Dr Laura McCulloch
@dr-l-mcculloch.bsky.social
Principal investigator at the University of Edinburgh.
Research on the systemic immune response to stroke and complications of stroke recovery. #Bcells #infection #GIdysfunction #cognitivedecline
Wellcome Sir Henry Dale fellow
Research on the systemic immune response to stroke and complications of stroke recovery. #Bcells #infection #GIdysfunction #cognitivedecline
Wellcome Sir Henry Dale fellow
Pinned
www.biorxiv.org
🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
Not long to go until #BSI25
For neuroimmunology enthusiasts, please come to our double session "Neuroimmunology across the body" on Wed 3rd jointly hosted by the Neuroimmunology Affinity Group and Wessex Immunology Group
For neuroimmunology enthusiasts, please come to our double session "Neuroimmunology across the body" on Wed 3rd jointly hosted by the Neuroimmunology Affinity Group and Wessex Immunology Group
November 26, 2025 at 12:12 PM
Not long to go until #BSI25
For neuroimmunology enthusiasts, please come to our double session "Neuroimmunology across the body" on Wed 3rd jointly hosted by the Neuroimmunology Affinity Group and Wessex Immunology Group
For neuroimmunology enthusiasts, please come to our double session "Neuroimmunology across the body" on Wed 3rd jointly hosted by the Neuroimmunology Affinity Group and Wessex Immunology Group
Reposted by Dr Laura McCulloch
New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk.
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions
Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…
www.sciencedirect.com
November 22, 2025 at 1:12 PM
New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk.
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
I am pleased to offer another PhD opportunity supervised by myself and @joyedwardshicks.bsky.social Here we will investigate how neural signals regulate adaptive immune responses
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
EASTBIO - Investigating how neural signalling regulates adaptive immune responses at University of Edinburgh on FindAPhD.com
PhD Project - EASTBIO - Investigating how neural signalling regulates adaptive immune responses at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 21, 2025 at 9:28 AM
I am pleased to offer another PhD opportunity supervised by myself and @joyedwardshicks.bsky.social Here we will investigate how neural signals regulate adaptive immune responses
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
We are looking for a PhD. student to work with us on our investigation into immune suppression and infection vulnerability after stroke. This project will focus on the lung immune environment and therapeutic interventions to improve infection clearance.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh on FindAPhD.com
PhD Project - Understanding pneumonia vulnerability in stroke recovery at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
October 28, 2025 at 8:19 PM
We are looking for a PhD. student to work with us on our investigation into immune suppression and infection vulnerability after stroke. This project will focus on the lung immune environment and therapeutic interventions to improve infection clearance.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Dr Laura McCulloch
Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix).
🔬 Focus: chemokines, glycocalyx & inflammatory disease
📍 Cutting-edge biochem, biophysics & in vivo biology
Apply now 👉 shorturl.at/jEQ6G
🔬 Focus: chemokines, glycocalyx & inflammatory disease
📍 Cutting-edge biochem, biophysics & in vivo biology
Apply now 👉 shorturl.at/jEQ6G
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
shorturl.at
September 18, 2025 at 9:27 AM
Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix).
🔬 Focus: chemokines, glycocalyx & inflammatory disease
📍 Cutting-edge biochem, biophysics & in vivo biology
Apply now 👉 shorturl.at/jEQ6G
🔬 Focus: chemokines, glycocalyx & inflammatory disease
📍 Cutting-edge biochem, biophysics & in vivo biology
Apply now 👉 shorturl.at/jEQ6G
Reposted by Dr Laura McCulloch
🚨 The Menon lab is hiring a postdoc!
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Mucosal Immunology :Manchester
www.jobs.manchester.ac.uk
June 20, 2025 at 3:13 PM
🚨 The Menon lab is hiring a postdoc!
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social
Please help spread the word #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Dr Laura McCulloch
Explore new research on #Neuroimmunology & #Neurodegeneration, incl. macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...
#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social
#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social
June 13, 2025 at 2:31 PM
Explore new research on #Neuroimmunology & #Neurodegeneration, incl. macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...
#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social
#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social
Reposted by Dr Laura McCulloch
Please join us for the summer EIG mini symposium on Tuesday 17th of June. The session starts at 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 with talks by Prof Simon Graham, Dr Kate Sutton and Prof Christoph Scheiermann. See you there!
June 2, 2025 at 4:05 PM
Please join us for the summer EIG mini symposium on Tuesday 17th of June. The session starts at 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 with talks by Prof Simon Graham, Dr Kate Sutton and Prof Christoph Scheiermann. See you there!
Reposted by Dr Laura McCulloch
Now online! Macrophages direct location-dependent recall of B cell memory to vaccination
Macrophages direct location-dependent recall of B cell memory to vaccination
Subcapsular sinus macrophages in the draining lymph node help retain resident memory B cells in the subcapsular niche and promote their re-entry into secondary germinal centers. Boosting vaccines in the same arm leads to more rapid secretion of broadly neutralizing antibodies.
dlvr.it
April 29, 2025 at 12:41 PM
Now online! Macrophages direct location-dependent recall of B cell memory to vaccination
🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org
April 29, 2025 at 10:05 AM
🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org/content/10.1...
Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
Reposted by Dr Laura McCulloch
The spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!
April 28, 2025 at 6:23 AM
The spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!
Reposted by Dr Laura McCulloch
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
April 28, 2025 at 7:42 AM
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
Reposted by Dr Laura McCulloch
'The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
March 30, 2025 at 9:16 AM
'The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Dr Laura McCulloch
Heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...
March 11, 2025 at 4:56 PM
Heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...
Reposted by Dr Laura McCulloch
Reposted by Dr Laura McCulloch
Stoler-Barak, @zivshulman.bsky.social et al. show that SMARCA5-mediated #chromatin remodeling is required for germinal center formation rupress.org/jem/article/...
📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25
📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25
March 4, 2025 at 4:10 PM
Stoler-Barak, @zivshulman.bsky.social et al. show that SMARCA5-mediated #chromatin remodeling is required for germinal center formation rupress.org/jem/article/...
📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25
📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25
Reposted by Dr Laura McCulloch
Our new collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation & dysfunction leading to lymphoma development. Read new research accompanying @keystonesymposia.bsky.social on Multifaceted B Cell Functions & Dysfunctions: https://buff.ly/3CX1Y0O
#KSBCells25
#KSBCells25
February 26, 2025 at 3:15 PM
Our new collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation & dysfunction leading to lymphoma development. Read new research accompanying @keystonesymposia.bsky.social on Multifaceted B Cell Functions & Dysfunctions: https://buff.ly/3CX1Y0O
#KSBCells25
#KSBCells25
Reposted by Dr Laura McCulloch
🚨 We have TWO exciting open positions in our lab! 🚨
We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:
🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...
💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...
📢 Please share!
We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:
🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...
💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...
📢 Please share!
Research Assistant (177885)
We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.
www.kennedy.ox.ac.uk
February 24, 2025 at 11:35 AM
🚨 We have TWO exciting open positions in our lab! 🚨
We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:
🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...
💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...
📢 Please share!
We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:
🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...
💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...
📢 Please share!
Reposted by Dr Laura McCulloch
Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.
Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.
www.frontiersin.org/journals/imm...
Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.
www.frontiersin.org/journals/imm...
Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome
www.frontiersin.org
February 17, 2025 at 7:23 AM
Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.
Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.
www.frontiersin.org/journals/imm...
Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.
www.frontiersin.org/journals/imm...
First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
February 20, 2025 at 3:14 PM
First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...