BaumjohannLab
@baumjohannlab.bsky.social
Research on T and B cells in immunity and autoimmunity in the lab of Dirk Baumjohann at University Hospital Bonn & Cluster of Excellence ImmunoSensation @immunosens.bsky.social #TfhCells #GCs #ImmuneOrganoids
https://BaumjohannLab.de
https://BaumjohannLab.de
Pinned
BaumjohannLab
@baumjohannlab.bsky.social
· Mar 12
Boosting human immunology: harnessing the potential of immune organoids | EMBO Molecular Medicine
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
Awesome cover art featuring my lab's recent review on human immune organoids (with @maximilianmoll.bsky.social) published in @embomolmed.org www.embopress.org/doi/full/10.... It was great working together with @teresasteffen.bsky.social and @drawimpacts.bsky.social on creating such a cool image!
Reposted by BaumjohannLab
The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
November 20, 2025 at 10:54 AM
The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
Reposted by BaumjohannLab
November 18, 2025 at 4:00 PM
Reposted by BaumjohannLab
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by BaumjohannLab
Registration is open for the Spring School on Immunology, hosted by DGfI
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
November 11, 2025 at 5:48 PM
Registration is open for the Spring School on Immunology, hosted by DGfI
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
Reposted by BaumjohannLab
ICYMI: Engineering and biofabrication of early cancer models
Engineering and biofabrication of early cancer models
Nature Reviews Bioengineering, Published online: 03 November 2025; doi:10.1038/s44222-025-00371-wEarly cancer biology and detection research is limited owing to a lack of clinical samples from pre-malignant and early-stage tumours. This Review discusses engineered in vitro systems that mimic early disease stages to investigate tumour progression and identify biomarkers for early cancer detection.
www.nature.com
November 4, 2025 at 4:43 PM
ICYMI: Engineering and biofabrication of early cancer models
Reposted by BaumjohannLab
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
November 6, 2025 at 2:48 AM
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
Reposted by BaumjohannLab
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
November 5, 2025 at 6:24 PM
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
Reposted by BaumjohannLab
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907
#RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.: 089/2025 Starting date: As soon as possible. The con...
www.nature.com
October 27, 2025 at 9:55 PM
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Reposted by BaumjohannLab
Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
October 21, 2025 at 5:01 PM
Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
Reposted by BaumjohannLab
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 13, 2025 at 1:30 PM
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Reposted by BaumjohannLab
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 10, 2025 at 7:22 PM
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by BaumjohannLab
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
October 9, 2025 at 11:00 AM
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Reposted by BaumjohannLab
Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
How do cytokines tune immune helpers?
Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity.
🔗 www.nature.com/articles/s41...
#Immunology #SpatialBiology
Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity.
🔗 www.nature.com/articles/s41...
#Immunology #SpatialBiology
October 9, 2025 at 9:54 AM
Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Reposted by BaumjohannLab
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
October 8, 2025 at 5:17 PM
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
Reposted by BaumjohannLab
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Reposted by BaumjohannLab
The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
The official website of the Nobel Prize - NobelPrize.org
The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.
www.nobelprize.org
October 6, 2025 at 9:48 AM
The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Reposted by BaumjohannLab
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Reposted by BaumjohannLab
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 3, 2025 at 6:07 PM
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
Reposted by BaumjohannLab
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby
neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance.
This otherwise imperceptible immun...
www.cell.com
October 2, 2025 at 4:50 PM
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Reposted by BaumjohannLab
Amyotrophic lateral sclerosis is associated with autoimmune CD4 T cell recognition of C9orf72 & release of IL-5 and IL-10, w/ IL-10 correlating with longer survival
www.nature.com/articles/s41... @nature.com @lji.org @settelab.bsky.social @columbiauniversity.bsky.social
www.nature.com/articles/s41... @nature.com @lji.org @settelab.bsky.social @columbiauniversity.bsky.social
October 1, 2025 at 5:02 PM
Amyotrophic lateral sclerosis is associated with autoimmune CD4 T cell recognition of C9orf72 & release of IL-5 and IL-10, w/ IL-10 correlating with longer survival
www.nature.com/articles/s41... @nature.com @lji.org @settelab.bsky.social @columbiauniversity.bsky.social
www.nature.com/articles/s41... @nature.com @lji.org @settelab.bsky.social @columbiauniversity.bsky.social
Reposted by BaumjohannLab
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
September 28, 2025 at 5:50 PM
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by BaumjohannLab
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo
Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
September 28, 2025 at 11:55 AM
We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
Reposted by BaumjohannLab
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....
onlinelibrary.wiley.com
September 26, 2025 at 7:19 AM
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Reposted by BaumjohannLab
Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
So happy to share that our review in #ImmunolRev is finally out! 😃 We discuss how the immune system builds specialized TLSs across organs and conditions. Huge thanks to @StephanGuillaume, @iannaconelab.bsky.social & @linterman.bsky.social for this collaboration!
dx.doi.org/10.1111/imr.70063
dx.doi.org/10.1111/imr.70063
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be...
dx.doi.org
September 25, 2025 at 7:53 PM
Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
Reposted by BaumjohannLab
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation www.science.org/doi/10.1126/...
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.
www.science.org
September 24, 2025 at 7:46 PM
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation www.science.org/doi/10.1126/...