David Hofer
@hofer.bsky.social
I work on software for tracking genome sequences, edits and variants. Cat dad. Boston, MA
New-ish Genhub post: Viewing sequence graphs in the terminal, using the e coli “repo” we set up in an earlier post: www.genhub.bio/blog/2025/11...
GenHub
www.genhub.bio
November 14, 2025 at 4:29 PM
New-ish Genhub post: Viewing sequence graphs in the terminal, using the e coli “repo” we set up in an earlier post: www.genhub.bio/blog/2025/11...
Reposted by David Hofer
Reposted by David Hofer
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 8, 2025 at 9:58 PM
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Some news: Last April, I left Ginkgo Bioworks after 8+ years as a software engineer there. Since then, I’ve been working on starting a new company called GenHub with a couple other ex-Ginkgo people, Bob Van Hove and Chris Mitchell. (1/5)
November 5, 2025 at 11:10 PM
Some news: Last April, I left Ginkgo Bioworks after 8+ years as a software engineer there. Since then, I’ve been working on starting a new company called GenHub with a couple other ex-Ginkgo people, Bob Van Hove and Chris Mitchell. (1/5)
Reposted by David Hofer
The future of dental flossing may include vaccine delivery!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 17, 2025 at 2:00 PM
The future of dental flossing may include vaccine delivery!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Toledo continues his love/hate relationship with the paper that makes scary crackling noises but feels so comfortable
October 8, 2025 at 2:59 PM
Toledo continues his love/hate relationship with the paper that makes scary crackling noises but feels so comfortable
Reposted by David Hofer
If you're good at admin, do admin for a wind developer. If you're bad at admin, do it for a chain of petrol stations.
September 29, 2025 at 1:19 PM
If you're good at admin, do admin for a wind developer. If you're bad at admin, do it for a chain of petrol stations.
Reposted by David Hofer
Feeling alright about that 6th-inning medley of "Love Will Keep Us Together" into "Love Will Tear Us Apart."
September 28, 2025 at 8:42 PM
Feeling alright about that 6th-inning medley of "Love Will Keep Us Together" into "Love Will Tear Us Apart."
Reposted by David Hofer
CHOTINER: And you didn’t know this person - what did you call him again?
CELEBRIMBOR GREATEST OF THE ELVEN SMITHS: Right, his name was Annatar but
CHOTINER: And you taught him to create a ring harnessing all his malice and cruelty?
CELEBRIMBOR: Well I mean I was deceived
CHOTINER: So you’ve said
CELEBRIMBOR GREATEST OF THE ELVEN SMITHS: Right, his name was Annatar but
CHOTINER: And you taught him to create a ring harnessing all his malice and cruelty?
CELEBRIMBOR: Well I mean I was deceived
CHOTINER: So you’ve said
September 24, 2025 at 11:02 PM
CHOTINER: And you didn’t know this person - what did you call him again?
CELEBRIMBOR GREATEST OF THE ELVEN SMITHS: Right, his name was Annatar but
CHOTINER: And you taught him to create a ring harnessing all his malice and cruelty?
CELEBRIMBOR: Well I mean I was deceived
CHOTINER: So you’ve said
CELEBRIMBOR GREATEST OF THE ELVEN SMITHS: Right, his name was Annatar but
CHOTINER: And you taught him to create a ring harnessing all his malice and cruelty?
CELEBRIMBOR: Well I mean I was deceived
CHOTINER: So you’ve said
Reposted by David Hofer
Critics of renewables often point to land use as a reason not to invest in wind & solar. Land use IS a real issue for all energy assets incl renewables (unless on-site).
But what critics conveniently forget is the huge land impact of fossil fuels. Aerial view of fracking sites in Wickett, Texas. 👇
But what critics conveniently forget is the huge land impact of fossil fuels. Aerial view of fracking sites in Wickett, Texas. 👇
September 23, 2025 at 12:25 PM
Critics of renewables often point to land use as a reason not to invest in wind & solar. Land use IS a real issue for all energy assets incl renewables (unless on-site).
But what critics conveniently forget is the huge land impact of fossil fuels. Aerial view of fracking sites in Wickett, Texas. 👇
But what critics conveniently forget is the huge land impact of fossil fuels. Aerial view of fracking sites in Wickett, Texas. 👇
Reposted by David Hofer
incredible photo on wikimedia commons that isn't currently used in any articles
September 17, 2025 at 3:13 PM
incredible photo on wikimedia commons that isn't currently used in any articles
Reposted by David Hofer
Reposted by David Hofer
What do real landowners and local officials think about wind and solar projects? We asked them in our last report that focused on Texas:
txrenewables.net
See below for what they said.
txrenewables.net
See below for what they said.
August 22, 2025 at 5:35 PM
What do real landowners and local officials think about wind and solar projects? We asked them in our last report that focused on Texas:
txrenewables.net
See below for what they said.
txrenewables.net
See below for what they said.
Reposted by David Hofer
It seems to be the summer of woodchucks. I’ve never seen so many around.
August 6, 2025 at 9:50 PM
It seems to be the summer of woodchucks. I’ve never seen so many around.
If anyone is on the fence about getting dental surgery for your cat (if they’re in pain and need it), you have to consider that getting to see them high on anesthetic for a couple hours afterwards is worth at least a few hundred dollars of amusement
August 1, 2025 at 1:05 AM
If anyone is on the fence about getting dental surgery for your cat (if they’re in pain and need it), you have to consider that getting to see them high on anesthetic for a couple hours afterwards is worth at least a few hundred dollars of amusement
Reposted by David Hofer
Everything about this is glorious.
July 30, 2025 at 6:24 PM
Everything about this is glorious.
Reposted by David Hofer
This is how your email finds me.
April 14, 2025 at 7:39 AM
This is how your email finds me.
Saw this over on the other site, man TDF fans are the best
July 24, 2025 at 8:16 PM
Saw this over on the other site, man TDF fans are the best
Reposted by David Hofer
People: World Cup can't happen now FIFA will pull out
football fans: FIFA will just do corruption
People: who even understands how to be corrupt well enough to navigate this situation?
FIFA:
www.insideworldfootball.com/2025/07/08/f...
football fans: FIFA will just do corruption
People: who even understands how to be corrupt well enough to navigate this situation?
FIFA:
www.insideworldfootball.com/2025/07/08/f...
FIFA opens office at Trump Tower, New York - Inside World Football
July 8 – FIFA has opened an office at Trump Tower in New York City, deepening its already close ties with the much-criticised US administration.
US President Donald Trump and FIFA supremo Gianni Infa...
www.insideworldfootball.com
July 8, 2025 at 11:49 AM
People: World Cup can't happen now FIFA will pull out
football fans: FIFA will just do corruption
People: who even understands how to be corrupt well enough to navigate this situation?
FIFA:
www.insideworldfootball.com/2025/07/08/f...
football fans: FIFA will just do corruption
People: who even understands how to be corrupt well enough to navigate this situation?
FIFA:
www.insideworldfootball.com/2025/07/08/f...
Kudos to the Tesla I saw earlier today with a license plate of LOLWATT
July 7, 2025 at 12:42 AM
Kudos to the Tesla I saw earlier today with a license plate of LOLWATT
Whenever I’m standing around with nothing better to do, like watching fireworks, I imagine talking to someone who lived here 200 or 300 years ago. That big skyscraper to the right? It’s part way between the South End and the Charles. Yeah, they filled in all the swamp there
July 5, 2025 at 2:40 AM
Whenever I’m standing around with nothing better to do, like watching fireworks, I imagine talking to someone who lived here 200 or 300 years ago. That big skyscraper to the right? It’s part way between the South End and the Charles. Yeah, they filled in all the swamp there
Reposted by David Hofer
This doesn’t happen often, but today I was preoccupied thinking about how I didn’t make it through grad school. Toledo was there to help 🙏🏻
June 28, 2025 at 11:32 PM
This doesn’t happen often, but today I was preoccupied thinking about how I didn’t make it through grad school. Toledo was there to help 🙏🏻