David Hofer
@hofer.bsky.social
I work on software for tracking genome sequences, edits and variants. Cat dad. Boston, MA
Toledo continues his love/hate relationship with the paper that makes scary crackling noises but feels so comfortable
October 8, 2025 at 2:59 PM
Toledo continues his love/hate relationship with the paper that makes scary crackling noises but feels so comfortable
He looks a lot like my Hamburg!
October 7, 2025 at 10:09 PM
He looks a lot like my Hamburg!
It seems to be the summer of woodchucks. I’ve never seen so many around.
August 6, 2025 at 9:50 PM
It seems to be the summer of woodchucks. I’ve never seen so many around.
Saw this over on the other site, man TDF fans are the best
July 24, 2025 at 8:16 PM
Saw this over on the other site, man TDF fans are the best
Whenever I’m standing around with nothing better to do, like watching fireworks, I imagine talking to someone who lived here 200 or 300 years ago. That big skyscraper to the right? It’s part way between the South End and the Charles. Yeah, they filled in all the swamp there
July 5, 2025 at 2:40 AM
Whenever I’m standing around with nothing better to do, like watching fireworks, I imagine talking to someone who lived here 200 or 300 years ago. That big skyscraper to the right? It’s part way between the South End and the Charles. Yeah, they filled in all the swamp there
This doesn’t happen often, but today I was preoccupied thinking about how I didn’t make it through grad school. Toledo was there to help 🙏🏻
June 28, 2025 at 11:32 PM
This doesn’t happen often, but today I was preoccupied thinking about how I didn’t make it through grad school. Toledo was there to help 🙏🏻
One of my cats, when confronted with near-record heat, is like Ford Prefect when confronted with Vogon poetry. He hates it but is resigned to it.
The other is like Arthur Dent. He lolls around, then decides he actually kind of likes it
The other is like Arthur Dent. He lolls around, then decides he actually kind of likes it
June 24, 2025 at 10:39 PM
One of my cats, when confronted with near-record heat, is like Ford Prefect when confronted with Vogon poetry. He hates it but is resigned to it.
The other is like Arthur Dent. He lolls around, then decides he actually kind of likes it
The other is like Arthur Dent. He lolls around, then decides he actually kind of likes it
Yeet me into the future where the New England grid isn’t running on 12% oil and 48% natural gas on a hot day. www.iso-ne.com
June 24, 2025 at 10:31 PM
Yeet me into the future where the New England grid isn’t running on 12% oil and 48% natural gas on a hot day. www.iso-ne.com
Cat reactions to a heat wave
June 23, 2025 at 1:43 PM
Cat reactions to a heat wave
Toledo the tuxedo cat and Hamburg (the tabby who claims my chair) say hi
June 15, 2025 at 9:12 PM
Toledo the tuxedo cat and Hamburg (the tabby who claims my chair) say hi
32 minutes before their dinner time
May 11, 2025 at 8:01 PM
32 minutes before their dinner time
I want to get dinner but I can’t get dinner
February 11, 2025 at 11:30 PM
I want to get dinner but I can’t get dinner
Good pillows make good neighbors
February 1, 2025 at 4:59 PM
Good pillows make good neighbors
The cold weather finally prompted me to set up a bird feeder to help them get through to spring. I put it by my back window so I could watch them. My cats are also entertained
January 22, 2025 at 2:05 AM
The cold weather finally prompted me to set up a bird feeder to help them get through to spring. I put it by my back window so I could watch them. My cats are also entertained
I can’t believe it, their paws are touching 😻
December 16, 2024 at 4:30 PM
I can’t believe it, their paws are touching 😻
As someone working in synthetic biology, I appreciate that although Frieren the mage knows lots of spells for offensive and defensive magic, and who knows what else, her favorite spell is one that creates a field of flowers
November 20, 2024 at 12:05 AM
As someone working in synthetic biology, I appreciate that although Frieren the mage knows lots of spells for offensive and defensive magic, and who knows what else, her favorite spell is one that creates a field of flowers
Well, this is a novel position on his part in “help, I can’t move my leg”
November 1, 2024 at 11:02 PM
Well, this is a novel position on his part in “help, I can’t move my leg”
It’s fall again, I’m wearing long pants again, Hamburg is asleep against my leg on the footstool again. I like this turning of the wheel
September 21, 2024 at 9:10 PM
It’s fall again, I’m wearing long pants again, Hamburg is asleep against my leg on the footstool again. I like this turning of the wheel
All Toledo needs is a cardboard box and a sunbeam.
September 7, 2024 at 2:26 PM
All Toledo needs is a cardboard box and a sunbeam.
I hiked Hurricane Mountain in the Adirondacks yesterday.
September 2, 2024 at 8:39 PM
I hiked Hurricane Mountain in the Adirondacks yesterday.
I decided to follow the vet’s rec and bring in Toledo for dental surgery. He’s been wobbling around in the kitchen as the anaesthetic wears off. They warned me to keep Hamburg away today as Toledo’s scent might make him unrecognizable, causing Hamburg to attack. Hamburg’s actual reaction:
June 25, 2024 at 11:57 PM
I decided to follow the vet’s rec and bring in Toledo for dental surgery. He’s been wobbling around in the kitchen as the anaesthetic wears off. They warned me to keep Hamburg away today as Toledo’s scent might make him unrecognizable, causing Hamburg to attack. Hamburg’s actual reaction:
Hamburg has melted over my leg
June 6, 2024 at 11:39 PM
Hamburg has melted over my leg