Roderick
@shfo.bsky.social
South City. Formerly biogeochemistry/microbial bioinformatics; now software and bikes/urbanism/random plants.
I bought some sheet music off Nextdoor today and the past is such a distant place. What's a talking machine?
November 25, 2025 at 3:11 AM
I bought some sheet music off Nextdoor today and the past is such a distant place. What's a talking machine?
Reposted by Roderick
Every biologist knows the story of Fleming's chance discovery of penicillin. But is it true?
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
The Penicillin Myth
Competing theories seek to explain inconsistencies surrounding Alexander Fleming’s famed discovery.
press.asimov.com
November 24, 2025 at 5:00 PM
Every biologist knows the story of Fleming's chance discovery of penicillin. But is it true?
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
Reposted by Roderick
Tonight I’m taking a tour of SamTrans’ North Base with my fellow Citizens Advisory Committee members! We’ve seen maintenance, dispatch, and the new temporary hydrogen fuel station in the last shot.
November 20, 2025 at 4:16 AM
Tonight I’m taking a tour of SamTrans’ North Base with my fellow Citizens Advisory Committee members! We’ve seen maintenance, dispatch, and the new temporary hydrogen fuel station in the last shot.
Does anyone know how X is de-woking Grok now? The "white genocide" things was them editing the system prompt, but thry've improved since then. RAG? Some kind of post-training?
November 20, 2025 at 2:57 AM
Does anyone know how X is de-woking Grok now? The "white genocide" things was them editing the system prompt, but thry've improved since then. RAG? Some kind of post-training?
every time there's an issue at the data center, they light a big flare so all the traffic on the internet superhighway will avoid it. putting out all these fires is why data centers use so much more water nowadays.
you can't make me learn what "cloudflare" is. I shouldn't have to know these things. I have a sensitive artistic spirit
November 18, 2025 at 6:07 PM
every time there's an issue at the data center, they light a big flare so all the traffic on the internet superhighway will avoid it. putting out all these fires is why data centers use so much more water nowadays.
I grew popcorn this year and it's not very economical, but it is pretty.
November 16, 2025 at 11:24 PM
I grew popcorn this year and it's not very economical, but it is pretty.
Reposted by Roderick
Diving through the purple sulfur bacteria layer of Fayetteville Green Lake with our ROV last month. This is the most intense density of PSB that I've seen in many years!
November 8, 2025 at 6:30 PM
Diving through the purple sulfur bacteria layer of Fayetteville Green Lake with our ROV last month. This is the most intense density of PSB that I've seen in many years!
For South San Francisco people, there's a workshop at the library next Thurs (Oct 30) from 6:30-8:30 PM about redesigning ECR. A good opportunity to make it safe for bikes and walking: fp.mysocialpinpoint.com/el-camino-re...
SSF El Camino Real Mobility Plan
Reenvisioning the future of El Camino Real in South City.
fp.mysocialpinpoint.com
October 25, 2025 at 4:52 AM
For South San Francisco people, there's a workshop at the library next Thurs (Oct 30) from 6:30-8:30 PM about redesigning ECR. A good opportunity to make it safe for bikes and walking: fp.mysocialpinpoint.com/el-camino-re...
Reposted by Roderick
a good prank idea is to wait until someone falls asleep and then replace all their sandy loam with loamy sand
October 20, 2025 at 2:58 PM
a good prank idea is to wait until someone falls asleep and then replace all their sandy loam with loamy sand
I was playing with ollama and open 4b models (Qwen3 & Gemma) on my laptop and they're indistinguishable from the state-of-the-art models to me. I don't think that means data centers are obsolete (most people don't run their own compute), but there's going to be a limited need to keep building.
I continue to think that while "LLMs aren't actually that world-changing" is a risk people have at least started paying attention to, "good-enough LLMs are going to be cheap and ubiquitous and those $1B data centers are going to become a liability rather than a moat" is an equally serious problem
Andrej Karpathy unveils nanochat, a full-stack training and inference implementation of an LLM in a single, dependency-minimal codebase (Andrej Karpathy/@karpathy)
Main Link | Techmeme Permalink
Main Link | Techmeme Permalink
October 13, 2025 at 6:43 PM
I was playing with ollama and open 4b models (Qwen3 & Gemma) on my laptop and they're indistinguishable from the state-of-the-art models to me. I don't think that means data centers are obsolete (most people don't run their own compute), but there's going to be a limited need to keep building.
Reposted by Roderick
For the weekend crowd. I'm hiring a postdoc! If you're interested in algorithms, data structures and high-dimensional inference, and if you want to invent new methods for genomics and implement them in high-performance, robust and easy-to-use software, do I have a lab for you; ours!
Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬
And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....
If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!
If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!
October 11, 2025 at 1:10 PM
For the weekend crowd. I'm hiring a postdoc! If you're interested in algorithms, data structures and high-dimensional inference, and if you want to invent new methods for genomics and implement them in high-performance, robust and easy-to-use software, do I have a lab for you; ours!
Reposted by Roderick
Are you the type of dev who just copies and pastes hex codes?
If so, I've written an article over at @piccalil.li just for you!
I take a look at some of the new CSS colour features that are most useful for those who don't really care about colours.
piccalil.li/blog/a-pragm...
If so, I've written an article over at @piccalil.li just for you!
I take a look at some of the new CSS colour features that are most useful for those who don't really care about colours.
piccalil.li/blog/a-pragm...
A pragmatic guide to modern CSS colours - part one
Whether you've got a firm grasp on modern CSS colour capabilities, or you're thinking 'I struggle to understand why I should use modern CSS colours at all', then the first part of this article series,...
piccalil.li
October 7, 2025 at 4:18 PM
Are you the type of dev who just copies and pastes hex codes?
If so, I've written an article over at @piccalil.li just for you!
I take a look at some of the new CSS colour features that are most useful for those who don't really care about colours.
piccalil.li/blog/a-pragm...
If so, I've written an article over at @piccalil.li just for you!
I take a look at some of the new CSS colour features that are most useful for those who don't really care about colours.
piccalil.li/blog/a-pragm...
Reposted by Roderick
Today and Sunday, shop at the SSF Education Foundation’s Book Fair and Read-a-thon to support its programs, 10 a.m. to 5 p.m. in the SSFLibrary’s 2nd floor Community Room. Several SSFUSD schools have wish lists!
October 4, 2025 at 6:22 PM
Today and Sunday, shop at the SSF Education Foundation’s Book Fair and Read-a-thon to support its programs, 10 a.m. to 5 p.m. in the SSFLibrary’s 2nd floor Community Room. Several SSFUSD schools have wish lists!
Reposted by Roderick
just one more lane bro. I promise bro just one more lane and it'll fix everything bro. bro, just one more lane. please just one more, one more lane and we can fix this whole problem bro, bro cmon just give me one more lane i promise bro, bro bro please ! just need one more lane
A plan by Brazil to privatize a highway that cuts through the Amazon rainforest to create an overland corridor to Peru and streamline commodity exports to China is alarming critics, who fear the country risks repeating its history by attracting illegal loggers and land grabbers. (via @mongabay.com)
Just One More Lane In Brazil's First Private Amazon Highway
An increasingly important route for transporting commodities from Brazil’s central-west region, BR-364 in Rondônia will be partially twinned and upgraded with passing lanes. Image courtesy of Marcio F...
www.thexylom.com
October 2, 2025 at 5:12 PM
just one more lane bro. I promise bro just one more lane and it'll fix everything bro. bro, just one more lane. please just one more, one more lane and we can fix this whole problem bro, bro cmon just give me one more lane i promise bro, bro bro please ! just need one more lane
Reposted by Roderick
Why go back to a Walmart in 2002 when you could go back 45 years and safely experience the eruption of Mount St. Helens on May 18, 1980?
Have some respect for yourself and hold your nostalgia to a higher standard.
Have some respect for yourself and hold your nostalgia to a higher standard.
This is doing numbers on social media right now and it's so depressing how people truly yearn for this shit and want to preserve that feeling indefinitely like a mausoleum of false memories.
September 29, 2025 at 3:57 PM
Why go back to a Walmart in 2002 when you could go back 45 years and safely experience the eruption of Mount St. Helens on May 18, 1980?
Have some respect for yourself and hold your nostalgia to a higher standard.
Have some respect for yourself and hold your nostalgia to a higher standard.
This is like three houses away from the SB79 upzoning that would let you build 5000 sq ft in five stories (code and Newsom willing).
this is the housing market but at least we're investigating what happened to amelia earhart
September 27, 2025 at 8:06 PM
This is like three houses away from the SB79 upzoning that would let you build 5000 sq ft in five stories (code and Newsom willing).
Man bursts into tears. Says "but doctor, my neighborhood doesn't have the density to support amenities like bars."
The cure to the male loneliness epidemic is YIMBY happy hours
September 25, 2025 at 11:09 PM
Man bursts into tears. Says "but doctor, my neighborhood doesn't have the density to support amenities like bars."
Reposted by Roderick
Former SSF Mayor Pedro Gonzalez died last week at the age of 92. Pedro advocated for South City as a whole and Old Town in particular, supported my school board campaigns, and was a genuinely sweet man. My love to his wife Eldie and family. www.gardenchapel885.com/obituaries/P...
Obituary information for Pedro Gonzalez
View Pedro Gonzalez's obituary, contribute to their memorial, see their funeral service details, and more.
www.gardenchapel885.com
September 18, 2025 at 4:35 PM
Former SSF Mayor Pedro Gonzalez died last week at the age of 92. Pedro advocated for South City as a whole and Old Town in particular, supported my school board campaigns, and was a genuinely sweet man. My love to his wife Eldie and family. www.gardenchapel885.com/obituaries/P...
Reposted by Roderick
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
Reposted by Roderick
Aw man, no, RIP Maru the cat. That little man brought so much joy to my life for years and years. ❤️ en.m.wikipedia.org/wiki/Maru_(c...
Maru (cat) - Wikipedia
en.m.wikipedia.org
September 6, 2025 at 3:06 PM
Aw man, no, RIP Maru the cat. That little man brought so much joy to my life for years and years. ❤️ en.m.wikipedia.org/wiki/Maru_(c...
Reposted by Roderick
Haven’t seen any mentions about it yet, but the Hetch Hetchy water pipeline and powerlines run under and across Don Pedro right between the active 6-2 and 6-5 fires. The Foothills Tunnel has a siphon on the west bank and delivers 165 M/gal/day to SF Bay Area (85% of water supply for 2.8M people).
September 3, 2025 at 7:41 PM
Haven’t seen any mentions about it yet, but the Hetch Hetchy water pipeline and powerlines run under and across Don Pedro right between the active 6-2 and 6-5 fires. The Foothills Tunnel has a siphon on the west bank and delivers 165 M/gal/day to SF Bay Area (85% of water supply for 2.8M people).
Reposted by Roderick
Reposted by Roderick
Fuente: los pijos de BS.
August 11, 2025 at 7:48 AM
Fuente: los pijos de BS.
Every week someone here posts "the government's going to shut down the internet; get a ham radio" and I hate to break it to you all, but you have to broadcast your address-linked government ID every 10 minutes in amateur radio.
August 7, 2025 at 2:40 AM
Every week someone here posts "the government's going to shut down the internet; get a ham radio" and I hate to break it to you all, but you have to broadcast your address-linked government ID every 10 minutes in amateur radio.
