Riccardo Capecchi
@blepiro.bsky.social
MD, PhD. Clinical Immunologist hidden inside an Internist. Sssshhhh. #medsky #immunosky #rheumatology
Pinned
Riccardo Capecchi
@blepiro.bsky.social
· Nov 25
The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease - PubMed
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work...
pmid.us
Our online free tool helps you perform a classification of an IgG4-RD patient according to the 2019 ACR/EuLAR classification criteria for IgG4-RD (pmid.us/31796497).
Give it a try!
davte.it/IgG4-RD.html
(Courtesy of Dr Davide Testa)
#IgG4-RD #RheumSky
Give it a try!
davte.it/IgG4-RD.html
(Courtesy of Dr Davide Testa)
#IgG4-RD #RheumSky
Reposted by Riccardo Capecchi
Hey @nature.com, have you got an explanation for how the hell THIS happened? & especially why you accepted a paper with such a bizarre piece of genAI slop in it?!
& more to the point, why we should take you seriously at all going forward?
www.nature.com/articles/s41...
& more to the point, why we should take you seriously at all going forward?
www.nature.com/articles/s41...
November 27, 2025 at 3:03 PM
Hey @nature.com, have you got an explanation for how the hell THIS happened? & especially why you accepted a paper with such a bizarre piece of genAI slop in it?!
& more to the point, why we should take you seriously at all going forward?
www.nature.com/articles/s41...
& more to the point, why we should take you seriously at all going forward?
www.nature.com/articles/s41...
Reposted by Riccardo Capecchi
#Medsky🧪#Neurosky @jama.com
#Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair…
jamanetwork.com/journals/jam...
#Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair…
jamanetwork.com/journals/jam...
Peripheral Neuropathy: A Review
This review discusses the pathophysiology, clinical presentation, diagnosis, and treatment of length-dependent peripheral neuropathy.
jamanetwork.com
November 22, 2025 at 6:14 AM
#Medsky🧪#Neurosky @jama.com
#Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair…
jamanetwork.com/journals/jam...
#Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair…
jamanetwork.com/journals/jam...
Reposted by Riccardo Capecchi
November 18, 2025 at 4:00 PM
Reposted by Riccardo Capecchi
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
November 17, 2025 at 10:31 PM
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
It's starting the AIpocalypse
Billionaire Peter Thiel’s latest 13F didn’t show off a mere trim, but a full-blown exit from AI bellwether Nvidia (NVDA).
November 17, 2025 at 5:21 AM
It's starting the AIpocalypse
Reposted by Riccardo Capecchi
just sharing here as I was reminded it's on github, in case people wanna make copies: github.com/oliviaguest/...
the cogsci hexagon: A visual depiction of the connections between the Cognitive Sciences
the cogsci hexagon: A visual depiction of the connections between the Cognitive Sciences
November 16, 2025 at 2:16 PM
just sharing here as I was reminded it's on github, in case people wanna make copies: github.com/oliviaguest/...
the cogsci hexagon: A visual depiction of the connections between the Cognitive Sciences
the cogsci hexagon: A visual depiction of the connections between the Cognitive Sciences
Reposted by Riccardo Capecchi
sts researchers: :spend decades tracing the way well-intentioned design choices constrained by culture, capital, and the material environment can have negative outcomes in aggregate:
ai companies: lets put a chatbot in a doll that tells kids to set fires
futurism.com/artificial-i...
ai companies: lets put a chatbot in a doll that tells kids to set fires
futurism.com/artificial-i...
AI-Powered Toys Caught Telling 5-Year-Olds How to Find Knives and Start Fires With Matches
AI-powered toys are flying off the shelves -- but they're engaging in horrifically inappropriate conversations with children.
futurism.com
November 13, 2025 at 2:34 PM
sts researchers: :spend decades tracing the way well-intentioned design choices constrained by culture, capital, and the material environment can have negative outcomes in aggregate:
ai companies: lets put a chatbot in a doll that tells kids to set fires
futurism.com/artificial-i...
ai companies: lets put a chatbot in a doll that tells kids to set fires
futurism.com/artificial-i...
Reposted by Riccardo Capecchi
All our articles with @irisvanrooij.bsky.social and others are collected here too olivia.science/ai
Critical AI
On this page are some resources for Critical AI Literacy (CAIL) from my perspective.
olivia.science
November 14, 2025 at 4:22 PM
All our articles with @irisvanrooij.bsky.social and others are collected here too olivia.science/ai
Reposted by Riccardo Capecchi
Reposted by Riccardo Capecchi
Thrilled that this work is (finally) out! We argue that the human brain contains parallel systems for understanding people and places.
www.pnas.org/doi/10.1073/... 1/
www.pnas.org/doi/10.1073/... 1/
November 11, 2025 at 10:20 PM
Thrilled that this work is (finally) out! We argue that the human brain contains parallel systems for understanding people and places.
www.pnas.org/doi/10.1073/... 1/
www.pnas.org/doi/10.1073/... 1/
Reposted by Riccardo Capecchi
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
November 10, 2025 at 6:14 PM
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
Reposted by Riccardo Capecchi
Before ACA, many Americans couldn’t afford insurance
Alex Smith was a diabetic who got kicked off his Mom’s insurance at 26
He made 35k a year which was “too much” for Medicaid, but not nearly enough to cover insurance premiums
He had to ration his insulin & died a month after losing insurance
Alex Smith was a diabetic who got kicked off his Mom’s insurance at 26
He made 35k a year which was “too much” for Medicaid, but not nearly enough to cover insurance premiums
He had to ration his insulin & died a month after losing insurance
Insulin's High Cost Leads To Lethal Rationing
Alec Raeshawn Smith was 23 when diagnosed with Type 1 diabetes and 26 when he died. He couldn't afford $1,300 per month for his insulin and other diabetes supplies, so he tried to stretch the doses.
www.npr.org
November 10, 2025 at 5:01 AM
Before ACA, many Americans couldn’t afford insurance
Alex Smith was a diabetic who got kicked off his Mom’s insurance at 26
He made 35k a year which was “too much” for Medicaid, but not nearly enough to cover insurance premiums
He had to ration his insulin & died a month after losing insurance
Alex Smith was a diabetic who got kicked off his Mom’s insurance at 26
He made 35k a year which was “too much” for Medicaid, but not nearly enough to cover insurance premiums
He had to ration his insulin & died a month after losing insurance
Reposted by Riccardo Capecchi
Earlier this year, we released a special issue titled “The Unraveling of Space-Time.” We cover black holes, holograms, and “alien algebra.” Explore the series:
The Unraveling of Space-Time | Quanta Magazine
This special issue of Quanta Magazine explores the ultimate scientific quest: the search for the fundamental nature of reality.
www.quantamagazine.org
November 9, 2025 at 9:04 PM
Earlier this year, we released a special issue titled “The Unraveling of Space-Time.” We cover black holes, holograms, and “alien algebra.” Explore the series:
Reposted by Riccardo Capecchi
I have somehow never read Breakfast of Champions and holy hell in three pages Vonnegut sums it all up - colonialism, racism, income inequality, and a guy who owns a car dealership who reads a scifi novel and takes away the wrong idea
November 8, 2025 at 5:40 PM
I have somehow never read Breakfast of Champions and holy hell in three pages Vonnegut sums it all up - colonialism, racism, income inequality, and a guy who owns a car dealership who reads a scifi novel and takes away the wrong idea
Reposted by Riccardo Capecchi
Breaking news: US stocks have dropped as jitters over highly elevated valuations for many artificial intelligence companies intensified and top Wall Street executives said markets were vulnerable to a pullback. on.ft.com/4hIMmhj
November 4, 2025 at 9:12 PM
Breaking news: US stocks have dropped as jitters over highly elevated valuations for many artificial intelligence companies intensified and top Wall Street executives said markets were vulnerable to a pullback. on.ft.com/4hIMmhj
Reposted by Riccardo Capecchi
"A good way to learn German is to read children's books to familiarise yourself with basic grammar and vocabulary"
German children's book:
German children's book:
December 10, 2024 at 6:58 AM
"A good way to learn German is to read children's books to familiarise yourself with basic grammar and vocabulary"
German children's book:
German children's book:
Reposted by Riccardo Capecchi
We are excited to share our recent results on a new lncrna that functions to regulate proliferation in thp1 cells. This is the thesis work of Christy Montano.
CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, INSTAR, in Human Monocytes https://www.biorxiv.org/content/10.1101/2025.10.30.685589v1
November 2, 2025 at 12:57 AM
We are excited to share our recent results on a new lncrna that functions to regulate proliferation in thp1 cells. This is the thesis work of Christy Montano.
Reposted by Riccardo Capecchi
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Phagocytosis: a process that shapes immune responses to engulfed meals
Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...
rdcu.be
October 31, 2025 at 7:22 PM
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Reposted by Riccardo Capecchi
#Medssky🧪 #IDsky #immunosky #Publichealth The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination.
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses
The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vac…
www.sciencedirect.com
October 27, 2025 at 5:14 AM
#Medssky🧪 #IDsky #immunosky #Publichealth The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination.
Reposted by Riccardo Capecchi
A microscopic organism can survive the vacuum of space: yet our infrastructures collapse under a summer storm.
Why? 👉 Because structure isn’t enough.
Resilience depends on functionality.
And we need a lot of network science to grasp it.
📖 manlius.substack.com/p/making-sen...
#ComplexityThoughts
Why? 👉 Because structure isn’t enough.
Resilience depends on functionality.
And we need a lot of network science to grasp it.
📖 manlius.substack.com/p/making-sen...
#ComplexityThoughts
Making sense of complex systems functionality
What slime molds, neural systems and quantum physics have in common?
manlius.substack.com
October 26, 2025 at 9:34 AM
A microscopic organism can survive the vacuum of space: yet our infrastructures collapse under a summer storm.
Why? 👉 Because structure isn’t enough.
Resilience depends on functionality.
And we need a lot of network science to grasp it.
📖 manlius.substack.com/p/making-sen...
#ComplexityThoughts
Why? 👉 Because structure isn’t enough.
Resilience depends on functionality.
And we need a lot of network science to grasp it.
📖 manlius.substack.com/p/making-sen...
#ComplexityThoughts
Reposted by Riccardo Capecchi
#Medsky🧪 #IDsky #Neurosky #Immunosky #publichealth Studies in 🐁 & 33 AD patients . The researchers suggests that brain cholesterol deficiency can significantly contribute to the initiation & progression of #Alzheimer’sdisease (AD).
October 26, 2025 at 5:08 AM
#Medsky🧪 #IDsky #Neurosky #Immunosky #publichealth Studies in 🐁 & 33 AD patients . The researchers suggests that brain cholesterol deficiency can significantly contribute to the initiation & progression of #Alzheimer’sdisease (AD).
Reposted by Riccardo Capecchi
A Review of auto-Abs neutralizing type I IFN in patients with arboviral diseases:
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases | Journal of Human Immunity | Rockefeller University Press
Autoantibodies neutralizing antiviral type I IFNs (AAN-I-IFN) underlie a small but growing number of severe arboviral diseases. These auto-Abs are strong,
rupress.org
October 24, 2025 at 1:19 PM
A Review of auto-Abs neutralizing type I IFN in patients with arboviral diseases:
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Reposted by Riccardo Capecchi
So I realize I’ve reposted this all day, but I cannot understate the scale of this story. If Anthropic is spending this much on Google Cloud - or even 25% - the costs of running their business are never coming down. It’s a huge scoop, and the first real discussion of the true costs of AI anywhere.
Exclusive: Anthropic spent $2.66 billion on Amazon Web Services in the first three quarters of 2025, around 100% of their estimated revenue. Its costs appear to increase with their revenue, showing little path to profitability.
www.wheresyoured.at/costs/
www.wheresyoured.at/costs/
This Is How Much Anthropic and Cursor Spend On Amazon Web Services
So, I originally planned for this to be on my premium newsletter, but decided it was better to publish on my free one so that you could all enjoy it. If you liked it, please consider subscribing to su...
www.wheresyoured.at
October 21, 2025 at 2:37 AM
So I realize I’ve reposted this all day, but I cannot understate the scale of this story. If Anthropic is spending this much on Google Cloud - or even 25% - the costs of running their business are never coming down. It’s a huge scoop, and the first real discussion of the true costs of AI anywhere.
Reposted by Riccardo Capecchi
Here are two "I can't believe these are free" online stats texts books that cover both underlying principles and practical applications in R that I regularly refer to.
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
October 17, 2025 at 8:43 AM
Here are two "I can't believe these are free" online stats texts books that cover both underlying principles and practical applications in R that I regularly refer to.
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Learning Statistics with R
learningstatisticswithr.com
Doing Meta-Analysis with R bookdown.org/MathiasHarre...
Reposted by Riccardo Capecchi
Proud papa moment: my son J published a letter in the @nytimes.com today (in print tomorrow) on the need to think our definitions of autism.
October 18, 2025 at 8:06 PM
Proud papa moment: my son J published a letter in the @nytimes.com today (in print tomorrow) on the need to think our definitions of autism.