 at 4:26 PM
We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky
Reposted by Michael Epstein
I'm developing a pipeline to call CHIP mutations in UK Biobank using the DNA Nexus RAP that is fast/cheap/reproducible. Initial results are promising; calls looks reasonable and cost to do this across all of UKB is likely < 500$.
Feel free to DM if of interest.
Feel free to DM if of interest.
November 22, 2024 at 10:17 PM
I'm developing a pipeline to call CHIP mutations in UK Biobank using the DNA Nexus RAP that is fast/cheap/reproducible. Initial results are promising; calls looks reasonable and cost to do this across all of UKB is likely < 500$.
Feel free to DM if of interest.
Feel free to DM if of interest.
Reposted by Michael Epstein
Finally a VP who’s had to design a syllabus!
August 6, 2024 at 1:13 PM
Finally a VP who’s had to design a syllabus!
Excited to share our method LIT; a kernel approach to map genetic variants with interaction effects on multiple phenotypes in biobanks. R package implementing the method available on CRAN. Kudos to Andy Bass for leading this work!
genomemedicine.biomedcentral.com/articles/10....
genomemedicine.biomedcentral.com/articles/10....
Identifying latent genetic interactions in genome-wide association studies using multiple traits - Genome Medicine
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a n...
genomemedicine.biomedcentral.com
May 1, 2024 at 12:21 PM
Excited to share our method LIT; a kernel approach to map genetic variants with interaction effects on multiple phenotypes in biobanks. R package implementing the method available on CRAN. Kudos to Andy Bass for leading this work!
genomemedicine.biomedcentral.com/articles/10....
genomemedicine.biomedcentral.com/articles/10....
Reposted by Michael Epstein
CHARLIE BROWN: Can I kick it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I *kick* it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I _kick_ it.
LUCY: Yes, you can!
CHARLIE BROWN: {running toward ball} Well, I’m gone!
LUCY: {pulling the ball away} Gone!
LUCY: Yes, you can!
CHARLIE BROWN: Can I *kick* it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I _kick_ it.
LUCY: Yes, you can!
CHARLIE BROWN: {running toward ball} Well, I’m gone!
LUCY: {pulling the ball away} Gone!
November 14, 2023 at 4:37 PM
CHARLIE BROWN: Can I kick it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I *kick* it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I _kick_ it.
LUCY: Yes, you can!
CHARLIE BROWN: {running toward ball} Well, I’m gone!
LUCY: {pulling the ball away} Gone!
LUCY: Yes, you can!
CHARLIE BROWN: Can I *kick* it?
LUCY: Yes, you can!
CHARLIE BROWN: Can I _kick_ it.
LUCY: Yes, you can!
CHARLIE BROWN: {running toward ball} Well, I’m gone!
LUCY: {pulling the ball away} Gone!
Reposted by Michael Epstein
Please be sure to check you kid's candy this year. I just found another project I have no time for in a Reese's cup
October 31, 2023 at 1:48 PM
Please be sure to check you kid's candy this year. I just found another project I have no time for in a Reese's cup
Reposted by Michael Epstein
Preprint is up now www.biorxiv.org/content/10.1...
October 21, 2023 at 1:44 PM
Preprint is up now www.biorxiv.org/content/10.1...
Reposted by Michael Epstein
Trying to be better with sharing work on here 😅
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1
Glioma is a highly fatal brain tumor comprised of molecular subtypes with distinct clinical trajecto
www.medrxiv.org
October 16, 2023 at 5:51 PM
Trying to be better with sharing work on here 😅
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Reposted by Michael Epstein
👋 Hi genetics/statgen/gen-epi trainees! 🧬 🧪
If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!
If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!
October 3, 2023 at 5:07 PM
👋 Hi genetics/statgen/gen-epi trainees! 🧬 🧪
If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!
If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!
Pep and jazz band member
Latin Club member who also took Ancient Greek
Listened to Rush 24/7.
I checked all the boxes
Latin Club member who also took Ancient Greek
Listened to Rush 24/7.
I checked all the boxes
I can’t imagine any Bsky early adopter was cool in high school, so what kind of loser were you?
October 1, 2023 at 3:39 PM
Pep and jazz band member
Latin Club member who also took Ancient Greek
Listened to Rush 24/7.
I checked all the boxes
Latin Club member who also took Ancient Greek
Listened to Rush 24/7.
I checked all the boxes
Reposted by Michael Epstein
bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...
September 28, 2023 at 2:27 PM
bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...
Introducing some cool work by @ajbass.bsky.social in my lab for detecting genetic variants with interactive effects on phenotypes of interest in biobanks leveraging pleiotropy. Hope you find it interesting!
A preprint of my first post-doc paper w/ Shijia Bian, Aliza Wingo, Thomas Wingo, David Cutler and @epsteinstatgen.bsky.social is out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Identifying latent genetic interactions in genome-wide association studies using multiple traits
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 15, 2023 at 7:18 PM
Introducing some cool work by @ajbass.bsky.social in my lab for detecting genetic variants with interactive effects on phenotypes of interest in biobanks leveraging pleiotropy. Hope you find it interesting!
Just curious; what is the longest wait time anyone has experienced for a desk rejection?
September 12, 2023 at 12:06 AM
Just curious; what is the longest wait time anyone has experienced for a desk rejection?
Reposted by Michael Epstein
GWAS of antimullerian hormone (AMH) levels in the Finnish population. One of the hits is CHEK2 driven by a loss of function variant that is 4x enriched in Finland.
Pujol-Gualdo et al. medRxiv
www.medrxiv.org/content/10.1...
Pujol-Gualdo et al. medRxiv
www.medrxiv.org/content/10.1...
September 9, 2023 at 4:13 PM
GWAS of antimullerian hormone (AMH) levels in the Finnish population. One of the hits is CHEK2 driven by a loss of function variant that is 4x enriched in Finland.
Pujol-Gualdo et al. medRxiv
www.medrxiv.org/content/10.1...
Pujol-Gualdo et al. medRxiv
www.medrxiv.org/content/10.1...
My latest cure for writer’s block
August 28, 2023 at 5:56 PM
My latest cure for writer’s block
@danirabaiotti.bsky.social : could I please be added to the science feed? Thanks so much!
August 10, 2023 at 1:46 AM
@danirabaiotti.bsky.social : could I please be added to the science feed? Thanks so much!