Lightnews — Scholar-powered news

Nicholas Mancuso

@nmancuso.bsky.social

1.4K followers 1.1K following 930 posts

Associate Professor at USC. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine. www.mancusolab.com

Posts Media Videos Starter Packs

Pinned

Nicholas Mancuso @nmancuso.bsky.social · Nov 17

Who dares to disturb my slumber

a cartoon character with a skull on his face

ALT: a cartoon character with a skull on his face

media.tenor.com

Reposted by Nicholas Mancuso

The Fig Economy @figgityfigs.bsky.social · 3h

Yeah, a bunch of people predisposed to authoritarianism without sufficient theory of mind to understand that their opponents are not.

2 2 100

Nicholas Mancuso @nmancuso.bsky.social · 16h

Not ghost pepper. I think maybe pequin? They were from a neighbor, that I dried and took seeds from.

Nicholas Mancuso @nmancuso.bsky.social · 21h

Another week or so until they're ready, I think. My first time growing these from seeds.

Nicholas Mancuso @nmancuso.bsky.social · 21h

Peppers incoming 🌶️

2 1 8

Reposted by Nicholas Mancuso

Andy Craig @andycraig.bsky.social · 1d

Basically half the world's air forces do training in the US. Dozens of countries. It's been a big thing for a long time. At any given time there are lots of them in the US at various bases. We effectively are their training academies on the planes and weapons we sell them. It's not a novel thing.

39 47 250

Reposted by Nicholas Mancuso

Anne Carpenter @drannecarpenter.bsky.social · 2d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

24 140 390

Reposted by Nicholas Mancuso

Jessica Kant @jessdkant.bsky.social · 2d

So when I hear of students being encouraged to use GPT in college I don’t hear innovation. I hear cognitive atrophy, the inability to think critically for oneself, and total dependence on vulnerable centralized repositories of data for knowledge without ever understanding how knowledge is generated.

10 160 770

Nicholas Mancuso @nmancuso.bsky.social · 1d

Just arrived this week direct from CSH. Looking forward to reading!

1 1

Reposted by Nicholas Mancuso

John Greally @greally.bsky.social · 1d

My book on Epigenetics: History, Molecules and Diseases

www.amazon.com/Epigenetics-...

#EpigeneticsBook #Epigenetics

Epigenetics: History, Molecules, and Diseases

Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders

www.amazon.com

1 2 10

Reposted by Nicholas Mancuso

Human Genetics and Genomics Advances @hggadvances.bsky.social · 1d

Will you be at #ASHG25 next week? Come chat each day 3-4pm at ASHG Central!

2 4

Nicholas Mancuso @nmancuso.bsky.social · 1d

YES LFG

CalMatters @calmatters.org · 2d

After weeks of waiting, California's governor signed a bill that will allow mid-rise apartment buildings near major transit stops in California's biggest metro areas. https://cal.news/4n3hzge

📝 @frombenc.bsky.social
📸 Ray Chavez

Passengers look on as a BART train didn’t stop at the Rockridge BART station due to a systemwide closure that affected all BART stations, in Oakland on March 9, 2025. Photo by Ray Chavez, Bay Area News Group

Hed: Breaking: Gov. Newsom signs massive California housing overhaul

Reposted by Nicholas Mancuso

Kerstin Ludwig @kuludwig.bsky.social · 2d

I finally made (it on) my first cover 🤣 🥳!!
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.

Human Genetics and Genomics Advances @hggadvances.bsky.social · 3d

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

3 5

Nicholas Mancuso @nmancuso.bsky.social · 2d

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.

Please consider submitting your work in genetics/genomics with us!

Human Genetics and Genomics Advances @hggadvances.bsky.social · 3d

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

5 7

Reposted by Nicholas Mancuso

Alan Burdick @alanburdick.bsky.social · 3d

A new NYT as-told-to series, "Lost Science," documents the work of researchers who have lost their jobs or funding after cuts by the Trump administration. Share your story with us!

www.nytimes.com/2025/10/08/c...

Has Your Scientific Work Been Cut? We Want to Hear.

www.nytimes.com

4 53 110

Reposted by Nicholas Mancuso

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 3d

PEQG website live! genetics-gsa.org/peqg-2026/

Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

22 38

Reposted by Nicholas Mancuso

Inigo Martincorena @imartincorena.bsky.social · 4d

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

5 44 86

Nicholas Mancuso @nmancuso.bsky.social · 3d

Which bars, I need these bars

1 1

Nicholas Mancuso @nmancuso.bsky.social · 3d

Tax incentives for folks who have children directly support those children bc, again, kids cannot work. Comparing children to owning property says more about you than any other weird links u try to dredge up

1 2

Nicholas Mancuso @nmancuso.bsky.social · 4d

There was some standup that popped into my insta feed that was similar to this. "I wike peanut butter n beef. Wanna see my muscles?" Can't seem to find it, but the 6-year old voice sold it.

Reposted by Nicholas Mancuso

Nicole Chung @nicolechung.bsky.social · 4d

Young lives cut short on an unimaginable scale: the 18,457 children on Gaza’s list of war dead

Every name on a list compiled by health authorities in Gaza of the child victims of Israel’s offensive

www.theguardian.com

11 30

Reposted by Nicholas Mancuso

April Wei @aprilwei.bsky.social · 4d

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Inference of complex demographic history using composite likelihood based on whole-genome genealogies

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

www.biorxiv.org

1 23 45

Reposted by Nicholas Mancuso

April Wei @aprilwei.bsky.social · 4d

Method works from simple and complex scenarios in jointly estimating epoch time, population size, migration rate (symmetric or asymmetric), growth rate, and admixture proportion. Software integrated with msprime, demes, tsinfer/tsdate, relate, and singer. github.com/aprilweilab/...

4 4

Nicholas Mancuso @nmancuso.bsky.social · 4d

Hey Tom, do children incur extra financial costs? Also, can children work? Thx.

1 1

Reposted by Nicholas Mancuso

PUMPKIN SPICE SLUGGO @saintsluggo.bsky.social · 4d

Holy shit, AI can do my job after all. I work in retail and I lie to people all the time to make them stop bothering me.

1 1 9

Reposted by Nicholas Mancuso

ghost malone ergo propter malone @proptermalone.bsky.social · 4d

New Normal Men! @golikehellmachine.com returns to tell us about Portland, we break down the shutdown, and @ed3d.net talks @rickywlmsbong.bsky.social into buying Hades 2.

Episode 27 - Frog in the Streets and a Freak in the Sheets

Podcast Episode · Normal Men · 10/08/2025 · 1h 2m

podcasts.apple.com

9 28 130